This study was aimed to investigate the effect of heat stress and seasons on diurnal body temperature, milk yield, and physicochemical properties of dromedary camel in southeastern rangelands Ethiopia. Twenty lactating camels with 2-3 months postmortem and 3-4 parities were selected for evaluation of milk yield, physicochemical properties, and body temperature measurements. The current finding shows diurnal body temperature was significantly higher in hot weather conditions (dry season). Temperature-humidity index (THImax) showed a strong positive correlation to rectal body temperatures (r = 0.72) and daily milk yield (r = 0.6) of a camel. The mean daily milk yield observed in this study was 6.02, 4.99, 2.38, and 2.57 Liters (L) during autumn, spring, summer, and winter, respectively, and showed higher (P < 0.001) milk yield in rainy season. Mean percentage of protein (3.1%), casein (1.9%), lactose (4.9%), solid-not-fat (SNF) (8.53%), and total solids (TS) (12.7%) was greater (P < 0.001) in wet season. Milk fat and energy-Matiwos Habte ABOUT THE AUTHOR Matiwos Habte is an academic staff of Dilla University. He is a PhD candidate of Climate Smart Agriculture and Biodiversity Conservation in the Africa Center of Excellence for Climate Smart Agriculture and Biodiversity Conservation at Haramaya University. He has several publications on livestock production. Dr Mitiku Eshetu is an academic staff of the Haramaya University. He has demonstrated high expertise and interest in dairy science with a bias for camel production. Dr Abiyot Legesse is an academic staff of Dilla University. He has demonstrated high interest in climate and land use/land cover change-related impacts on food security. Dr Dereje Andualem is an academic staff of Dilla University. He has demonstrated his expertise in the impacts of microclimatic condition on livestock production for food security. Dr Melesse Maryo is a National Director of the Ethiopian biodiversity institute. He has demonstrated a high interest in biodiversity conservation and climate-smart agriculture and food security.