Mild Gestational Hyperglycemia and the Metabolic Syndrome in Later Life

Abstract

Women who failed the OGCT, but not the OGTT, showed a subsequent worse metabolic pattern than pNGT subjects, independently of confounding factors. In the presence of obesity, the prevalence of the metabolic syndrome was similar to that of obese pGDM women, and almost twofold higher than in obese pNGT controls.

Glucose Intolerance in Pregnancy and Postpartum Risk of Metabolic Syndrome in Young Women

“…Previous studies have reported high rates of the metabolic syndrome in women with a history of GDM (11,12,(25)(26)(27)(28). Indeed, at median 9.8 yr postpartum, the prevalence of metabolic syndrome (by World Health Organization criteria) was 38.4% in Danish women with previous GDM, compared with 13.4% in their peers (11).…”

Gestational Diabetes and the Metabolic Syndrome

“…This risk is 10 times higher in women with concomitant pre-pregnancy obesity (Bo et al, 2004a). Thus, even mild gestational hyperglycemia predicts metabolic syndrome (Bo et al, 2004b), and metabolic syndrome is increasingly more likely to develop over time following the index pregnancy (Bo et al, 2006). These studies highlight the chronic nature of the metabolic dysfunction associated with GDM.…”

Cardiometabolic Risk, Knowledge, Risk Perception, and Self‐Efficacy among American Indian Women with Previous Gestational Diabetes

“…Gestational diabetes mellitus (GDM), a form of glucose intolerance diagnosed during pregnancy, affects more than 200,000 women each year in the United States or about 7% of all pregnant women (American Diabetes Association [ADA], ). Gestational diabetes mellitus is considered a unique metabolic syndrome risk factor in women (Bentley‐Lewis, Koruda, & Seely, ; Bo et al, ; Retnakaran et al, ; Vohr & Boney, ), indicating increased risk for type 2 diabetes and CVD (Alberti et al, ) and the need for early risk factor surveillance in this population. In general, women with previous GDM have a 20% to 50% chance of developing type 2 diabetes in the next 5 to 10 years (ADA), whereas cumulative incidence has been reported as high as 70% among American Indian women with previous GDM (Kim, Newton, & Knopp, ).…”