Mild traumatic brain injury and fatigue: A prospective longitudinal study

Norrie, Joan; Heitger, Marcus; Leathem, Janet; Anderson, Tim; Jones, Richard D.; Flett, Ross

doi:10.3109/02699052.2010.531687

Cited by 111 publications

(107 citation statements)

References 68 publications

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“…Moreover, it was common for the patients' friends and family members to consider fatigue as 'laziness' or 'apathy'. In a longitudinal prospective study, Norrie et al (8) revealed that a potentially unsupportive interpretation of fatigue-related behaviors as 'laziness' or 'unwillingness' by family members or friends was reported by up to 30% of all participants. In addition, due to the continuing demands on time and excessive responsibilities of management by patients with persistent fatigue, caregivers of these patients were at increased risk of poor psychosocial outcomes (28).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, in the current study complete follow up data on fatigue, on which the fatigue analysis was based, was available for only 77.2% of the originally included individuals. This might have resulted in an overestimation of the actual prevalence of fatigue, as the participants who continued with the follow up were more likely to be those having fatigue (8).…”

Section: Discussionmentioning

confidence: 99%

“…It was observed previously that strengthening of social support and improving its perception could alleviate some psychosocial factors including depression and anxiety (13,14), which were identified as common consequences of acquired brain injuries and major contributors of mental fatigue (8,15). Moreover, an intervention on supportive relationships delivered through several rehabilitation programs appeared to result in considerable improvement of life satisfaction and reduction of adverse psychological outcomes (16,17).…”

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confidence: 98%

“…Most persons experiencing post-MTBI fatigue can spontaneously recover shortly after injury (8). However, it may persist for months even years requiring long-term medical care (8).…”

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confidence: 99%

“…However, it may persist for months even years requiring long-term medical care (8). Determining the protocol for the management of longlasting fatigue remains complex and challenging for both clinicians and researchers, as further improvement from this ailment seems very difficult (9).…”

mentioning

confidence: 99%

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Perceived Social Support and Its Impact on Mental Fatigue in Patients with Mild Traumatic Brain Injury

Zeng¹,

Zeng²,

Tian³

et al. 2016

Balkan Med J

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Background: Although mental fatigue was well-recognized as one of the long-term consequences following mild traumatic brain injury (MTBI) that required ongoing support, evidences for the optimal management remained inadequate. Aims: To investigate the temporal profile of mental fatigue during the first year after MTBI and examine the impact of perceived social support on the recovery from post-MTBI fatigue. Study Design: Observational case-control study. Methods: This study was conducted among post-MTBI patients admitted to the emergency department in a tertiary-care hospital in Sichuan, China. During four waves of assessments at 1 week, 3, 6 and 12 months, mental fatigue was assessed through Mental Fatigue Scale (MFS) whereas social support was assessed by the Multidimensional Scale of Perceived Social Support (MSPSS).Results: There were 65.1%, 37.1%, 34.8% and 32.5% individuals being identified as those with mental fatigue at 1 week, 3, 6 and 12 months, respectively. The scores of MFS didn't change substantially since 3 months post-injury. Compared to non-fatigued MTBI patients, those with long-lasting post-MTBI fatigue reported extremely lower level of perceived social support. Moreover, improved social support at 1 week was negatively associated with the occurrence of long-lasting fatigue. Conclusion: Sufficient social support could significantly decrease the occurrence of long-lasting mental fatigue among MTBI cases. It seemed of great importance to modify the emphasis of rehabilitation to include assessment and improvement of perceived social support at earlier stages after injury.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

“…Most persons experiencing post-MTBI fatigue can spontaneously recover shortly after injury (8). However, it may persist for months even years requiring long-term medical care (8).…”

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Perceived Social Support and Its Impact on Mental Fatigue in Patients with Mild Traumatic Brain Injury

Zeng¹,

Zeng²,

Tian³

et al. 2016

Balkan Med J

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Association of Traumatic Brain Injury With the Risk of Developing Chronic Cardiovascular, Endocrine, Neurological, and Psychiatric Disorders

et al. 2022

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Persistent neurologic symptoms and cognitive dysfunction in non‐hospitalized Covid‐19 “long haulers”

Graham

Clark

Orban

et al. 2021

Ann Clin Transl Neurol

545

551

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Objective Most SARS‐CoV‐2‐infected individuals never require hospitalization. However, some develop prolonged symptoms. We sought to characterize the spectrum of neurologic manifestations in non‐hospitalized Covid‐19 “long haulers”. Methods This is a prospective study of the first 100 consecutive patients (50 SARS‐CoV‐2 laboratory‐positive (SARS‐CoV‐2+) and 50 laboratory‐negative (SARS‐CoV‐2‐) individuals) presenting to our Neuro‐Covid‐19 clinic between May and November 2020. Due to early pandemic testing limitations, patients were included if they met Infectious Diseases Society of America symptoms of Covid‐19, were never hospitalized for pneumonia or hypoxemia, and had neurologic symptoms lasting over 6 weeks. We recorded the frequency of neurologic symptoms and analyzed patient‐reported quality of life measures and standardized cognitive assessments. Results Mean age was 43.2 ± 11.3 years, 70% were female, and 48% were evaluated in televisits. The most frequent comorbidities were depression/anxiety (42%) and autoimmune disease (16%). The main neurologic manifestations were: “brain fog” (81%), headache (68%), numbness/tingling (60%), dysgeusia (59%), anosmia (55%), and myalgias (55%), with only anosmia being more frequent in SARS‐CoV‐2+ than SARS‐CoV‐2‐ patients (37/50 [74%] vs. 18/50 [36%]; p < 0.001). Moreover, 85% also experienced fatigue. There was no correlation between time from disease onset and subjective impression of recovery. Both groups exhibited impaired quality of life in cognitive and fatigue domains. SARS‐CoV‐2+ patients performed worse in attention and working memory cognitive tasks compared to a demographic‐matched US population (T‐score 41.5 [37, 48.25] and 43 [37.5, 48.75], respectively; both p < 0.01). Interpretation Non‐hospitalized Covid‐19 “long haulers” experience prominent and persistent “brain fog” and fatigue that affect their cognition and quality of life.

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Mild traumatic brain injury and fatigue: A prospective longitudinal study

Abstract: Post-MTBI fatigue is a persistent post-concussion symptom, exacerbated by depression but not anxiety. It diminishes in the first 3 months and then becomes relatively stable, suggesting the optimum intervention placement is at 3 months or more post-MTBI.

Cited by 111 publications

References 68 publications

Perceived Social Support and Its Impact on Mental Fatigue in Patients with Mild Traumatic Brain Injury

Perceived Social Support and Its Impact on Mental Fatigue in Patients with Mild Traumatic Brain Injury

Association of Traumatic Brain Injury With the Risk of Developing Chronic Cardiovascular, Endocrine, Neurological, and Psychiatric Disorders

Persistent neurologic symptoms and cognitive dysfunction in non‐hospitalized Covid‐19 “long haulers”

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