Miller Fischer syndrome after COVID-19 infection and vaccine: a systematic review

Neophytou, Panayiota; Artemiadis, Artemios; Hadjigeorgiou, Georgios M.; Zis, Panagiotis

doi:10.1007/s13760-023-02336-5

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…Searching for previously reported relevant scientific articles and literature found no cases of MFS associated with SARS cov-2 in the Republic of Kazakhstan. However, there was only one case of MFS has been described in the Russian Federation [8,9]. Researchers who conducted genetic analyses of COVID-19 recovered patients discovered that Asians and individuals of African descent experienced more severe outcomes.…”

Section: Discussionmentioning

confidence: 99%

A rare neurological complication of COVID-19: Pediatric Miller Fisher Syndrome. A case report

Mukhaliyev,

Rahmatulla,

Mayufi

et al. 2023

J CLIN MED KAZ

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The SARS-CoV-2 pandemic has significantly transformed the world. While it was initially viewed as a respiratory virus, it has now been found to cause cardiovascular, gastrointestinal, and psychological complications. Moreover, the nervous system (NS) is also greatly affected. Research has identified dizziness, headaches, as well as disturbances in one's taste and smell abilities as the most frequent symptoms of NS involvement. Even more significant changes may occur in patients who get infected with SARS CoV-2, such as the development of acute cerebrovascular disorders (stroke), multiple sclerosis, acute disseminated encephalitis, Guillain-Barré syndrome, encephalitis, and myelitis. It is important to note these potential complications and monitor patients closely. A retrospective study conducted in Wuhan, China revealed that CNS (central nervous system) involvement occurred three times more frequently than PNS (peripheral nervous system) involvement. This emphasizes the critical importance of studying and describing CNS manifestations. This case report depicts Miller Fisher syndrome in a 5-month-old infant after SARS CoV-2 infection and explores literature on pediatric cases and potential pathogenic mechanisms.

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Section: Discussionmentioning

confidence: 99%

A rare neurological complication of COVID-19: Pediatric Miller Fisher Syndrome. A case report

Mukhaliyev,

Rahmatulla,

Mayufi

et al. 2023

J CLIN MED KAZ

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“…Although a rare occurrence, multiple cases of MFS following COVID-19 vaccination have been described across several countries ( 48 – 50 ). Unlike GBS associated with vaccination, it does not appear to be related to the viral vector vaccination ( 51 ).…”

Section: Pathogenesismentioning

confidence: 99%

Miller Fisher syndrome: an updated narrative review

Noioso,

Bevilacqua,

Acerra

et al. 2023

Front. Neurol.

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IntroductionMiller Fisher syndrome (MFS) is considered a rare variant of Guillain-Barré syndrome (GBS), a group of acute-onset immune-mediated neuropathies characterized by the classic triad of ataxia, areflexia, and ophthalmoparesis. The present review aimed to provide a detailed and updated profile of all aspects of the syndrome through a collection of published articles on the subject, ranging from the initial description to recent developments related to COVID-19.MethodsWe searched PubMed, Scopus, EMBASE, and Web of Science databases and gray literature, including references from the identified studies, review studies, and conference abstracts on this topic. We used all MeSH terms pertaining to “Miller Fisher syndrome,” “Miller Fisher,” “Fisher syndrome,” and “anti-GQ1b antibody.”ResultsAn extensive bibliography was researched and summarized in the review from an initial profile of MFS since its description to the recent accounts of diagnosis in COVID-19 patients. MFS is an immune-mediated disease with onset most frequently following infection. Anti-ganglioside GQ1b antibodies, detected in ~85% of patients, play a role in the pathogenesis of the syndrome. There are usually no abnormalities in MFS through routine neuroimaging. In rare cases, neuroimaging shows nerve root enhancement and signs of the involvement of the central nervous system. The most consistent electrophysiological findings in MFS are reduced sensory nerve action potentials and absent H reflexes. Although MFS is generally self-limited and has excellent prognosis, rare recurrent forms have been documented.ConclusionThis article gives an updated narrative review of MFS with special emphasis on clinical characteristics, neurophysiology, treatment, and prognosis of MFS patients.

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“…Reyes-Bueno et al detailed the post-COVID-19 Miller Fisher syndrome (MFS) reported in some patients which included complaints of blurred vision and extra-ocular muscle palsy [ 55 ]. Neophytou et al published a systematic review of this syndrome in COVID-19 patients with a conclusion that the condition occurred more frequently after infection as compared to after vaccination [ 56 ]. The prognosis of MFS is spontaneous and very good even without administering intravenous immunoglobulin [ 56 ].…”

Section: Ocular Manifestations Of Covid-19mentioning

confidence: 99%

“…Neophytou et al published a systematic review of this syndrome in COVID-19 patients with a conclusion that the condition occurred more frequently after infection as compared to after vaccination [ 56 ]. The prognosis of MFS is spontaneous and very good even without administering intravenous immunoglobulin [ 56 ].…”

Section: Ocular Manifestations Of Covid-19mentioning

confidence: 99%

Considerations of COVID-19 in Ophthalmology

Salvetat,

Musa,

Pellegrini

et al. 2023

Microorganisms

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Since its emergence in early 2020, the SARS-CoV-2 infection has had a significant impact on the entire eye care system. Ophthalmologists have been categorized as a high-risk group for contracting the virus due to the belief that the eye may be a site of inoculation and transmission of the SARS-CoV-2 infection. As a result, clinical ophthalmologists, optometrists, and eyecare professionals have had to familiarize themselves with the ocular manifestations of COVID-19, as well as its treatments and vaccines. The implementation of measures to prevent the transmission of the virus, such as restrictions, lockdowns, telemedicine, and artificial intelligence (AI), have led to substantial and potentially irreversible changes in routine clinical practice, education, and research. This has resulted in the emergence of a new mode of managing patients in a routine clinical setting. This brief review aims to provide an overview of various aspects of COVID-19 in ophthalmology, including the ocular manifestations related to the disease, the modes of transmission of SARS-CoV-2 infection, precautions taken in ophthalmic practice to prevent the spread of the virus, drugs, and vaccines used in the treatment of COVID-19, the impact of the pandemic on patients, clinicians, and the eye care system as a whole, and the future of ophthalmology conditioned by this global pandemic experience.

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Miller Fischer syndrome after COVID-19 infection and vaccine: a systematic review

Cited by 4 publications

References 37 publications

A rare neurological complication of COVID-19: Pediatric Miller Fisher Syndrome. A case report

A rare neurological complication of COVID-19: Pediatric Miller Fisher Syndrome. A case report

Miller Fisher syndrome: an updated narrative review

Considerations of COVID-19 in Ophthalmology

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