Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults

V. Calvo, María; Loria Kohen, Viviana; Díaz-Mardomingo, Carmen; García-Herranz, Sara; Baliyan, Shishir; Tomé-Carneiro, João; Colmenarejo, Gonzalo; Visioli, Francesco; Venero, César; Fontecha, Javier

doi:10.1016/j.jff.2023.105849

Cited by 11 publications

(3 citation statements)

References 69 publications

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“…In adults aged 65 years and older with a mild age-related cognitive impairment, supplementation of MFGMs as a fortified milk drink improved short-term memory, specifically episodic memory or the ability to recall recent events in female participants [ 127 ]. Loneliness, anxiety, and late-life depression are acutely associated with a perceived decline in cognitive function [ 128 , 129 ].…”

Section: Mfgm and Mental Health In Older Adultsmentioning

confidence: 99%

Milk Fat Globule Membranes for Mental Health across the Human Lifespan

Slykerman,

Davies,

Fuad

et al. 2024

Foods

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The milk fat globule membrane (MFGM) contains bioactive proteins, carbohydrates, and lipids. Polar lipids found in the MFGM play a critical role in maintaining cell membrane integrity and neuronal signalling capacity, thereby supporting brain health. This review summarises the literature on the MFGM and its phospholipid constituents for improvement of mental health across three key stages of the human lifespan, i.e., infancy, adulthood, and older age. MFGM supplementation may improve mental health by reducing neuroinflammation and supporting neurotransmitter synthesis through the gut–brain axis. Fortification of infant formula with MFGMs is designed to mimic the composition of breastmilk and optimise early gut and central nervous system development. Early behavioural and emotional development sets the stage for future mental health. In adults, promising results suggest that MFGMs can reduce the negative consequences of situational stress. Preclinical models of age-related cognitive decline suggest a role for the MFGM in supporting brain health in older age and reducing depressive symptoms. While there is preclinical and clinical evidence to support the use of MFGM supplementation for improved mental health, human studies with mental health as the primary target outcome are sparce. Further high-quality clinical trials examining the potential of the MFGM for psychological health improvement are important.

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Section: Mfgm and Mental Health In Older Adultsmentioning

confidence: 99%

Milk Fat Globule Membranes for Mental Health across the Human Lifespan

Slykerman,

Davies,

Fuad

et al. 2024

Foods

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“…PL can be categorized into five main types: phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), and sphingomyelin (SM) . PL not only acts as emulsifiers to maintain stability of milk fat/water emulsion system but also have multiple unique physiological functions, including increased anti-inflammatory activity and reduced risk of cardiovascular disease. , Dietary sphingolipids have been shown to increase the cognitive behavior and episodic memory of infants. − …”

Section: Introductionmentioning

confidence: 99%

Lipidomic Comparisons of Whole Cream Buttermilk Whey and Cheese Whey Cream Buttermilk of Caprine Milk

Song,

Liu,

et al. 2024

J. Agric. Food Chem.

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Buttermilk is a potential material for the production of a milk fat globule membrane (MFGM) and can be mainly classified into two types: whole cream buttermilk and cheese whey cream buttermilk (WCB). Due to the high casein micelle content of whole cream buttermilk, the removal of casein micelles to improve the purity of MFGM materials is always required. This study investigated the effects of rennet and acid coagulation on the lipid profile of buttermilk rennet-coagulated whey (BRW) and buttermilk acid-coagulated whey (BAW) and compared them with WCB. BRW has significantly higher phospholipids (PLs) and ganglioside contents than BAW and WCB. The abundance of arachidonic acid (ARA)-and eicosapentaenoic acid (EPA)-structured PLs was higher in WCB, while docosahexaenoic acid (DHA)-structured PLs were higher in BRW, indicating that BRW and WCB intake might have a greater effect on improving cardiovascular conditions and neurodevelopment. WCB and BRW had a higher abundance of plasmanyl PL and plasmalogen PL, respectively. Phosphatidylcholine (PC) (28:1), LPE (20:5), and PC (26:0) are characteristic lipids among BRW, BAW, and WCB, and they can be used to distinguish MFGM-enriched whey from different sources.

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“…MFGM is recognized for its potential health benefits, especially in infants, as it promotes, for example, the maturation of the gut and the immune system, as well as boosts the cognitive development [5,6]. Studies conducted on older subjects have found that MFGM-enriched milk improves episodic memory [7], while MFGM supplementation combined with exercise may be beneficial in improving walking speed and other walking parameters, such as step length [8].…”

Section: Introductionmentioning

confidence: 99%

Milk Fat Globule Membrane-Containing Protein Powder Promotes Fitness inCaenorhabditis elegans

Pitkänen,

Matilainen

2024

Preprint

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Milk-derived peptides and milk fat globule membrane (MFGM) have gained interest as health-promoting food ingredients. However, the mechanisms by which these nutraceuticals modulate the function of biological systems often remain unclear. We utilizedCaenorhabditis elegansto elucidate how milk-derived Protein powders rich in MFGM, previously used in a clinical trial, affect the physiology of this model organism. Our results demonstrate that Protein powders do not affect lifespan but promote the fitness of the animals. Surprisingly, gene expression analysis revealed that Protein powders decrease the expression of genes functioning on innate immunity, which also translates into reduced survival on pathogenic bacteria. One of the innate immunity-associated genes showing reduced expression upon Protein powder supplementation iscpr-3, the homolog of human cathepsin B. Interestingly, knockdown ofcpr-3enhances fitness, but not in Protein powder-treated animals, suggesting that protein powders contribute to fitness by downregulating the expression of this gene. In summary, this research highlights the value ofC. elegansin testing the biological activity of food supplements and nutraceuticals. Furthermore, this study should encourage investigations into whether milk-derived peptides and MFGM mediate their beneficial effects through the modulation of cathepsin B expression in humans.

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Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults

Cited by 11 publications

References 69 publications

Milk Fat Globule Membranes for Mental Health across the Human Lifespan

Milk Fat Globule Membranes for Mental Health across the Human Lifespan

Lipidomic Comparisons of Whole Cream Buttermilk Whey and Cheese Whey Cream Buttermilk of Caprine Milk

Milk Fat Globule Membrane-Containing Protein Powder Promotes Fitness inCaenorhabditis elegans

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