Milky Sap of Greater Celandine (Chelidonium majus L.) and Anti-Viral Properties

Nawrot, Joanna; Wilk-Jędrusik, Małgorzata; Nawrot, Sylwia; Nawrot, Krzysztof; Wilk, Barbara K.; Dawid-Pać, Renata; Urbańska, Maria; Micek, Iwona; Nowak, Gerard; Gornowicz‐Porowska, Justyna

doi:10.3390/ijerph17051540

Cited by 19 publications

(20 citation statements)

References 20 publications

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“…We present the comparison with scientific literature (for the complete data, please see Table S1 ): Achillea millefolium digestive, anti-inflammatory for several problems (stomachache, muscular pain, rash) and disinfectant [ 19 , 23 , 24 , 25 ]; Achillea moschata antioxidant and antibacterial [ 26 ]; Alchemilla vulgaris anti-inflammatory [ 27 , 28 ]; Arnica montana anti-inflammatory for wounds, cutaneous traumas, muscular, and articular pain [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]; Artemisia absinthium digestive [ 31 , 37 , 38 , 39 ] (however, in a review from 2016 the potential antiulcer effect, with the decrease in the production of gastric juice, is reported [ 40 ]); Artemisia genipi digestive and colds [ 39 , 41 ]; Betula pendula diuretic [ 42 ]; Calendula officinalis anti-inflammatory and disinfectant for wounds, rashes, and burns, improves circulation [ 31 , 43 , 44 , 45 , 46 , 47 , 48 ]; Carduus nutans antimicrobial and anti-inflammatory [ 49 ]; Cetraria islandica expectorant [ 50 , 51 , 52 ] and anti-inflammatory [ 51 , 53 ]; Chelidonium majus skin tags and warts [ 54 , 55 ]; Cichorium intybus depurative of the urinary tract […”

Section: Resultsmentioning

confidence: 99%

“…We focused our attention particularly on systematic reviews and meta-analysis, when possible, or on single in vitro, in vivo, and clinical trials studies, applying no time filters. Based on this data, specific and detailed tables were produced ( Table 4 and Supplementary Materials Table S1 [ 2 , 3 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , ...…”

Section: Methodsmentioning

confidence: 99%

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Using Medicinal Plants in Valmalenco (Italian Alps): From Tradition to Scientific Approaches

et al. 2020

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This ethnobotanical survey was carried out in Caspoggio (Valmalenco, SO, Italy) with the purpose of investigating the traditional uses of medicinal plants. Moreover, a bibliographic research meant to validate or refute the uses, focusing on the potentially responsible compounds, was performed. Fifty-nine species, attributable to 30 families (Asteraceae, Pinaceae, Malvaceae, and Lamiaceae the most cited), were mentioned. Arnica montana, anti-inflammatory for traumas and musculoskeletal pains; Pinus mugo, expectorant; Malva sylvestris, anti-inflammatory and soothing; Achillea moschata, digestive. The compounds, responsible for the therapeutic activities, are often polyphenols and terpenoids: helenanin in A. montana, α-pinene, δ-3-carene, and limonene in P. mugo, gossypin and malvin in M. sylvestris, luteolin and apigenin in A. moschata. Scientific evidence for at least one of the traditional activities described was found for 50 species but only in 26 out of 196 works consulted, it is possible to make a comparison between investigated extracts and traditional preparations. This study is thus a stimulus to new phytochemical investigations, mimicking as much as possible the traditional preparations. This work is part of the European Interreg Italy-Switzerland B-ICE project, aimed at creating a management model for the ongoing climate change and searching for new sources of territory valorization as attractions for tourists.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Using Medicinal Plants in Valmalenco (Italian Alps): From Tradition to Scientific Approaches

et al. 2020

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“…The antiviral effect of Chelidonium majus has been reported in previous in vitro and in vivo studies (Gerencer et al, 2006;Lozjuk et al, 1996;Nawrot et al, 2020). Such inhibitory activity against papillomavirus, adenovirus, herpesvirus, and poliovirus is majorly attributed to its alkaloids.…”

Section: Discussionmentioning

confidence: 75%

“…More recently, its in vitro and in vivo antiviral activity has been studied (Gerencer et al, 2006; Lozjuk, Lisnyak, & Lozjuk, 1996; Nawrot et al, 2020), a fact that encouraged the authors to use greater celandine for patients with COVID‐19.…”

