Mild exercise decreases plasma endogenous digitalislike substance in hypertensive individuals.

Abstract

Changes in a plasma endogenous digitalislike substance were investigated in relation to the antihypertensive mechanism of mild exercise. Fifteen women with mild essential hypertension and seven normotensive female volunteers were divided into exercised hypertensive (n = 10), nonexercised hypertensive (n = 5), and nonexercised normotensive (n = 7) groups. A 4-week general clinical observation period preceded the study period of 10 weeks. The exercised hypertensive individuals were treated with a lactate threshold exercise that corresponded to approximately 50% of the maximum oxygen consumption three times a week, whereas the nonexercised groups were observed at the outpatient clinic as control groups. In the exercised group, systolic blood pressure fell by 7 mm Hg (p = 0.05), diastolic by 6 mm Hg (p less than 0.01), and mean blood pressure by 7 mm Hg (p less than 0.01) after 10 weeks. The reduction in the plasma endogenous digitalislike substance was significant after 7 (-1.02 ng/ml, p less than 0.05) and 10 (-1.04 ng/ml, p less than 0.05) weeks in this group. It positively correlated with the reduction in diastolic (r = 0.70, p less than 0.05) or mean (r = 0.66, p less than 0.05) blood pressure and with changes in plasma norepinephrine (r = 0.76, p less than 0.05). The mean corpuscular volume of erythrocytes decreased (-1.7 fl, p less than 0.01) after 10 weeks of exercise, and the plasma volume index tended to decrease (-108 ml/m2, p = 0.28). In the control groups, significant changes in blood pressure and plasma endogenous digitalislike substance were not observed.(ABSTRACT TRUNCATED AT 250 WORDS)

Influência do exercício aeróbio na renina de portadores de hipertensão arterial com sobrepeso

“…Plasma renin activity did not change in the exercised group, with a variation of -0.37 (ng/ml/hr). Blood volume did not decrease, perhaps because of the short duration of the exercise protocol (10 weeks) or due to other mechanisms, since longer periods of training resulted in a decrease in blood volume 22 …”

Ouabain-Like Compound Changes Rapidly on Physical Exercise in Humans and Dogs

“…Previous studies showed ambiguous results. An increase 9 as well as a decrease of plasma concentrations of ouabain-like compounds (OLCs) 10,11 have been reported. Here, we investigated the effect of physical exercise on the endogenous ouabain plasma concentration in several experimental settings as well as the influence of ␤-blockade and angiotensin-converting enzyme (ACE) inhibition.…”

Mild physical exercise may activate the adenosine-dopamine system: A new natriuretic mechanism

“…Exercise, therefore, seems to induce the adenosine-dopamine system and cause natriuresis. In addition, we have also found an increase in plasma taurine [12], prostaglandin E [4], and urine kallikrein activity [15], and a decrease in mean corpuscular volume [5,14], all of which must also help natriuresis.…”

“…One might suspect that this is due to sweating during exercise, but this is not likely in our study because 1) exercise was done moderately, at lactic threshold intensity or approximately 50% maximum oxygen uptake (VO 2 max), which is practically nonsweating intensity; and 2) in case any sweating occurred during and right after exercise, all the parameters including hemodynamic and biochemical changes were examined 48 to 72 hours after the last performance of exercise to determine the chronic effect in order to avoid any acute effect of exercise [4,5]. We consequently looked for any body fluid regulators that are responsible for the natriuresis, such as aldosterone, prostaglandin E, vasopressin, taurine [12], atrial natriuretic peptide (ANP) [13], endogenous ouabain-like substance (EOLS) [14], kallikreinkinin system [15], dopamine [13], and so forth.…”