Mild proteinuria in patients with unilateral kidney

Oberle, G.; Neumann, H. P. H.; Schollmeyer, P.; Boesken, W. H.; Stahl, Rolf A.K.

doi:10.1007/bf01739671

Cited by 16 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Brenner and Mackenzie [5] stated that individuals with URA, who have hyperfiltration from birth, tend to develop proteinuria or systemic hypertension only after their 3rd decade. This theory is supported by reports showing that in adult patients with URA, there is a higher prevalence of albuminuria, proteinuria, hypertension, and renal insufficiency than in the normal population and that these abnormalities are more frequent after a longer follow-up period [24][25][26][27][28] . However, it has to be mentioned that other studies could demonstrate that adults with a solitary kidney since childhood had no adverse effects of longstanding hyperfiltration [29,30] .…”

Section: Discussionsupporting

confidence: 66%

Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis

Seeman

Patzer

John

et al. 2006

Kidney Blood Press Res

View full text Add to dashboard Cite

Background/Aim: Unilateral renal agenesis (URA) is a model for a reduced nephron number that is believed to be a risk factor for blood pressure (BP) elevation and reduced renal function. The aim of the study was to investigate BP and renal function in children with URA. Methods: Data on children with URA from two pediatric nephrology centers were firstly retrospectively reviewed (renal ultrasound and scintigraphy, clinical BP, creatinine clearance, urinalysis). Children with normal renal ultrasound and scintigraphy were thereafter investigated using ambulatory BP monitoring. Results: Twenty-nine children with URA were investigated – 14 children with an abnormal kidney (mostly scarring) and 15 children with healthy kidneys. Hypertension was diagnosed on the basis of clinical BP in 57% of the children with abnormal kidneys and on the basis of ambulatory BP monitoring in 1 child (7%) with healthy kidneys. The mean ambulatory BP in children with normal kidneys was not significantly different from that in controls. Forty-three percent of the children with abnormal kidneys had a reduced renal function, but none of children with normal kidneys. Conclusions: Children with abnormalities of a solitary kidney have often hypertension, proteinuria, or a reduced renal function. In contrast, children with healthy solitary kidneys have BP and renal function similar to those of healthy children.

show abstract

Section: Discussionsupporting

confidence: 66%

Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis

Seeman

Patzer

John

et al. 2006

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

“…In the 1980s, papers by Hostetter et al (35) and others (9) on the consequences of surgical ablation of renal mass sparked new interest in the fate of the living kidney donor. Indeed a number of reports appeared that showed the development of proteinuria in persons with a single kidney (16,20,36) and former kidney donors (10,14). Some authors also found a significant increase in blood pressure after renal donation (9,15,37).…”

Section: Discussionmentioning

confidence: 99%

“…An increase in the amount of protein excreted by the remaining kidney, especially in male donors (14–16), has been found repeatedly (17–21). But in the absence of a correlation between protein excretion and blood pressure or renal function, the clinical significance of this finding remains unclear (12,14,22,23).…”

Section: Introductionmentioning

confidence: 90%

Long‐Term Consequences of Live Kidney Donation Follow‐Up in 93% of Living Kidney Donors in a Single Transplant Center

Goßmann

Wilhelm

Kachel

et al. 2005

American Journal of Transplantation

167

125

View full text Add to dashboard Cite

Live kidney donation is increasing rapidly. Increases of blood pressure and proteinuria but no accelerated loss of renal function in kidney donors have been described. The credibility of this research is hampered by retrieval rates of only 50-70% of donors.We studied renal function, blood pressure, proteinuria, parathyroid hormone, 1,25(OH) 2 cholecalciferol and calcium and phosphate excretion in a live kidney donor cohort with a 93% retrieval rate. A comprehensive physical and laboratory examination including 24-h urine collection was conducted. None of the 152 donors had renal failure. Mean time after uninephrectomy was 11 ± 7 (range: 1-28) years. GFR had declined by 25%. Blood pressure had increased from 125 ± 15/79 ± 11 to 134 ± 19/81 ± 9 mmHg (p < 0.01) but remained significantly below normal. Fifty six percent of donors developed proteinuria (>150 mg/day), but only 10% had albuminuria. Nineteen percent had increased PTH, 30% had a decreased tubular reabsorption rate of phosphate. Regarding risk factors for a higher loss of GFR, greater increases in blood pressure or proteinuria no consistent picture emerged. Because of the high incidence of proteinuria and possible changes in bone metabolism inclusion of kidney donors in registries appears worthwhile.

show abstract

“…However, after approximately 20 years no kidney dysfunction was found in these patients. Oberle et al [39] observed over three-times increased proteinuria in patients after nephrectomy. None of our children developed pathological proteinuria.…”

Section: Discussionmentioning

confidence: 98%

Assessment of serum cystatin C in children with congenital solitary kidney

et al. 2006

View full text Add to dashboard Cite

The aim of the study was to assess serum cystatin C level in children with a congenital solitary kidney, depending on their age and compensatory overgrowth of the kidney. The study group (I) consisted of 36 children, 3-21 years of age (median 10.8 years), with a congenital solitary kidney and no other urinary defects. The control group (C) contained 36 healthy children, 5-21 years old (median 10.9 years). Nephelometric methods were used to determine serum cystatin C level, the Jaffe method to assess creatinine concentration and the Schwartz formula to estimate glomerular filtration rate. Kidney length was measured with the patient in a supine position, and overgrowth was estimated (O%) in comparison with the respective kidney in the control group. Serum cystatin C level in group I was higher than that in the control group (P<0.05). Increased values, above 0.95 mg/l, were found in 16/36 (44%) children aged 12-21 years. Glomerular filtration rate (GFR, estimated by the Schwartz formula) and creatinine level in group I were similar to those of the control group (P>0.05). Increased kidney length was found (median 18.2%). Cystatin C concentration was positively correlated with O% (r=0.406, P<0.01) and kidney length to child height ratio (L/H) (r=0.376, P<0.05). We conclude that Increased serum cystatin C concentration in patients with a unilateral congenital solitary kidney occurs after 12 years of age and correlates with compensatory overgrowth of the kidney.

show abstract

Mild proteinuria in patients with unilateral kidney

Cited by 16 publications

References 8 publications

Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis

Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis

Long‐Term Consequences of Live Kidney Donation Follow‐Up in 93% of Living Kidney Donors in a Single Transplant Center

Assessment of serum cystatin C in children with congenital solitary kidney

Contact Info

Product

Resources

About