Millettia ferruginea extract attenuates cisplatin-induced alterations in kidney functioning, DNA damage, oxidative stress, and renal tissue morphology

Yassir, Mouna; Tir, Meriam; Mufti, Afoua; Feriani, Anouar; Faidi, Bilel; Tlili, Nizar; Sobeh, Mansour

doi:10.1016/j.arabjc.2022.104037

Cited by 7 publications

(9 citation statements)

References 39 publications

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“…The current study revealed that the administration of cisplatin elicited an accumulation of various reactive oxygen species (ROS), resulting in depleting the antioxidant system and activating the antioxidant enzymes. As evidenced by our findings, catalase (CAT) and superoxide dismutase (SOD) activities were found to be reduced in rats treated with cisplatin, alongside a decrease in glutathione (GSH) levels when compared to the control groups; this finding aligns with previous reports (Yassir et al, 2022;Anwer et al, 2023). Furthermore, an elevation in MDA levels was observed, indicating an augmentation in lipid peroxidation.…”

Section: Discussionsupporting

confidence: 93%

“…The administration of cisplatin leads to an upregulation of renal biomarkers, namely, creatinine, uric acid and urea which indicates potential kidney damage. A similar effect was reported earlier, which revealed a significant increase in these parameters ( Yassir et al, 2022 ).…”

Section: Discussionsupporting

confidence: 91%

“…Cisplatin, also known as cis-dichlorodiammine platinum (II), is one of the most potent chemotherapeutic drugs used in the treatment of cancer. However, nephrotoxicity, myelosuppression, hypersensitive responses, ototoxicity, neurotoxicity, and bone marrow suppression have limited its application ( Yassir et al, 2022 ). The hallmark of cisplatin nephrotoxicity is the significant death of renal proximal tubular (RPT) cells, by both necrosis and apoptosis ( Cao et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, it is essential to develop a medication that is both safe and effective for preventing kidney damage caused by cisplatin. A large number of naturally occurring compounds found in plants possess antioxidant and anti-inflammatory properties, which can provide a wide range of health benefits, including protection against oxidative stress by restoring the antioxidant enzymes levels, this refers to a strategy that holds significant interest for chemotherapy ( Fang et al, 2021 ; Yassir et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Leonotis ocymifolia (Burm.f.) Iwarsson aerial parts aqueous extract mitigates cisplatin-induced nephrotoxicity via attenuation of inflammation, and DNA damage

et al. 2023

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Herein, we explored the protective effect of Leonotis ocymifolia (Burm.f.) Iwarsson aerial parts extract (LO) against cisplatin (CP)-induced nephrotoxicity in rats and profiled their phytocontents. A total of 31 compounds belonging to organic and phenolic acids and their glycosides as well as flavonoids and their O- and C-glycosides were identified through LC-MS/MS. The DPPH and FRAP assays revealed that the extract had powerful antioxidant properties. The in vivo results demonstrated that administering LO extract for 30 days (40 and 80 mg/kg b. w.) significantly improved the altered renal injury markers via reducing creatinine (high dose only) and uric acid levels compared to the Cp-group. The deleterious action of cisplatin on renal oxidative stress markers (GSH, MDA, SOD, and CAT) were also mitigated by LO-pretreatment. The reduction of the inflammatory marker (IL-6), and inhibition of DNA fragmentation, highlighted the prophylactic action of LO in kidney tissue. Molecular docking followed by a 100 ns molecular dynamic simulation analyses revealed that, amongst the 31 identified compounds in LO, chlorogenic and caffeoylmalic acids had the most stable binding to IL-6. The nephroprotective effects were further confirmed by histopathological observations, which showed improvement in ultrastructural changes induced by cisplatin. The observed findings reinforce the conclusion that L. ocymifolia extract exerts nephroprotective properties, which could be related to its antioxidant and anti-inflammatory activities. Further studies are required to determine the therapeutic doses and the proper administration time.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Leonotis ocymifolia (Burm.f.) Iwarsson aerial parts aqueous extract mitigates cisplatin-induced nephrotoxicity via attenuation of inflammation, and DNA damage

et al. 2023

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“…Cisplatin as a chemotherapeutic agent frequently used to treat head, neck cancers, tumors of the bladder, ovary, and testis (Yassir et al, 2022). Regrettably, many cancer cells have resisted cisplatin therapy or are on the verge of developing resistance (Luo et al, 2010).…”

Section: Kaempferol's Inhibitory Effects On Chemotherapy Resistancementioning

confidence: 99%

Kaempferol's potential effects againstSARS‐CoV‐2 andCOVID‐19‐associated cancer progression and chemo‐resistance

Zalpoor

Liaghat

Bakhtiyari

et al. 2023

Phytotherapy Research

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Dear Editor, Nowadays, many studies suggest Coronavirus disease-2019 (COVID-19) potentially may contribute to multiple cancers' progression and poor outcomes in cancer treatments. Numerous studies have discussed some potential cellular and molecular mechanisms for the role of SARS-CoV-2 in these complications for cancer patients and related therapeutic approaches (Zalpoor, Akbari, Nayerain Jazi, Liaghat, & Bakhtiyari, 2022;.For instance, multiple signaling pathways and factors stimulated and upregulated by SARS-CoV-2 infection such as activated mammalian target of rapamycin (mTOR), hypoxia-inducible factor-1 alpha (HIF-1α), and increased autophagy (

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Ajwa dates (Phoenix dactylifera L.) attenuate cisplatin-induced nephrotoxicity in rats via augmenting Nrf2, modulating NADPH oxidase-4 and mitigating inflammatory/apoptotic mediators

Abdelghffar

Obaid²,

Saleh³

et al. 2022

Biomedicine & Pharmacotherapy

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Millettia ferruginea extract attenuates cisplatin-induced alterations in kidney functioning, DNA damage, oxidative stress, and renal tissue morphology

Cited by 7 publications

References 39 publications

Leonotis ocymifolia (Burm.f.) Iwarsson aerial parts aqueous extract mitigates cisplatin-induced nephrotoxicity via attenuation of inflammation, and DNA damage

Leonotis ocymifolia (Burm.f.) Iwarsson aerial parts aqueous extract mitigates cisplatin-induced nephrotoxicity via attenuation of inflammation, and DNA damage

Kaempferol's potential effects againstSARS‐CoV‐2 andCOVID‐19‐associated cancer progression and chemo‐resistance

Ajwa dates (Phoenix dactylifera L.) attenuate cisplatin-induced nephrotoxicity in rats via augmenting Nrf2, modulating NADPH oxidase-4 and mitigating inflammatory/apoptotic mediators

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