Mild heart failure is a mortality marker after a non-ST-segment acute myocardial infarction

Núñez‐Gil, Iván J.; Garcı́a-Rubira, Juan C.; Luaces, María; Vivas, David; Agustín, José; González-Ferrer, Juan José; Bordes, Sara; Macaya, Carlos; Fernández‐Ortíz, Antonio

doi:10.1016/j.ejim.2010.06.003

Cited by 17 publications

(11 citation statements)

References 30 publications

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“…17 Data from the FAST-MI registry in France showed that 32% of 3059 AMI patients enrolled in the study during 2005 presented or developed HF during the AMI hospitalization. 7 Our results are in line with recent registerbased studies including similar patients to ours 8,18 with regard to development of in-hospital HF.…”

Section: Discussionsupporting

confidence: 91%

Heart Failure Complicating Acute Myocardial Infarction; Burden and Timing of Occurrence: A Nation‐wide Analysis Including 86 771 Patients From the Cardiovascular Disease in Norway (CVDNOR) Project

Sulo

Igland

Vollset

et al. 2016

JAHA

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BackgroundCoronary heart disease (CHD) represents often the underlying conditions for the development of heart failure (HF). We aimed at exploring the burden and timing of HF complicating an acute myocardial infarction (AMI), using the total population of AMI patients hospitalized during 2001–2009 in Norway.Methods and ResultsA total of 86 771 patients with a first AMI during 2001–2009 and without previous HF were identified in the “Cardiovascular Disease in Norway” project and followed until HF development, death, or December 31, 2009. In 16 219 patients (18.7%), HF was present on admission or developed during hospitalization for the incident AMI. HF occurrence varied according to age (8.9%, 15.2%, and 25.6% among men and 10.2%, 16.8%, and 27.1% among women ages 25–54, 55–74, and 75–85 years). Among 63 853 patients discharged alive without HF, 8058 (12.6%) were hospitalized with or died because of HF during a median follow‐up time of 3.2 years. HF incidence rates (IRs) per 1000 person‐years during follow‐up were 31 (95% CI, 30–32) for men and 46 (95% CI, 44–47) for women (P<0.01). IRs of HF were highest during the first 6 months of follow‐up, after which they leveled off and remained stable until the end of follow‐up.ConclusionsIn this nation‐wide cohort study, we observed that HF remains a frequent complication of the first AMI; both during the acute phase and shortly after the discharge from the hospital.

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Section: Discussionsupporting

confidence: 91%

Heart Failure Complicating Acute Myocardial Infarction; Burden and Timing of Occurrence: A Nation‐wide Analysis Including 86 771 Patients From the Cardiovascular Disease in Norway (CVDNOR) Project

Sulo

Igland

Vollset

et al. 2016

JAHA

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“…Although there has been a significant decrease in the incidence rates of HF following AMI (almost threefold in , where appropriate; AMI-AHF(+) -a group of patients admitted to the hospital due to AMI with AHF; AMI-AHF(-) -a group of patients admitted to the hospital due to AMI without AHF; AlAT -alanine aminotransferase; AspAT -aspartate aminotransferase; BP -blood pressure; CRT -cardiac resynchronisation therapy; eGFR -estimated glomerular filtration rate; GGTP -gamma-glutamyl transpeptidase; hs-TnI -high-sensitivity troponin I; ICD -implantable cardioverter defibrillator; IVSD -interventricular septal thickness at diastole; LVEDD -left ventricular end diastolic diameter; LVEF -left ventricular ejection fraction; NT-proBNP -N-terminal prohormone of B-type natriuretic peptide; PLT -platelets; RVEDD -right ventricular end diastolic diameter; WBC -white blood cells the last four decades) due to significant achievement in treatment of AMI and HF, the prognosis of patients with AMI complicated by HF still remains extremely fatal [1][2][3][4][5]. McManus et al [2] reported a decline in the prevalence of 30-day deaths in patients with AHF during index hospitalisation due to AMI between 1975 (29%) and 2003 (16%).…”

Section: Discussionmentioning

confidence: 99%

“…The natural history of patients with coexisting acute myocardial infarction (AMI) and acute heart failure (AHF) is extremely fatal [1][2][3][4][5]. Although the rates of heart failure (HF) occurring in the later phase of AMI have been reduced in recent decades due to the introduction of modern pharmacotherapy and primary percutaneous coronary intervention [2,3,6], it still remains unclear regarding AHF presenting together with the acute phase of AMI in the emergency department (ED) [2,3,7].…”

Section: Introductionmentioning

confidence: 99%

Acute heart failure in patients admitted to the emergency department with acute myocardial infarction

et al. 2017

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A b s t r a c tBackground: Acute heart failure (AHF), occurring as a complication of ongoing acute myocardial infarction (AMI), is a common predictor of worse clinical outcome. Much less is known about the unique subpopulation of patients who present these two life-threatening conditions in the emergency department (ED). Aim:The aim of the study was to establish the prevalence of coexistence of AHF with AMI in the ED, to identify clinical factors associated with the higher prevalence of AHF at very early onset of AMI, and to assess the prognostic impact of the presence of AHF with AMI. Methods:A prospective study of 289 consecutive patients (mean age: 68 ± 11 years, 61% men) admitted to our institution (via the ED) with the diagnosis of AMI between May and October 2012 and followed-up for 2.5 years.Results: Acute heart failure was diagnosed in 13% of patients in the ED. In multivariable analysis, female sex, chronic obstructive pulmonary disease, and chronic kidney disease significantly increased the risk of developing AHF together with AMI (all p < 0.05). Patients with AHF were hospitalised for longer (9.2 ± 6.1 vs. 6.3 ± 4.5 days, p < 0.001), had higher in-hospital cardiovascular mortality (8% vs. 0%, p < 0.001), and all-cause (34% vs. 15%, p = 0.004) and cardiovascular mortality (26% vs. 9%, p = 0.002) during long-term follow-up. Conclusions:Despite good logistic-and evidence-based treatment, AHF is present in one in eight patients with AMI at the time of admission to the ED. Particularly poor outcomes characterise critically ill patients; therefore, great effort should be undertaken to improve their care.

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“…10–13 The presence of HF substantially increases the risk of death among patients hospitalised with an AMI. 14–16…”

Section: Introductionmentioning

confidence: 99%

Higher education is associated with reduced risk of heart failure among patients with acute myocardial infarction: A nationwide analysis using data from the CVDNOR project

Sulo

Nygård

Vollset

et al. 2016

Eur J Prev Cardiolog

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Mild heart failure is a mortality marker after a non-ST-segment acute myocardial infarction

Cited by 17 publications

References 30 publications

Heart Failure Complicating Acute Myocardial Infarction; Burden and Timing of Occurrence: A Nation‐wide Analysis Including 86 771 Patients From the Cardiovascular Disease in Norway (CVDNOR) Project

Heart Failure Complicating Acute Myocardial Infarction; Burden and Timing of Occurrence: A Nation‐wide Analysis Including 86 771 Patients From the Cardiovascular Disease in Norway (CVDNOR) Project

Acute heart failure in patients admitted to the emergency department with acute myocardial infarction

Higher education is associated with reduced risk of heart failure among patients with acute myocardial infarction: A nationwide analysis using data from the CVDNOR project

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