Milk and Dairy Product Consumption and Bladder Cancer Risk: A Systematic Review and Meta-Analysis of Observational Studies

Bermejo, Laura M.; López-Plaza, Bricia; Santurino, Cristina; Cavero‐Redondo, Iván; Gómez-Candela, Carmen

doi:10.1093/advances/nmy119

Cited by 46 publications

(38 citation statements)

References 65 publications

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“…BCAC Breast Cancer Association Consortium, CI confidence interval, OR odds ratio, PRACTICAL Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome consortium a lower risk of bladder and breast cancer or with a higher risk of prostate cancer, though a positive association between genetically predicted milk consumption and prostate cancer was found in the FinnGen consortium. For bladder cancer, observational studies have reported a protective association mainly with the consumption of fermented milk products (cultured milk, yogurt, and cheese) [12,30]. The lactase persistence variant is not associated with yogurt and cheese consumption [20,21].…”

Section: Discussionmentioning

confidence: 99%

Genetically proxied milk consumption and risk of colorectal, bladder, breast, and prostate cancer: a two-sample Mendelian randomization study

Larsson

Mason

Kar

et al. 2020

BMC Med

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Background Observational studies have shown that milk consumption is inversely associated with colorectal, bladder, and breast cancer risk, but positively associated with prostate cancer. However, whether the associations reflect causality remains debatable. We investigated the potential causal associations of milk consumption with the risk of colorectal, bladder, breast, and prostate cancer using a genetic variant near the LCT gene as proxy for milk consumption. Methods We obtained genetic association estimates for cancer from the UK Biobank (n = 367,643 women and men), FinnGen consortium (n = 135,638 women and men), Breast Cancer Association Consortium (n = 228,951 women), and Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome consortium (n = 140,254 men). Milk consumption was proxied by a genetic variant (rs4988235 or rs182549) upstream of the gene encoding lactase, which catalyzes the breakdown of lactose. Results Genetically proxied milk consumption was associated with a reduced risk of colorectal cancer. The odds ratio (OR) for each additional milk intake increasing allele was 0.95 (95% confidence interval [CI] 0.91–0.99; P = 0.009). There was no overall association of genetically predicted milk consumption with bladder (OR 0.99; 95% CI 0.94–1.05; P = 0.836), breast (OR 1.01; 95% CI 1.00–1.02; P = 0.113), and prostate cancer (OR 1.01; 95% CI 0.99–1.02; P = 0.389), but a positive association with prostate cancer was observed in the FinnGen consortium (OR 1.07; 95% CI 1.01–1.13; P = 0.026). Conclusions Our findings strengthen the evidence for a protective role of milk consumption on colorectal cancer risk. There was no or limited evidence that milk consumption affects the risk of bladder, breast, and prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Genetically proxied milk consumption and risk of colorectal, bladder, breast, and prostate cancer: a two-sample Mendelian randomization study

Larsson

Mason

Kar

et al. 2020

BMC Med

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“…The meta-analysis from Bermejo et al (36) pooled the results of 26 cohort and case-control studies to determine the association between milk and dairy products and bladder cancer. Overall, medium compared with low consumption of total dairy products, milk, and fermented dairy products was significantly associated with lower pooled risk for bladder cancer.…”

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confidence: 99%

Introduction and Executive Summary of the Supplement, Role of Milk and Dairy Products in Health and Prevention of Noncommunicable Chronic Diseases: A Series of Systematic Reviews

