Milia-like calcinosis cutis in a girl with Down syndrome

Solak, Berna; Kara, Rabia Öztaş; Vargöl, Erdem

doi:10.1590/abd1806-4841.20164560

Cited by 7 publications

(5 citation statements)

References 8 publications

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“…Thirteen case reports and 1 case series reported 15 patients with calcinosis cutis, where 12 were diagnosed with milia-like calcinosis cutis [89][90][91][92][93][94][95][96][97][98][99][100], 1 with dystrophic calcinosis cutis [101], and 1 unspecified case (Multimedia Appendix 8) [102]. There were no reports of abnormal laboratory values, including serum calcium, phosphate, and parathyroid hormone levels.…”

Section: Calcinosis Cutismentioning

confidence: 99%

Common Dermatologic Disorders in Down Syndrome: Systematic Review

Lam¹,

Lu²,

Elhadad³

et al. 2022

JMIR Dermatol

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Background Down syndrome (DS) has been associated with cardiovascular, gastrointestinal, and immune-related abnormalities. Several dermatologic conditions, including hidradenitis suppurativa, have also been found to be associated with DS. Objective The objective of this study was to characterize the prevalence, presentation, and unique features of dermatologic disorders associated with DS. Methods Electronic searches of EMBASE (via Ovid), MEDLINE (via Ovid), and Web of Science databases were conducted on December 14, 2020. Observational studies including case reports of patients with DS presenting with concomitant primary dermatologic disorder were included. Results This systematic review captured 40 observational studies and 99 case reports, including 10 observational studies that examined the prevalence of common skin disorders in patients with DS. The most common dermatologic conditions reported includes atopic dermatitis (8 studies, n=180; 19.7% mean prevalence), hidradenitis suppurativa (15, n=478; 3.2%), ichthyosis (4, n=16; 4.7%), lichen nitidus (6, n=6; 1.1%), psoriasis (21, n=65; 4.8%), alopecia areata (27, n=253; 7.4%), vitiligo (8, n=40; 4.4%), onychomycosis (3, n=198; 24.7%), calcinosis cutis (14, n=15), connective tissue nevi (6, n=6), dermatofibroma (3, n=3), melanoma (3, n=3), syringomas (14, n=182; 21.2%), and elastosis perforans serpiginosa (19, n=24; 0.5%). Conclusions Our results indicate an increased prevalence of common cutaneous disorders in patients with DS, particularly infectious, inflammatory, autoimmune, and connective tissue conditions. Current guidelines for the screening, general management, and use of systemic immunomodulatory agents in this patient population are lacking. Patients with DS would benefit from screening for dermatologic disorders not otherwise regularly performed for earlier diagnosis and treatment. Trial Registration PROSPERO International Prospective Register of Systematic Reviews CRD42021226295; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=226295

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Section: Calcinosis Cutismentioning

confidence: 99%

Common Dermatologic Disorders in Down Syndrome: Systematic Review

Lam¹,

Lu²,

Elhadad³

et al. 2022

JMIR Dermatol

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“…The term idiopathic calcifi cation refers to skin calcifi cation that is not associated with underlying tissue injury or a systemic disorder [ 2 ] . Milia-like idiopathic calcinosis affects both sexes equally and usually occurs during childhood [ 3,4 ] . Prior reports suggested that MICC lesions are primarily seen on the hands and feet but may occur elsewhere [ 4 ] .…”

Section: Milia-like Calcinosis Cutismentioning

confidence: 99%

“…Milia-like idiopathic calcinosis affects both sexes equally and usually occurs during childhood [ 3,4 ] . Prior reports suggested that MICC lesions are primarily seen on the hands and feet but may occur elsewhere [ 4 ] . Only a few reports have mentioned facial lesions [5][6][7] .…”

Section: Milia-like Calcinosis Cutismentioning

confidence: 99%

White papules on the eyelids and dorsa of the hands in an 8‐year‐old Ethiopian girl

Smets

Coninck

Hillary

2019

J Deutsche Derma Gesell

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“…Die Milia-like idiopathic calcinosis cutis (MICC) ist eine Unterform der idiopathischen Calcinosis cutis unklarer Ethiologie und Pathogenese mit normalen Serumwerten von Calcium und Phosphat und etwa gleicher Geschlechterverteilung. Zwei Drittel der beschriebenen Fälle zeigen eine Assoziation zum Down-Syndrom 1 2 3 4 5 . Betroffene (meist Kindesalter) zeigen milienartige Calciumablagerungen in der Haut mit Bevorzugung der Extremitäten 1 2 .…”

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“…Betroffene (meist Kindesalter) zeigen milienartige Calciumablagerungen in der Haut mit Bevorzugung der Extremitäten 1 2 . Histopathologisch stellen sich gut-abgegrenzte basophile calciumhaltige Knötchen in der oberen Hautschicht dar, welche von dicken Kollagenfasern, Epitheloidzellen und mehrkernigen Riesenzellen umgeben sind 1 2 3 . Die MICC zeigt eine Spontanheilung bis zum Erwachsenenalter 2 5 .…”

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