Mild hyperthermia-mediated osteogenesis and angiogenesis play a critical role in magnetothermal composite-induced bone regeneration

Wang, Lingtian; Hu, Ping; Jiang, Han; Zhao, Jinhui; Tang, Jin; Jiang, Dajun; Wang, Jiaxing; Shi, Jianlin; Jia, Weitao

doi:10.1016/j.nantod.2022.101401

Cited by 57 publications

(49 citation statements)

References 46 publications

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“…MC3T3‐E1, an osteoblast precursor cell line, was employed to verify the cell attachment and proliferation on PEEK before and after functional surface modification. [ 32 ] From the SEM images ( Figure a), cells show superior outspread morphology and bond tightly to all samples even under the sustained hyperglycemic setting. Owing to the 3D microstructure of bioHJs and their excellent hydrophilicity, cells on SP‐Cu/G@GO x exhibit more extended filopodia.…”

Section: Resultsmentioning

confidence: 99%

Bioheterojunction‐Engineered Polyetheretherketone Implants With Diabetic Infectious Micromilieu Twin‐Engine Powered Disinfection for Boosted Osteogenicity

Shu

Dai

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Bioheterojunction‐Engineered Polyetheretherketone Implants With Diabetic Infectious Micromilieu Twin‐Engine Powered Disinfection for Boosted Osteogenicity

Shu

Dai

et al. 2022

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“…This therapy was based on the fact that scaffolds involving MnFe 2 O 4 nanoparticles could generate mild magnetic hyperthermia and promote osteogenesis by PI3K/Akt pathway. 131 The effect of drug loading on osteoblasts can further help bone tissue repair and regeneration. Fe-HA nanoparticles are typical iron-doped particles that were fabricated by incorporating Fe 2+ /Fe 3+ ions into HAp particles.…”

Section: Effects Of Iron Ions On Bone Tissuementioning

confidence: 99%

“…Wang et al discovered magnetic iron oxide nanoparticle-induced mild magnetothermal therapy, which is considered to be a promising treatment for regeneration of bone defect. This therapy was based on the fact that scaffolds involving MnFe 2 O 4 nanoparticles could generate mild magnetic hyperthermia and promote osteogenesis by PI3K/Akt pathway …”

Section: Effects Of Iron Ions On Bone Tissue Engineeringmentioning

confidence: 99%

Effects of Zinc, Magnesium, and Iron Ions on Bone Tissue Engineering

Chen

Zhang

Wang

et al. 2022

ACS Biomater. Sci. Eng.

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Large-sized bone defects are a great challenge in clinics and considerably impair the quality of patients’ daily life. Tissue engineering strategies using cells, scaffolds, and bioactive molecules to regulate the microenvironment in bone regeneration is a promising approach. Zinc, magnesium, and iron ions are natural elements in bone tissue and participate in many physiological processes of bone metabolism and therefore have great potential for bone tissue engineering and regeneration. In this review, we performed a systematic analysis on the effects of zinc, magnesium, and iron ions in bone tissue engineering. We focus on the role of these ions in properties of scaffolds (mechanical strength, degradation, osteogenesis, antibacterial properties, etc.). We hope that our summary of the current research achievements and our notifications of potential strategies to improve the effects of zinc, magnesium, and iron ions in scaffolds for bone repair and regeneration will find new inspiration and breakthroughs to inspire future research.

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“…Exchange‐coupled CoFe 2 O 4 @MnFe 2 O 4 core@shell NPs generated a slight temperature difference of about 2–4 °C under AMF (1.35 kA m −1 , frequency: not described). [ 158 ] Heat difference served as heat stress to promote heat shock protein 90 (HSP 90)‐activated extracellular regulated protein kinase pathway. Thermal stimuli activated biomineralization in osteoblast and angiogenesis in the bone defect region, and released transition metal ions also contributed to bone regeneration.…”

Section: Remote Magnetic Heating For Thermal Stimulationmentioning

confidence: 99%

Multifunctional Magnetic Nanoparticles for Dynamic Imaging and Therapy

Hong

Choi

et al. 2022

Advanced NanoBiomed Research

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Dynamic therapy is a key research area for noninvasive clinical therapeutics. Up to now, light, electricity, ultrasound, and magnetic field have been investigated for the potential remote cellular regulation tools. Opening ion channels, activating cell death, and manipulating individual receptors that can control various cellular signal pathways have been suggested using external energy forms that can be dynamically applied in situ, which advance from the static control strategies. [1][2][3][4] For instance, optogenetics using light [5,6] have greatly advanced cellular modulation over the past decades, especially for neuromodulation. [7] Other energy sources have also been demonstrated with promising potential for regulating cellular metabolism and death. However, controlling the penetration and localization of energy sources (e.g., light and electricity) in tissues and cells have been challenging for in vivo applications. On the other hand, a magnetic field can safely penetrate deep tissues, which is particularly relevant for clinical applications. Consequently, utilizing the magnetic field to manipulate the MNPs is emerging as an effective approach to dynamically regulate cellular activity. [8] Recent advancements of multifunctional MNPs, spintronics, and magnetogenetics have enabled precise modulation of magnetic field gradients and pulses to remotely control the movement, heat generation, and reactive oxygen species (ROS) generation of the MNPs (Figure 1).Engineering multifunctional magnetic particles is the key requirement to achieve desired biomedical applications. [9][10][11] In the past 20 years, MNPs have received increasing attention

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Mild hyperthermia-mediated osteogenesis and angiogenesis play a critical role in magnetothermal composite-induced bone regeneration

Cited by 57 publications

References 46 publications

Bioheterojunction‐Engineered Polyetheretherketone Implants With Diabetic Infectious Micromilieu Twin‐Engine Powered Disinfection for Boosted Osteogenicity

Bioheterojunction‐Engineered Polyetheretherketone Implants With Diabetic Infectious Micromilieu Twin‐Engine Powered Disinfection for Boosted Osteogenicity

Effects of Zinc, Magnesium, and Iron Ions on Bone Tissue Engineering

Multifunctional Magnetic Nanoparticles for Dynamic Imaging and Therapy

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