Mild hypobaric hypoxia preconditioning up-regulates expression of transcription factors c-Fos and NGFI-A in rat neocortex and hippocampus

Antidepressant Effect of Hypoxic Preconditioning Is Associated with Modification of Expression of Transcription Factor c-Fos in Rat Brain in Response to Unavoidable Stress

“…Enhanced expression of c-Fos in the early period can also contribute to the antidepressant effects of HP via stimulation of the transcription of many pro-adaptive target genes. This is consistent with published data that up-regulation of c-Fos plays an important role in the development of neuronal tolerance against severe hypoxia and ischemia [8,10]. The present fi ndings extend our understanding of the functional roles of c-Fos suggesting its involvement in the mechanisms underlying induction of depressive disorders and their correction.…”

Comparative transcriptomic and proteomic analyses provide insights into the key genes involved in high-altitude adaptation in the Tibetan pig

“…The functional effects of the up-regulation of CD44 and its variant isoforms under hypoxic conditions, particularly in the context of hyaluronan levels, should be considered, as cell signaling events that promote anchorage-independent tumor cell growth, survival, migration, and metastasis occur through the binding of hyaluronan with CD44 40, 42, 43 . In addition, expression of FOS (also known as c-FOS ), which was previously reported to be associated with the hypoxia response 44, 45 , was 17.3-fold higher in TL than in YL. Together, these data suggest that characterization of DEGs that differ between the two pig breeds could provide clues to understanding the distinct hypoxic adaptations of these animals.…”

Hypoxic preconditioning modifies the activity of prond antioxidant systems in rat hippocampus

“…Ранее на используемой в настоящем исследовании экспериментальной модели установлено, что запускаемые гипоксическим прекондиционированием механизмы нейропротекции включают индукцию ранних генов и их продуктов -транскрипционных факторов [10,11,28], антиапоптозных факторов семейства генов bcl-2 [26,27], цитозольных и митохондриальных антиоксидантов [23][24][25]. Кроме того, гипоксическое прекондиционирование существенно повышает стрессореактивность гипофизарно-адренокортикальной системы, одновременно нормализуя её регуляцию по принципу отрицательной обратной связи, что, возможно, представляет один из ключевых механизмов адаптивного и антидепрессивного действия гипоксического прекондиционирования [8].…”