Mild hypothermia can enhance pial arteriolar vasodilation induced by isoflurane and sevoflurane in cats

Inoue, Satoki; Kawaguchi, Masahiko; Kurehara, Koukichi; Sakamoto, T.; Kishi, Katsuyoshi; Einaga, Toshi; Kitaguchi, Katsuyasu; Furuya, Hitoshi

doi:10.1097/00003246-200208000-00032

Cited by 7 publications

(7 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vasodilatory effects of hypothermia seem unexpected but have been observed in cerebral vessels as well. 37 In the present study, however, mHbO 2 increased independent of flow and vasodilatory effects could not be observed.…”

Section: Discussioncontrasting

confidence: 78%

Hypothermia improves oral and gastric mucosal oxygenation during hypoxic challenges

Vollmer

Weiss

Beck

et al. 2014

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 78%

Hypothermia improves oral and gastric mucosal oxygenation during hypoxic challenges

Vollmer

Weiss

Beck

et al. 2014

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

“…Saito et al [18] reported that hypothermia (23C) attenuated the vasorelaxation induced by K ATP channel openers, NIP-121, cromakalim and pinacidil, in guinea pig aorta without endothelium. In contrast, it was reported that MHT could enhance pial arteriolar vasodilation induced by cromakalim, isoflurane, and sevoflurane in cats [19,20]. On the other hand, Dojo et al [21] reported that MHT (33C) did not alter the vasodilation induced by a K ATP channel opener, levcromakalim, in rat aorta without endothelium.…”

Section: Discussionmentioning

confidence: 97%

Direct effect of mild hypothermia on the coronary vasodilation induced by an ATP-sensitive K channel opener, a nitric oxide donor and isoflurane in isolated rat hearts

Tosaka

Cho

et al. 2010

J Anesth

View full text Add to dashboard Cite

Purpose: Deliberate mild hypothermia (MHT) is applied for cerebroprotection after cardiopulmonary resuscitation and during cardiac surgery. MHT has been shown to alter both contractility and relaxation of blood vessels in the brain. However, the effects of MHT on drug-induced vasodilation are not fully understood. The aim of this study was to clarify the effects of MHT on the coronary vasodilation induced by cromakalim: an ATP-sensitive K channel opener, S-nitroso acetyl-penicillamine (SNAP): a nitric oxide donor, and isoflurane in isolated rat hearts.Methods: Male SD rat hearts were isolated and perfused with Krebs-Henseleit buffer.Coronary flow was measured with the coronary perfusion pressure kept at 60 mmHg, and coronary vascular resistance (CVR) was calculated. After cardiac arrest was induced by tetrodotoxin, the hearts were allocated to one of three temperature groups: 37, 34, and 31˚C (n = 7 for each). All groups received 0.01, 0.1, and 1.0 M of either cromakalim or SNAP or were exposed to isoflurane at 1MAC and 2MAC. Finally, 50 mM of adenosine was administered to obtain maximal coronary vasodilation.Results: CVR significantly increased after cardiac arrest, but did not change after application of each temperature. Cromakalim, SNAP and isoflurane significantly decreased CVR in each temperature group. There were no significant differences in CVR among the three temperature groups with any of the test drugs.

show abstract

“…Previous studies indicate that the hypothermia experienced by the study animals may have enhanced the vasodilation induced by isoflurane. 28,29 Moreover, anaesthesia with isoflurane has been associated with greater hypothermia than ketamine -midazolam or propofol. 30 Finally, there is evidence that etomidate may have contributed to the hypotension as well.…”

Section: Discussionmentioning

confidence: 99%

A novel minimal invasive closed chest myocardial ischaemia reperfusion model in rhesus monkeys (Macaca mulatta): improved stability of cardiorespiratory parameters

et al. 2012

View full text Add to dashboard Cite

The aim of this study was to report the cardiorespiratory events observed during coronary artery occlusion and reperfusion in a minimally invasive closed chest myocardial occlusion-reperfusion model in rhesus monkeys. We hypothesized that a minimally invasive technique may lead to fewer cardiac arrhythmias and complications. Eight male rhesus macaques 10-15 kg and 10-15 years old were sedated with ketamine (2 mg/kg), midazolam (1.3 mg/kg), atropine (0.01 mg/kg) and buprenorphine 0.02 mg/kg intramuscularly. Etomidate 1-2 mg/kg was injected intravenously to allow tracheal intubation. Anaesthesia was maintained with isoflurane. Pulse oximetry, electrocardiogram (ECG), heart rate, mean arterial blood pressure (MAP), inspired isoflurane fractions (F(I)ISO) and core temperature were recorded every 10 min. The coronary artery occlusion was induced by a balloon-tipped catheter advanced via the femoral artery into the left anterior descending artery and inflated to completely occlude the vessel for 20-50 min (IT) before reperfusion. Sequences of elevated ST segment, QRS complex prolongation, ventricular premature complexes and ventricular fibrillation were observed with a lower incidence than previously described in the literature. IT was (min: 17; max: 50) min long. F(I)ISO was lower than the minimal alveolar concentration in these species. Hypotension (MAP < 70 mmHg) and hypothermia (T°C < 36°C) were observed in all macaques. This minimally invasive closed chest model was successful in providing better cardiorespiratory physiological parameters than reported in previous models. The benefit (achieving ischaemia) versus risk (lethal arrhythmia) of the duration of the coronary occlusion should be considered.

show abstract

Mild hypothermia can enhance pial arteriolar vasodilation induced by isoflurane and sevoflurane in cats

Abstract: These results suggest that pial arteriolar vasodilation induced by isoflurane and sevoflurane can be enhanced by mild hypothermia in cats anesthetized with pentobarbital.

Cited by 7 publications

References 35 publications

Hypothermia improves oral and gastric mucosal oxygenation during hypoxic challenges

Hypothermia improves oral and gastric mucosal oxygenation during hypoxic challenges

Direct effect of mild hypothermia on the coronary vasodilation induced by an ATP-sensitive K channel opener, a nitric oxide donor and isoflurane in isolated rat hearts

A novel minimal invasive closed chest myocardial ischaemia reperfusion model in rhesus monkeys (Macaca mulatta): improved stability of cardiorespiratory parameters

Contact Info

Product

Resources

About