Milk activates the expression of cytokines via Nrf2/HO‐1 pathway in human periodontal ligament cells

Abstract

Within the limit of this study, this study demonstrates that exposure of PDL cells to milk is associated with an upregulated expression of several pro-inflammatory proteins and key antioxidant proteins via the activation of Nrf2/ARE pathway in PDL cells.

Which is the most recommended medium for the storage and transport of avulsed teeth? A systematic review

“…A further three studies also recommend milk and HBSS along with different natural products . Twenty‐one studies recommended milk in some form in addition to the other media tested, while 13 of these studies exclusively recommended milk . HBSS was found to be the second most recommended individual medium in 16 studies .…”

Effect of propolis on preserving human periodontal ligament cells and regulating pro‐inflammatory cytokines

“…This result was consistent with protein production results. Previous reports showed that pro‐inflammatory cytokines were highly expressed when hPDLCs were kept in milk . Another study found that IL‐1 β expression was upregulated in the co‐culture of mouse periodontal ligament cells and RAW macrophage‐like cells kept in milk for 6 hour.…”

Comparative evaluation of periodontal ligament fibroblasts stored in different types of milk: effects on viability and biosynthesis of collagen

“…So far, HBSS and milk are still the tooth‐preserving solutions recommended as a result of their characteristics and ability to maintain the viability of PDLFs . Nevertheless, each has some disadvantages: HBSS is not easily accessible at the scene of accidents; and milk has been shown to have some negative effects on cells and on the formation of PDL tissue .…”