Miliary Tuberculosis in a Case of Acute Disseminated Lupus Erythematosus Treated with A.C.T.H

The Role of Adrenocorticotrophic and Adrenocorticosteroid Hormones in the Treatment of Tuberculosis

“…(6) Upon rare occasion, the administration of steroid hormones has been known to mask a serious allergic reaction which has co-ne to light only upon diminishing the dose or discontinuing the hormones. (7) Several controlled clinical trials of steroid hormones in the treatment of pulmonary tuberculosis have now been reported. Modest doses for relatively long periods of time have resulted in a dramatic acceleration of response to treatment.…”

Acute Disseminated Lupus Erythematosus in a Child

“…The X-ray evidence of pulmonary infiltrations was disturbing in view of the child's close contact with a Sl fferer from active tuberculosis. The pathogenesis of acute disseminated lupus erythematosus and that of pulmonary tuberculosis appear to be unrelated, although cases are reported in which either these diseases coexisted (Tumulty and Harvey, 1949), or the administration of ACTH or cortisone activated a latent tuberculosis focus (Walker, 1952;Harris-Jones and Pein, 1952). A sLrvey of the literature of acute disseminated lupus erythematosus by Rapaport et alii (1953) showed that, although pulmonary lesions are common, they are frequently atypical and difficult to evaluate; these authors suggest that the lungs may be as common a site of initial involvement as are the heart, kidneys and serous membranes.…”