Purpose To determine the effect of various cleaning methods for skin with acute radiation dermatitis (RD) in patients treated for nasopharyngeal carcinoma (NPC).Methods A total of 168 NPC inpatients were randomized, while 152 patients completed the whole trial and the data were analyzed. Patients were randomly divided into non-washing group, washing with water alone group, and washing with water and soap group. All three groups received intensity modulated radiation therapy (IMRT) among other treatments. Follow-up from recruitment or the initial radiotherapy dose to 1 month after the nal radiotherapy dose. CONSORT checklist was applied as the reporting guidelines for this study. Study evaluated a range of endpoints including incidence, timing, severity of acute RD and quality of life (QOL).Results There were no allergic reactions or aggravating in both washing groups during the whole treatment. The incidence of acute RD was 100% in all three groups, while the degree of severity differed among groups. Washing moderately reduced severity compared with patients without washing; washing also delayed the onset time of acute RD, reduced the incidence of moist desquamation and pruritus.There were no signi cant difference among groups with respect to pain or burning sensation. Washing improved QOL on physical, emotional, and social functional dimensions. Washing with water and soap was the most effective on reducing itching and improving QOL among three groups.Conclusion Washing irradiated skin reduces the occurrence and severity of acute radiation dermatitis.