Mild iodine deficiency is associated with elevated hearing thresholds in children in Benin

Briel, Tina van den; West, C.E.; Hautvast, J.G.A.J.; Ategbo, Eric Alain

doi:10.1038/sj.ejcn.1601220

Cited by 21 publications

(34 citation statements)

References 19 publications

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“…These results are consistent with the idea that specific spelling disability is a residual problem for individuals who have slow verbal and auditory processing speed and auditory short-term memory difficulties (38). Severe ID is known to result in deaf-mutism and mild ID in reductions in hearing thresholds (39,40) that can be improved by supplementation (41,42). Given that spelling is not remediated by exposure to an iodine-fortified environment in our cohort, we propose that a central auditory processing disorder influencing working memory, rather than a hearing threshold deficit, may be at work.…”

Section: Discussionsupporting

confidence: 80%

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

2015

Prenatal and Childhood Nutrition

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Context:Severe iodine deficiency (ID) during gestation is associated with neurocognitive sequelae. The long-term impact of mild ID, however, has not been well characterized.Objective: The purpose of this study was to determine whether children born to mothers with urinary iodine concentrations (UICs) Ͻ150 g/L during pregnancy have poorer educational outcomes in primary school than peers whose mothers did not have gestational ID (UIC Ն150 g/L).Design: This was a longitudinal follow-up (at 9 years old) of the Gestational Iodine Cohort. Pregnancy occurred during a period of mild ID in the population, with the children subsequently growing up in an iodine-replete environment. Setting and Participants:Participants were children whose mothers attended The Royal Hobart Hospital (Tasmania) antenatal clinics between 1999 and 2001. Main Outcome Measures:Australian national curriculum and Tasmanian state curriculum educational assessment data for children in year 3 were analyzed.Results: Children whose mothers had UIC Ͻ150 g/L had reductions of 10.0% in spelling (Ϫ41.1 points, 95% confidence interval [CI], Ϫ68.0 to Ϫ14.3, P ϭ .003), 7.6% in grammar (Ϫ30.9 points, 95% CI, Ϫ60.2 to Ϫ1.7, P ϭ .038), and 5.7% in English-literacy (Ϫ0.33 points, 95% CI, Ϫ0.63 to Ϫ0.03, P ϭ .034) performance compared with children whose mothers' UICs were Ն150 g/L. These associations remained significant after adjustment for a range of biological factors (maternal age at birth of child, gestational length at time of birth, gestational age at time of urinary iodine collection, birth weight, and sex). Differences in spelling remained significant after further adjustment for socioeconomic factors (maternal occupation and education). Conclusions:This study provides preliminary evidence that even mild iodine deficiency during pregnancy can have long-term adverse impacts on fetal neurocognition that are not ameliorated by iodine sufficiency during childhood. (J Clin Endocrinol Metab 98:

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Section: Discussionsupporting

confidence: 80%

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

2015

Prenatal and Childhood Nutrition

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“…Iodine deficiency probably also affects mental performance through an effect on hearing. In Benin, hearing thresholds were shown to be associated with iodine status as measured by serum thyroglobulin concentrations, while hearing thresholds were negatively associated with performance on mental tests [101]. Studies from China have also shown that excessive intake of iodine can lead to impaired cognitive development [102].…”

Section: R E V I S E Smentioning

confidence: 99%

Effects of Micronutrients during Pregnancy and Early Infancy on Mental and Psychomotor Development

Verhoef¹,

West²,

Bleichrodt³

et al. 2003

Nestl� Nutrition Workshop Series: Pediatric Program

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“…[4][5][6] While the most deleterious effects are seen in areas of severe iodine def iciency, populations in regions of mild iodine def iciency may experience adv erse consequences, such as decreased auditory acuity in children. 7 There is evidence that iodine deficiency has re-emerged in Australia and in other countries, such as the USA, 8,9 where the population once was considered to be replete. In Sydney and Melbourne, mild iodine def iciency has recently been reported in a group of healthy school children, 10,11 healthy adult volunteers, 10,12 pre gnant women, 10,12 postpartum women, 12 patients with diabetes, 10,12 and in neonates.…”

mentioning

confidence: 99%

Persistent iodine deficiency in a cohort of Tasmanian school children: associations with socio-economic status, geographical location and dietary factors

Hynes¹,

Blizzard²,

Venn³

et al. 2004

Aust N Z J Public Health

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Mild iodine deficiency is associated with elevated hearing thresholds in children in Benin

Cited by 21 publications

References 19 publications

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

Effects of Micronutrients during Pregnancy and Early Infancy on Mental and Psychomotor Development

Persistent iodine deficiency in a cohort of Tasmanian school children: associations with socio-economic status, geographical location and dietary factors

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