Gil

Ortega

2019

Advances in Nutrition

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Milk and dairy products contain multiple nutrients and contribute significantly to meet the nutritional requirements for protein, calcium, magnesium, phosphorus, potassium, zinc, selenium, vitamin A, riboflavin, vitamin B-12, and pantothenic acid. However, consumption of dairy is decreasing and moving away from the advised level in many countries and the potential benefits of milk and dairy products for health have come under question. This, in spite that numerous studies report health benefits associated with dairy consumption. The present supplement aims to assess and summarize scientific evidence regarding the impact of dairy intake on health and all-cause mortality, and on the prevention of diverse chronic diseases, mainly from meta-analyses of observational studies and randomized controlled trials (RCTs). There seem to positive associations between moderate maternal milk intake during pregnancy and infant birth weight, length and bone mineral content during childhood. Moreover, consumption of dairy products in older subjects may reduce the risk of frailty and decrease the risk for sarcopenia. The highest consumption of dairy products did not show a clear association with total osteoporotic fracture and hip fracture risk; however, a diminished risk of vertebral fracture was found. Analysis of the differences between high and low dairy consumption and for dose-response found no association between dairy product consumption and risk of all-cause mortality. Total and low-fat dairy consumption is associated with a reduced risk of developing metabolic syndrome and current evidence supports that consumption of dairy does not adversely affect the risk of cardiovascular outcomes and may even have a subtle protective effect. Moreover, evidence has been provided of an inverse association between the consumption of dairy products and ischemic heart disease and myocardial infarction. Also, the evidence suggests that dairy consumption, particularly low-fat dairy and yogurt is associated with a lower risk of type 2 diabetes. Likewise, moderate compared with medium consumption of dairy is associated lower risk for colorectal and bladder cancer and has no association with prostate cancer. Finally, consumption of milk or dairy products did not show a proinflammatory effect on healthy subjects, overweight/obese individuals, or individuals with other metabolic abnormalities, and fortification of dairy products with phytosterols and ω-3 fatty acids seems to be a good approach to improve cardiometabolic risk biomarkers. In conclusion, the systematic reviews and meta-analyses of the present supplement support adequate milk consumption at various stages of life and in the prevention/control of various noncommunicable chronic diseases.

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“…An updated WCRF-AICR Continuous Update Project in 2017 indicated that colorectal cancer risk decreased by 13% for each 400 g/day increment of dairy product consumption (95% CI: 10-17%) (17). Similarly, four recent meta-analyses (8,11,18,19) reported an inverse association between intake of dairy products, especially fermented dairy foods and bladder cancer risk. These associations may differ by geographical region.…”

Section: Discussionmentioning

confidence: 99%

“…However, the two prospective studies ( 9 , 10 ) included in this meta-analysis have reported inconsistent results. Another meta-analysis by Bermejo et al ( 11 ) also indicated a reduced risk of bladder cancer associated with medium consumption of total dairy products and with medium and high consumption of milk and fermented dairy products. However, a pooled analysis of 13 cohort studies by Acham et al ( 12 ) failed to find a significant association between total or individual dairy products and bladder cancer risk.…”

Section: Introductionmentioning

confidence: 93%

Dairy Product Consumption and Bladder Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cohort

2020

Front. Nutr.

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Evidence has suggested that dairy product consumption lowers the risk of several cancers, but these benefits may not occur with bladder cancer. In a cohort of 101,721 subjects in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, we analyzed the effects of dairy product intake on bladder cancer risk using Cox proportional hazards regression. After a median of 12.5 years of follow-up, 776 new cases of bladder cancer were identified. We found no statistically significant association between total milk intake and bladder cancer risk. The multivariate-adjusted hazard ratio (HR) of bladder cancer for participants in the highest category of total milk intake compared with those in the lowest category was 1.13 (95% CI: 0.92-1.40; p for trend = 0.436). Among individual dairy foods, no statistically significant association was observed for a broad range of dairy products, including whole milk, 2% milk, 1% milk, skim milk, yogurt, regular butter, low fat butter, regular cheese, low fat cheese, and no fat cheese. These associations were not modified by smoking status (p for interaction > 0.05). In conclusion, findings from this large prospective analysis do not support an inverse association between dairy product consumption and bladder cancer risk.

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Milk and Dairy Product Consumption and Bladder Cancer Risk: A Systematic Review and Meta-Analysis of Observational Studies

Cited by 46 publications

References 65 publications

Genetically proxied milk consumption and risk of colorectal, bladder, breast, and prostate cancer: a two-sample Mendelian randomization study

Genetically proxied milk consumption and risk of colorectal, bladder, breast, and prostate cancer: a two-sample Mendelian randomization study

Introduction and Executive Summary of the Supplement, Role of Milk and Dairy Products in Health and Prevention of Noncommunicable Chronic Diseases: A Series of Systematic Reviews

Dairy Product Consumption and Bladder Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cohort

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