2023
DOI: 10.1111/nmo.14696
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Milk coagulation and gastric emptying in women experiencing gastrointestinal symptoms after ingestion of cow's milk

Elise J. M. van Eijnatten,
Guido Camps,
Mathilde Guerville
et al.

Abstract: BackgroundGastrointestinal symptoms after drinking milk are often attributed to lactose intolerance or cow's milk allergy. However, some individuals without either condition still report gastrointestinal symptoms after drinking milk. This may be caused by gastric emptying (GE) rate or gastric protein coagulation. This study aimed to compare GE rate and protein coagulation after milk consumption between individuals reporting gastrointestinal symptoms and those without symptoms using a novel gastric MRI approach… Show more

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Cited by 9 publications
(4 citation statements)
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“…Subsequently, a weighted average texture metric was calculated based on the gastric content volume in each slice such that slices with little stomach content contributed less to the average than those with more stomach content. To quantify the (relative) volume of liquid and semi-solid stomach contents the number of lighter (more liquid), intermediate and darker (semi-solid) voxels was calculated by determining two intensity thresholds with the use of Otsu’s method (Otsu 1979) in Matlab (version R2023a, multitresh function), an approach previously used on in vitro and in vivo MRI images of gastric milk digestion (Mayar, Smeets et al 2023, van Eijnatten, Camps et al 2023, Mayar, de Vries et al 2024). The number of intermediate and darker voxels were summed and interpreted as reflecting voxels in which coagulation took place.…”
Section: Methodsmentioning
confidence: 99%
“…Subsequently, a weighted average texture metric was calculated based on the gastric content volume in each slice such that slices with little stomach content contributed less to the average than those with more stomach content. To quantify the (relative) volume of liquid and semi-solid stomach contents the number of lighter (more liquid), intermediate and darker (semi-solid) voxels was calculated by determining two intensity thresholds with the use of Otsu’s method (Otsu 1979) in Matlab (version R2023a, multitresh function), an approach previously used on in vitro and in vivo MRI images of gastric milk digestion (Mayar, Smeets et al 2023, van Eijnatten, Camps et al 2023, Mayar, de Vries et al 2024). The number of intermediate and darker voxels were summed and interpreted as reflecting voxels in which coagulation took place.…”
Section: Methodsmentioning
confidence: 99%
“…This study involves two cohorts of subjects, one from Italy and one from The Netherlands, who participated in two studies that were conducted at the same time and shared the same criteria (except sex) for the selection of subjects aiming at exploring the physiological mechanisms underpinning cow’s milk digestion by focusing on post-prandial gastro-intestinal responses or gastric emptying, respectively [ 24 , 25 ]. In the present study, the combination of data on diets and gut microbiome collected over the two main studies was performed to increase the sample size and statistical power.…”
Section: Methodsmentioning
confidence: 99%
“…The trials were registered at www.clinicaltrials.gov (number NCT04205045) and Dutch Trial Register (number NTR7531) for Italian and Dutch cohort, respectively. The two cohorts included healthy, adult subjects, without food allergy/intolerance, and having an omnivorous diet [ 24 , 25 ]. The Italian cohort included males and females whereas the Dutch cohort was of only females.…”
Section: Methodsmentioning
confidence: 99%
“…A recent study assessed gastric milk coagulation in women experiencing gastro-intestinal (GI) complaints and in a control group after milk consumption by calculating image texture metrics, namely homogeneity, contrast, busyness, and coarseness, for the ܶ ଶ -weighted anatomical images (van Eijnatten et al, 2023). The decrease in homogeneity, and increase in contrast and coarseness, were associated with the coagulation process.…”
Section: Interpretation Of Mt Mri Datamentioning
confidence: 99%