Mild restraint reduces the time hormonally primed rats spend with sexually active males

Uphouse, Lynda; Selvamani, Amutha; Lincoln, Christi; Morales, Lauren; Comeaux, Danielle

doi:10.1016/j.bbr.2004.08.001

Cited by 22 publications

(21 citation statements)

References 58 publications

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“…Kaspersen and Agmo (Kaspersen and Agmo, 2012) examined effects of SB 206553 in both paradigms and reported no effect with the exception of a small decline in the number of proceptive behaviors. This contrasts with the report that SB 206553 reduced the time females spent in the male’s compartment(Uphouse et al, 2005) and with the report by Nedergaard et al (Nedergaard et al, 2004) who compared the effects of DOI and MK-212 [6-chloro-2-(1-piperazinyl)pyrazine hydrochloride] as examples of preferential 5-HT 2A and 5-HT 2C receptor agonists, respectively. In the pacing paradigm, DOI reduced the female’s post-ejaculatory return latencies, interpreted as an increase in sexual motivation; and MK-212 increased the female’s latency to approach to the male, interpreted as a decline in sexual motivation (Nedergaard et al, 2004).…”

Section: 0 Drugs Acting At 5-ht Receptorscontrasting

confidence: 81%

Pharmacology of serotonin and female sexual behavior

Uphouse

2014

Pharmacology Biochemistry and Behavior

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In this review, first a historical perspective of serotonin’s (5-HT) involvement in female sexual behavior is presented. Then an overview of studies implicating 5-HT is presented. The effect of drugs that increase or decrease CNS levels of 5-HT is reviewed. Evidence is presented that drugs which increase 5-HT have negative effects on female sexual behavior while a decrease in 5-HT is associated with facilitation of sexual behavior. Studies with compounds that act on 5-HT1, 5-HT2 or 5-HT3 receptors are discussed. Most evidence indicates that 5-HT1A receptor agonists inhibit sexual behavior while 5-HT2 or 5-HT3 receptors may exert a positive influence. There is substantial evidence to support a role for 5-HT in the modulation of female consummatory sexual behavior, but studies on the role of 5-HT in other elements of female sexual behavior (e.g. desire, motivation, sexual appetite) are few. Future studies should be directed at determining if these additional components of female sexual behavior are also modulated by 5-HT.

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Section: 0 Drugs Acting At 5-ht Receptorscontrasting

confidence: 81%

Pharmacology of serotonin and female sexual behavior

Uphouse

2014

Pharmacology Biochemistry and Behavior

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“…In ovariectomized females rats receiving E2 and progesterone (P4) replacement, over-expression of corticotropin-releasing factor (CRF) in the central nucleus of the amygdala inhibits expression of sexual behaviors (Keen-Rhinehart et al, 2009). However, supraphysiological concentrations of E2 can rescue lordosis behavior in rodents following acute exposure to restraint stress (Uphouse et al, 2005; White and Uphouse, 2004), suggesting a balance between the LHPA and LHPG axes. Nevertheless, E2 reinstatement of sexual behavior following stress has only been shown following acute physical restraint, and may not generalize to sexual behavior following chronic exposure to stress.…”

Section: Introductionmentioning

confidence: 99%

Social status modifies estradiol activation of sociosexual behavior in female rhesus monkeys

Reding

Michopoulos

Wallen

et al. 2012

Hormones and Behavior

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Estrogen (E2) has activational effects on sexual motivation and mitigating effects on anxiety-like behaviors that can be attenuated with chronic exposure to psychosocial stress. Some studies suggest that this attenuation can be overcome by higher doses of E2, while others show that chronic psychosocial stress may alter the mechanisms of E2 function, thus reducing any positive benefit from higher doses of E2. To determine the interaction between psychosocial stress and E2 dose on behavior, we examined the scope of attenuation across a suite of socioemotional behaviors, including reproduction, affiliation, aggression, submission, and anxiety-like behaviors on 36 ovariectomized female rhesus monkeys. Females were exposed to graded psychosocial stress, established by an intrinsic female dominance hierarchy, where subordinate animals receive high amounts of harassment. Our data show that E2 dose-dependently increased sexual motivation and male-affiliation in dominant (e.g. low-stress) females, while subordinate females showed no positive effects of E2, even at higher doses. In addition, contact aggression was attenuated in dominant females, while non-contact aggression was attenuated in both dominant and middle-ranking females. These results suggest that the stress-induced attenuation of E2's activational effects on sexual behavior and affiliation with males may not be overcome with higher doses of E2. Furthermore, the observed behavioral consequences of psychosocial stress and E2 dose may be dependent on the behaviors of all the females in the social-group, and better resolution on these effects depends on isolating treatment to individuals within the group to minimize alterations in social-group interactions.

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“…Although a variety of stressors have been reported to influence female rat sexual behavior, the direction of change is not always consistent (Cecconello et al, 2009; Donadio et al, 2007; Gorzalka et al, 1998; Hulse and Coleman, 1983; Uphouse et al, 2008; Uphouse et al, 2005; White and Uphouse, 2004). It is possible that some of this inconsistency may arise from behavioral assessment at different phases of an inhibition/recovery process that is initiated by the stressor.…”

Section: Discussionmentioning

confidence: 98%

Progesterone reduces the inhibitory effect of a serotonin 1B receptor agonist on lordosis behavior

Uphouse

Guptarak

Hiegel

2010

Pharmacology Biochemistry and Behavior

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Ovariectomized Fischer inbred rats were hormonally primed with 10 µg estradiol benzoate and sesame seed oil (EO rats) or with estradiol benzoate and 500 µg progesterone (EP rats). Four to six hr after progesterone or oil, rats were pretested for sexual behavior and then infused bilaterally into the ventromedial nucleus of the hypothalamus with 0, 50, 100 or 200 ng of the 5-HT1B receptor agonist, l,4-dihydro-3-(l,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-bi]pyridin-5-one-dihydrochloride (CP 93129). Sexual receptivity was monitored by the lordosis to mount (L/M) ratio. EO rats showed a transient decline in lordosis behavior following infusion with the saline vehicle and this was amplified by CP 93129. There were no effects of any infusion in EP rats. These findings are discussed in terms of the possible stress effect of the intracranial infusion in EO rats and their implications for a role of 5-HT1B receptors in the response to a mild stress.

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Mild restraint reduces the time hormonally primed rats spend with sexually active males

Cited by 22 publications

References 58 publications

Pharmacology of serotonin and female sexual behavior

Pharmacology of serotonin and female sexual behavior

Social status modifies estradiol activation of sociosexual behavior in female rhesus monkeys

Progesterone reduces the inhibitory effect of a serotonin 1B receptor agonist on lordosis behavior

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