Human teeth play an important role in facial aesthetics. The modern society trends for more and more demanding aesthetics strongly reflect in teeth appearance. Perfect shaped, aligned, and white teeth are considered the business card of an appealing smile. Fixed prosthetics not only aim to restore the lost function of human teeth but also their aesthetics. The ideal in this matter is to provide an indirect restoration that perfectly matches the neighboring teeth or aims to improve the overall appearance of the patient’s teeth, depending on the situation. However, the choice of aesthetic materials and technologies has experienced a significant development in recent years. By far, dental ceramics are the state-of-the-art material when a high-quality indirect fixed prosthetic restoration is the goal. This chapter will provide information on this class of materials and their indications in fixed prosthodontics, focusing on novel manufacturing technologies, as well.