Milestones in the treatment of hepatocellular carcinoma: A systematic review.

Gryziak, Maciej; Woźniak, Krzysztof; Kraj, Leszek; Stec, Rafał

doi:10.1016/j.critrevonc.2020.103179

Cited by 15 publications

(12 citation statements)

References 38 publications

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“…As the third leading cause of cancer-related deaths worldwide, hepatocellular carcinoma (HCC) is difficult to combat due to its high degree of malignancy and poor prognosis ( 39 ). Immunotherapy has brought hope for the treatment of HCC ( 40 ). To assess the immune microenvironment in HCC and identify innovative biomarkers for immunotherapy of HCC, T cells in HCC tissues were analyzed by scRNA-seq, and T-cell subpopulations were reviewed in a transcriptional map.…”

Section: Single-cell Sequencing In Cancer: Lessons Learnedmentioning

confidence: 99%

The Single-Cell Sequencing: A Dazzling Light Shining on the Dark Corner of Cancer

et al. 2021

Front. Oncol.

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Tumorigenesis refers to the process of clonal dysplasia that occurs due to the collapse of normal growth regulation in cells caused by the action of various carcinogenic factors. These “successful” tumor cells pass on the genetic templates to their generations in evolutionary terms, but they also constantly adapt to ever-changing host environments. A unique peculiarity known as intratumor heterogeneity (ITH) is extensively involved in tumor development, metastasis, chemoresistance, and immune escape. An understanding of ITH is urgently required to identify the diversity and complexity of the tumor microenvironment (TME), but achieving this understanding has been a challenge. Single-cell sequencing (SCS) is a powerful tool that can gauge the distribution of genomic sequences in a single cell and the genetic variability among tumor cells, which can improve the understanding of ITH. SCS provides fundamental ideas about existing diversity in specific TMEs, thus improving cancer diagnosis and prognosis prediction, as well as improving the monitoring of therapeutic response. Herein, we will discuss advances in SCS and review SCS application in tumors based on current evidence.

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Section: Single-cell Sequencing In Cancer: Lessons Learnedmentioning

confidence: 99%

The Single-Cell Sequencing: A Dazzling Light Shining on the Dark Corner of Cancer

et al. 2021

Front. Oncol.

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“…It is estimated that 840,000 newly diagnosed HCC cases are reported each year worldwide ( 3 ). Liver resection is commonly radical treatment ( 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Does Chronic Kidney Disease Really Affect the Complications and Prognosis After Liver Resection for Hepatocellular Carcinoma? A Meta-Analysis

et al. 2022

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PurposeThe purpose of this meta-analysis was to analyze whether chronic kidney disease (CKD) affected the complications and prognosis after liver resection for hepatocellular carcinoma.MethodsThe PubMed, Embase, and Cochrane Library databases were searched from inception to 22 February 2022 to find eligible studies. Complications, overall survival (OS), and disease-free survival (DFS) were collected, and this meta-analysis was performed with RevMan 5.3.ResultsA total of nine studies including 6,541 patients were included in this meta-analysis. After pooling all baseline information, the CKD group had a higher rate of Child-Pugh grade B than the Non-CKD group (OR = 1.58, 95% CI = 1.3 to 1.93, P < 0.00001). As for surgery-related information, the CKD group had larger blood loss (MD = −404.79, 95% CI = −509.70 to −299.88, P < 0.00001), and higher rate of blood transfusion (OR = 2.47, 95% CI = 1.85 to 3.3, P < 0.00001). In terms of complications, the CKD group had a higher rate of overall complications (OR = 2.1, 95% CI = 1.57 to 2.81, P < 0.00001) and a higher rate of ≥ grade III complications (OR = 2.04, 95% CI = 1.57 to 2.81, P = 0.0002). The CKD group had poor OS compared with the non-CKD group (HR = 1.28, 95% CI = 1.1 to 1.49, P = 0.001). However, in terms of DFS, no significant difference was found (HR = 1.11, 95% CI = 0.96 to 1.28, P = 0.16).ConclusionPreexisting CKD was associated with higher ratio of complications and poor OS.

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“…3 Despite the promising recent developments in the role of immunotherapy for HCC, the treatments for advanced HCC remain largely palliative. 4 Therefore, it is crucial to identify factors that modify the risk of HCC, as they may provide insight into novel preventative or therapeutic options. Atopic dermatitis, asthma, and allergic rhinitis are the most prevalent allergic diseases worldwide, and their physiology is de ned by IgE-mediated immunological hyperresponsiveness.…”

Section: Introductionmentioning

confidence: 99%

Association of allergic disease with subsequent risk of liver cancer: A nation-wide cohort study

Kim

Choi

Chang

et al. 2022

Preprint

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Background : Studies have proposed an inverse association between allergic diseases and cancer risk, but few studies to date have specifically investigated the risk of primary liver cancer (hepatocellular carcinoma, HCC; intrahepatic cholangiocarcinoma, ICC) in patients with or without allergic diseases. Objective : The aim of this study was to evaluate the association between allergic diseases and risk of developing liver cancer.Methods: A retrospective cohort study of the Korean National Health Insurance Service database was performed to study 405,512 South Korean adults ages 40 and above who underwent routine health screening after January 1st, 2005. All participants were followed for liver cancer diagnosis or death until December 31st, 2013. Those who died before the index date, had pre-diagnosed cancer, or did not undergo health screening were excluded. Cox proportional hazards regression was performed to determine the adjusted hazard ratios(aHRs) and 95% confidence intervals (CIs) for risk of developing liver cancer according presence or absence of atopic dermatitis, asthma and allergic rhinitis.Results: The aHR (95% CI) for overall liver cancer among allergic patients was 0.72 (0.64-0.81). Allergic patients had significantly reduced risk of HCC (aHR: 0.70, 95% CI: 0.61-0.81) but not ICC (aHR: 0.99, 95% CI: 0.71-1.08). Presence of allergic diseases was associated with significantly lower risk of liver cancer in both patients with (aHR: 0.61, 95% CI: 0.47-0.8) or without (aHR: 0.74, 95% CI: 0.65-0.85) chronic Hepatitis B/C infections. Presence of allergic diseases was associated with significantly lower risk of liver cancer in patients without cirrhosis (aHR: 0.72, 95% CI 0.63-0.82), but not in those with cirrhosis (aHR: 0.98, 95% CI 0.68-1.41). Patients with multiple allergies had even lower risk of liver cancer compared to patients with single allergy. Conclusion: Patients with allergic diseases have significantly lower risk of developing liver cancer compared to those without allergic diseases, which supports the rationale for immunotherapy as an effective treatment of liver cancer.

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Milestones in the treatment of hepatocellular carcinoma: A systematic review.

Cited by 15 publications

References 38 publications

The Single-Cell Sequencing: A Dazzling Light Shining on the Dark Corner of Cancer

The Single-Cell Sequencing: A Dazzling Light Shining on the Dark Corner of Cancer

Does Chronic Kidney Disease Really Affect the Complications and Prognosis After Liver Resection for Hepatocellular Carcinoma? A Meta-Analysis

Association of allergic disease with subsequent risk of liver cancer: A nation-wide cohort study

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