Miliary Tuberculosis due to Intravesical Bacillus Calmette-Guerin Therapy

Nearly Fatal Complications of Cervical Lymphadenitis following BCG Immunotherapy for Superficial Bladder Cancer

“…In a series of 2,602 patients, local complications of BCG immunotherapy occurred in about 3% of patients [2]. General side effects like fever, renal abscess, sepsis and BCG-induced pulmonary [3, 4, 5]and miliary tuberculosis [6, 7]are rare and mainly reported in the form of case reports. Therefore the true incidence of systemic side effects remains unknown.…”

Disseminated Pulmonary Granulomas after Intravesical Bacillus Calmette-Guérin Immunotherapy

“…Systemic serious complications may not be apparent until several weeks after BCG administration. They in clude disseminated BCG infection in distant organs [8][9][10][11] (granulomatous hepatitis, prostatitis, renal abscess, retroperitoneal lymphadenopathy and miliary pulmonary disease) or systemic hypersensitivity reactions [12] (pan cytopenia, fever, hepatitis, pneumonitis, renal insuffi ciency). Ten fatal cases have been reported with sepsis or anaphylaxis related to intravesical use [13].…”

“…Cultures of lung tissue of this patient grew BCG organisms. Gupta et al [11] reported 1 case of 'miliary tuberculosis' in 1 patient while receiving intrave sical BCG.…”

Meningitis Due to Iatrogenic Bcg Infection in Two Immunocompromised Children

“…4 More severe complications are rare and can include pneumonitis, hepatitis, abscess of the psoas muscle, and sepsis. [16][17][18][19] Only a few cases of central nervous system infection due to BCG have been reported. BCG meningitis developed in three immunocompetent children five to six months after vaccination.…”