Section: Introductionmentioning

confidence: 99%

Greater celandine (Chelidonium majus L.) for COVID‐19: A twenty‐case series

Gardin¹,

Braga²

2021

Phytotherapy Research

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Wuhan, China, with a rapid increase in cases worldwide. Until now, among several drugs tested, none demonstrated sufficient efficacy for its etiological treatment.Greater celandine (Chelidonium majus L.) is a well-known medicinal plant, traditionally indicated for digestive disorders and topically to remove warts. This study, performed at private offices in São Paulo and Aracaju (Brazil), describes 20 consecutive COVID-19 outpatients treated with greater celandine and their clinical evolution. The patients, aged 14-71 years (median of 41 years), were treated with Chelidonium majus 10% mother tincture, 20-30 drops three times a day for 3-12 days (median of 5 days). Clinical features were assessed during the treatment and at least until 1 week after its end. These cases were considered mild, as most COVID-19 cases.The symptoms were mainly fever, fatigue, cough, sore throat, coryza, anosmia, ageusia, and headache. Ten patients had comorbidities, such as hypertension, diabetes, and overweight. Complete or almost complete clinical improvement occurred within 1-9 days of treatment (median of 3 days). There were no adverse events. This casuistry, although small, may inspire other researchers to continue investigating Chelidonium majus as a healing treatment for COVID-19.

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“…26 Though warts are the external manifestations, they represent the internal derangement and play an important role in distinguishing between different cases of disease and thus the appropriate remedy. 26 There are studies [28][29][30] exploring the effects of various homeopathic medicines in warts. Successful treatment and complete remission of warts with homeopathic medicines have been documented in observational studies, 31,32 a case series, 33 and case reports.…”

Section: Introductionmentioning

confidence: 99%

A Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Individualized Homeopathic Medicines for Cutaneous Warts

Dey¹,

Hashmi

Saha

et al. 2021

Homeopathy

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Background Though frequently used in practice, research studies have shown inconclusive benefits of homeopathy in the treatment of warts. We aimed to assess the feasibility of a future definitive trial, with preliminary assessment of differences between effects of individualized homeopathic (IH) medicines and placebos in treatment of cutaneous warts. Methods A double-blind, randomized, placebo-controlled trial (n = 60) was conducted at the dermatology outpatient department of D.N. De Homoeopathic Medical College and Hospital, West Bengal. Patients were randomized to receive either IH (n = 30) or identical-looking placebo (n = 30). Primary outcome measures were numbers and sizes of the warts; secondary outcome was the Dermatology Life Quality Index (DLQI) questionnaire measured at baseline, and every month up to 3 months. Group differences and effect sizes were calculated on the intention-to-treat sample. Results Attrition rate was 11.6% (IH, 3; placebo, 4). Intra-group changes were significantly greater (all p < 0.05, Friedman tests) in IH than placebo. Inter-group differences were statistically non-significant (all p > 0.05, Mann-Whitney U tests) with small effect sizes—both in the primary outcomes (number of warts after 3 months: IH median [inter-quartile range; IQR] 1 [1, 3] vs. placebo 1 [1, 2]; p = 0.741; size of warts after 3 months: IH 5.6 mm [2.6, 40.2] vs. placebo 6.3 [0.8, 16.7]; p = 0.515) and in the secondary outcomes (DLQI total after 3 months: IH 4.5 [2, 6.2] vs. placebo 4.5 [2.5, 8]; p = 0.935). Thuja occidentalis (28.3%), Natrum muriaticum (10%) and Sulphur (8.3%) were the most frequently prescribed medicines. No harms, homeopathic aggravations, or serious adverse events were reported. Conclusion As regards efficacy, the preliminary study was inconclusive, with a statistically non-significant direction of effect favoring homeopathy. The trial succeeded in showing that an adequately powered definitive trial is both feasible and warranted. Trial Registration CTRI/2019/10/021659; UTN: U1111–1241–7340

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Milky Sap of Greater Celandine (Chelidonium majus L.) and Anti-Viral Properties

Cited by 19 publications

References 20 publications

Using Medicinal Plants in Valmalenco (Italian Alps): From Tradition to Scientific Approaches

Using Medicinal Plants in Valmalenco (Italian Alps): From Tradition to Scientific Approaches

Greater celandine (Chelidonium majus L.) for COVID‐19: A twenty‐case series

A Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Individualized Homeopathic Medicines for Cutaneous Warts

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