Miliary breast cancer brain metastasis: a rare and aggressive form of central nervous system metastasis

Mills, Matthew; Ahmed, Kamran A.

doi:10.1038/s41416-020-1001-9

Cited by 3 publications

(2 citation statements)

References 17 publications

(34 reference statements)

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“…1, 3 However, these disseminated lesions in the context of brain metastases originate from various primary cancers, including but not limited to breast, lung, and gastrointestinal tumors. [4][5][6][7][8][9] Despite the significant burden that brain metastases impose on patients' quality of life and survival, the unique subset of miliary cerebral metastases remains poorly understood. 10, 11 The exact incidence of miliary cerebral metastases is uncertain, primarily due to its rarity, and it is thought to represent only a small fraction of all brain metastases.…”

Section: Introductionmentioning

confidence: 99%

Miliary cerebral metastases: prevalence and radiological findings

YALTIRIK BİLGİN,

ÜNAL

2023

J Health Sci Med /JHSM /jhsm

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Aims: Miliary cerebral metastases, also known as carcinomatosis encephalitis, represent an unusual form of metastatic disease in the brain. Due to their rarity, limited literature is available, restricting our understanding of this condition. This study aimed to evaluate the prevalence and imaging characteristics of miliary cerebral metastases in a cohort of metastatic patients. Methods: A retrospective review was conducted on approximately 618 contrast-enhanced MRI scans from patients with metastatic disease who had not undergone surgical intervention or received radiotherapy. Cases of miliary cerebral metastases were identified and analyzed. Demographic data, primary cancer types, non-contrast CT and MRI findings of miliary metastasis cases were evaluated. Results: Miliary cerebral metastases were identified in 6 out of the 618 metastatic patients included in the study. The radiological features included small, disseminated hyperintense lesions visible on post-contrast T1-weighted images. These lesions were diffusely scattered throughout the brain, predominantly at the grey-white matter junction. Conclusion: Our findings highlight the rarity of miliary cerebral metastases, supporting the limited cases reported in the literature. These findings underscore the need for increased clinical awareness and further research into this condition. High-resolution, contrast-enhanced MRI plays a vital role in detecting and characterizing miliary cerebral metastases, aiding in their management.

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Section: Introductionmentioning

confidence: 99%

Miliary cerebral metastases: prevalence and radiological findings

YALTIRIK BİLGİN,

ÜNAL

2023

J Health Sci Med /JHSM /jhsm

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“…There are no universally accepted criteria by which to make the diagnosis, but because tissue is rarely available, MRI criteria have been proposed. Distinguishing miliary from intraparenchymal disease may significantly alter a treatment plan as the former trends toward worsened prognoses and requires distinct therapies . Knowledge of and consideration of this process may contribute to more rapid diagnoses via MRI or, in cases where clinicians are reluctant to accept imaging-weighted criteria, earlier consideration of brain biopsy.…”

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confidence: 99%

Carcinomatosis Encephalitis Secondary to Neuroendocrine Transformation of Prostate Cancer

Melendez-Zaidi

Fuller

2021

JAMA Neurol

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A Rare Case of Large-Cell Neuroendocrine Carcinoma Metastasizing to the Brain: A Case Report

Mohamed,

Salih,

Suliman

et al. 2024

Cureus

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Neuroendocrine tumors (NETs) encompass a diverse spectrum of neoplasms that can originate from various sites, including the gastrointestinal tract. Brain metastases from neuroendocrine tumors, while rare, present significant clinical challenges. In this case report, we present the unique instance of a 50-year-old female with a history of gastrointestinal neuroendocrine tumor who manifested left-sided weakness, tremors, and recurrent focal convulsions. Initial imaging scans revealed a lesion in the right parietal lobe, which was surgically excised and diagnosed as a metastatic large-cell neuroendocrine carcinoma. Post-surgery, the patient's condition stabilized, but she was subsequently advised to chemotherapy. This case underscores the infrequency of brain metastases in the context of gastrointestinal neuroendocrine tumors, underscoring the need for comprehensive screening in such scenarios. Given the aggressive nature of neuroendocrine carcinomas and their propensity to disseminate to the brain, early detection and intervention are crucial. Our rare case also underscores the importance of distinguishing high-grade neuroendocrine carcinomas, which necessitate intensive management, from less aggressive NETs and other metastatic neoplasms that have different treatment approaches.

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Miliary breast cancer brain metastasis: a rare and aggressive form of central nervous system metastasis

Cited by 3 publications

References 17 publications

Miliary cerebral metastases: prevalence and radiological findings

Miliary cerebral metastases: prevalence and radiological findings

Carcinomatosis Encephalitis Secondary to Neuroendocrine Transformation of Prostate Cancer

A Rare Case of Large-Cell Neuroendocrine Carcinoma Metastasizing to the Brain: A Case Report

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