Milia-like idiopathic calcinosis cutis: an unusual dermatosis associated with Down syndrome

Schepis, Carmelo; Siragusa, Maddalena; Palazzo, Rosaria; Batolo, D; Romano, Corrado

doi:10.1111/j.1365-2133.1996.tb07855.x

Cited by 28 publications

(30 citation statements)

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“…Syringeal structures seem to be the organizing sites of the calcified nodule [24]. Then, the content dilates the acrosyringium and is cleaved in the upper dermis and eventually expelled by a perforation [25]. Milia-like idiopathic calcinosis cutis is associated coincidentally with palpebral syringomas [26].…”

Section: Discussionmentioning

confidence: 99%

An Updated Survey on Skin Conditions in Down Syndrome

et al. 2002

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Background: Only three not concordant surveys have been published on skin conditions associated with Down syndrome. Objective: A sample ranging from infancy to adulthood, using acknowledged criteria for diagnosis, may highlight the skin involvement in Down syndrome. Methods: We report the skin conditions observed in 203 people with Down syndrome, separated according to five different age ranges. We have set up two main groups of skin features: the phenotype and the dermatological diseases. Results: The single palmar crease and xerosis are strongly represented within the phenotype. Among the dermatological diseases, folliculitis and syringomas have been observed mainly in adolescence and adulthood. Atopic dermatitis has been recognized in 10 subjects. Alopecia areata and milia-like idiopathic calcinosis cutis appeared in 6 subjects. Conclusion: People with Down syndrome suffer from peculiar dermatoses (syringomas, milia-like calcinosis, elastosis perforans serpiginosa). Other conditions (folliculitis, alopecia areata) are frequently observed.

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Section: Discussionmentioning

confidence: 99%

An Updated Survey on Skin Conditions in Down Syndrome

et al. 2002

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“…33 MICC, like elastosis perforans serpiginosa and some cases of calcinosis cutis, shows perforation and has been reported in DS. 34 …”

Section: Milia-like Idiopathic Calcinosis Cutis (Micc)mentioning

confidence: 99%

Dermatological Manifestations of Down's Syndrome

Barankin

Guenther

2001

Journal of Cutaneous Medicine and Surgery: Incorporating Medica

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Background: Down's syndrome (DS) is an extensively researched congenital condition characterized by mental retardation and distinct physical features. The cutaneous manifestations of DS are numerous, yet they seldom receive appropriate attention.Objective: To review the dermatological conditions associated with DS.Methods: A review of the medical literature.Results: DS is associated with an increased incidence of numerous dermatological conditions, some of which may be related to an immunological deficiency.Conclusion: Along with the importance of understanding the physical and psychosocial aspects of DS, an appreciation of the dermatological manifestations of this condition is integral to comprehensive medical care.

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“…MICC has been reported sometimes in association with ocular [8]or perilesional syringomas [7]. MICC starts at the pediatric age and fades in adolescence.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors suspected that the syringeal structure could be the first site of calcification [14]subsequently cleaved in the upper dermis and expelled by perforation [7]. …”

Section: Discussionmentioning

confidence: 99%

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Eruptive Syringomas with Calcium Deposits in a Young Woman with Down’s Syndrome

et al. 2001

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Eruptive syringomas are uncommon in the general population. We describe here an 18-year-old female, affected by Down’s syndrome, who presented with an abrupt eruption of small skin-colored or reddish papules on the face, neck and limbs. Light microscopy allowed us to diagnose syringomas, whereas the study of the ultrastructural features revealed calcium deposits in many lumina and also in the mitochondria. This observation confirms the hypothesis that the syringeal structure plays a role in the pathogenesis of calcinosis cutis.

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Milia-like idiopathic calcinosis cutis: an unusual dermatosis associated with Down syndrome

Cited by 28 publications

References 12 publications

An Updated Survey on Skin Conditions in Down Syndrome

An Updated Survey on Skin Conditions in Down Syndrome

Dermatological Manifestations of Down's Syndrome

Eruptive Syringomas with Calcium Deposits in a Young Woman with Down’s Syndrome

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