Genital scarring is a topic rarely addressed and discussed in public. Scarring can occur after trauma, female genital mutilation/cutting, circumcision, tumor surgery, burns, infections, or local skin diseases, for example, lichen sclerosus et atrophicus. Genital skin anatomy and wound healing differ from other regions of the body. This chapter focuses on genital skin anatomy, the physiology of normal genital wound healing, the pathophysiology of genital scarring, and the current state-of-the-art for plastic surgical treatment of genital tissue defects and scars.