Mild sustained effects of neonatal vasopressin and oxytocin treatment on brain growth and behavior of the rat

Boer, G.J.; Quak, Jacqueline; Vries, Myrtille C. de; Heinsbroek, Rob P.W.

doi:10.1016/0196-9781(94)90007-8

Cited by 27 publications

(17 citation statements)

References 38 publications

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“…In addition to regulating social behavior in adults, it has been hypothesized that OT and AVP have organizational effects on the CNS during early postnatal development (Wang and Young, 1997;Yoshimura et al, 1996;Boer et al, 1994;Shapiro and Insel, 1989). Neonatal manipulation of both OT and AVP can have long-lasting effects.…”

Section: Neuroendocrine Regulation Of Social Behaviormentioning

confidence: 98%

“…While there are fewer studies of the neonatal effects of AVP, a role for AVP in development is also likely. In prairie voles neonatal treatment with AVP was associated with increased aggression in adult males (Stribley and Carter, 1999), while in rats early postnatal treatment with AVP produced changes in open field performance, movement, emotionality and grooming (Boer et al, 1994). Not only do postnatal manipulations of AVP alter subsequent social behavior, manipulations of the preweaning social environment alter subsequent AVP immunoreactivity (IR).…”

Section: Neuroendocrine Regulation Of Social Behaviormentioning

confidence: 99%

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Mechanisms underlying epigenetic effects of early social experience: The role of neuropeptides and steroids

Cushing

Kramer

2005

Neuroscience & Biobehavioral Reviews

177

132

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Section: Neuroendocrine Regulation Of Social Behaviormentioning

confidence: 98%

Section: Neuroendocrine Regulation Of Social Behaviormentioning

confidence: 99%

Mechanisms underlying epigenetic effects of early social experience: The role of neuropeptides and steroids

Cushing

Kramer

2005

Neuroscience & Biobehavioral Reviews

177

132

View full text Add to dashboard Cite

“…Perinatal manipulations of the levels of oxytocin and vasopressin or steroid hormones can alter the long-term programming of oxytocin and vasopressin systems and impact other neurotransmitter systems. This programming phenomenon was first described in rats (Swaab and Boer, 1983;Boer, 1993;Boer et al, 1994) and named 'hormonal imprinting' by Csaba (1986). Reviewed in Bales and Perkeybile (2012), single doses of oxytocin given to newborn prairie vole pups have long-term sex-specific consequences on PVN oxytocin and on other systems such as V1aR and estrogen receptor alpha (Yamamoto et al, 2004(Yamamoto et al, , 2006Kramer et al, 2006;Bales et al, 2007a;Pournajafi-Nazarloo et al, 2007).…”

Section: Oxytocin and Vasopressin Impact Brain Developmentmentioning

confidence: 99%

Developmental Perspectives on Oxytocin and Vasopressin

Hammock

2014

Neuropsychopharmacol

167

146

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The related neuropeptides oxytocin and vasopressin are involved in species-typical behavior, including social recognition behavior, maternal behavior, social bonding, communication, and aggression. A wealth of evidence from animal models demonstrates significant modulation of adult social behavior by both of these neuropeptides and their receptors. Over the last decade, there has been a flood of studies in humans also implicating a role for these neuropeptides in human social behavior. Despite popular assumptions that oxytocin is a molecule of social bonding in the infant brain, less mechanistic research emphasis has been placed on the potential role of these neuropeptides in the developmental emergence of the neural substrates of behavior. This review summarizes what is known and assumed about the developmental influence of these neuropeptides and outlines the important unanswered questions and testable hypotheses. There is tremendous translational need to understand the functions of these neuropeptides in mammalian experience-dependent development of the social brain. The activity of oxytocin and vasopressin during development should inform our understanding of individual, sex, and species differences in social behavior later in life.

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“…In prairie voles, a single injection of OT on the day of birth affects aggressive behaviour (Carter 2003) and male alloparenting rates (Bales et al 2004). Likewise, administration of AVP soon after birth increases aggressive behaviour in adult male prairie voles (Stribley & Carter 1999) and changes risk-taking and social behaviour in rats (Boer et al 1994). Furthermore, in California mice (Peromyscus californicus), social experiences during the pre-weaning period (being raised by either monogamous conspecifics or by closely related polygynous P. leucopus) changed the aggressive behaviour expressed by these mice as adults with corresponding changes in brain AVP expression (Bester-Meredith & Marler 2001).…”

Section: Variation In Cooperative Behaviour: Integrating Hormones Andmentioning

confidence: 99%

Hormonal mechanisms of cooperative behaviour

Soares

Bshary

Fusani

et al. 2010

Phil. Trans. R. Soc. B

147

143

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Research on the diversity, evolution and stability of cooperative behaviour has generated a considerable body of work. As concepts simplify the real world, theoretical solutions are typically also simple. Real behaviour, in contrast, is often much more diverse. Such diversity, which is increasingly acknowledged to help in stabilizing cooperative outcomes, warrants detailed research about the proximate mechanisms underlying decision-making. Our aim here is to focus on the potential role of neuroendocrine mechanisms on the regulation of the expression of cooperative behaviour in vertebrates. We first provide a brief introduction into the neuroendocrine basis of social behaviour. We then evaluate how hormones may influence known cognitive modules that are involved in decision-making processes that may lead to cooperative behaviour. Based on this evaluation, we will discuss specific examples of how hormones may contribute to the variability of cooperative behaviour at three different levels: (i) within an individual; (ii) between individuals and (iii) between species. We hope that these ideas spur increased research on the behavioural endocrinology of cooperation.

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Mild sustained effects of neonatal vasopressin and oxytocin treatment on brain growth and behavior of the rat

Cited by 27 publications

References 38 publications

Mechanisms underlying epigenetic effects of early social experience: The role of neuropeptides and steroids

Mechanisms underlying epigenetic effects of early social experience: The role of neuropeptides and steroids

Developmental Perspectives on Oxytocin and Vasopressin

Hormonal mechanisms of cooperative behaviour

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