Millettia macrophylla (Fabaceae) phenolic fraction prevents differentiation of 3T3-L1 adipocytes and the increased risks of cardiovascular diseases in ovariectomized rats

Zingue, Stéphane; Carmo, Ícaro Andrade Rodrigues do; Tchoumtchoua, Job; Tchoupang, Edwige Nana; Bratti, Letícia de Oliveira Souza; Mora, Tamara Dal; Halabalaki, Maria; Njamen, Dieudonné; Creczynski-Pasa, Tânia Beatriz; Filippin-Monteiro, Fabíola Branco

doi:10.1016/j.jep.2018.04.046

Cited by 4 publications

(3 citation statements)

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“…Dandelion leaf and petal phenolic fractions, enriched with l-chicoric acid, are promising plant materials that may exert in vivo beneficial antioxidant effects.Antioxidants 2020, 9, 131 2 of 13 as thrombosis and atherosclerosis. Thus, preparations exerting both antioxidant and anticoagulant activities based on safe natural substances are continuously sought after for their potentially wide range of health benefits in the prevention and treatment of cardiovascular disorders [1][2][3][4][5][6][7].Nowadays, the dandelion (Taraxacum officinale) herb and root are used as a component of food products, dietary supplements and pharmacological preparations for various ailments (mainly liver, gallbladder and kidney disorders) [8,9]. This is due to a wide range of biological activities, including antihyperglycemic, antioxidant and anti-inflammatory actions demonstrated by dandelion fractions and their constituents, with no reported adverse effects, together with a well-understood chemical composition and a widespread occurrence of the plant throughout the world [10,11].…”

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Phenolic Fractions from Dandelion Leaves and Petals as Modulators of the Antioxidant Status and Lipid Profile in an In Vivo Study

et al. 2020

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Alcoholic leaf and petal fractions of Taraxacum officinale (dandelion) were previously demonstrated to exert in vitro antioxidant and antithrombotic activities in blood plasma and platelets. Eight-week-old male Wistar rats (n = 6) were supplemented for four weeks with dandelion fractions (694 mg/kg of diet = 11.9 ± 0.6 mg daily). Dandelion leaf and petal fractions, which delivered daily 4.10 ± 0.05 and 1.41 ± 0.07 mg l-chicoric acid, respectively, were shown to exert antioxidative actions, measured as decreased levels of thiobarbituric acid-reactive substances (TBARS) in the spleen (≈0.8-fold, leaves and petals), brain (0.53-fold, leaves) and thoracic arteries (0.59-fold, petals). Moreover, petal fraction increased thiols in the blood plasma (1.58-fold), while leaf fraction decreased protein carbonylation levels (0.59-fold). Additionally, dandelion leaf fractions modified the lipid profile: decreased triglyceride (0.44-fold), total cholesterol (0.73-fold), lipoprotein combine index (0.32-fold) and the atherogenic index of plasma (0.62-fold). Dandelion fractions showed a beneficial decrease effect in the participation of cyclooxygenase products in the noradrenaline-induced vascular contractions of thoracic arteries. Meanwhile, only the dandelion leaf fraction augmented acetylcholine-induced vasodilation and upregulated K ATP channels. The heart rate and blood pressure were not modified. Dandelion leaf and petal phenolic fractions, enriched with l-chicoric acid, are promising plant materials that may exert in vivo beneficial antioxidant effects.Antioxidants 2020, 9, 131 2 of 13 as thrombosis and atherosclerosis. Thus, preparations exerting both antioxidant and anticoagulant activities based on safe natural substances are continuously sought after for their potentially wide range of health benefits in the prevention and treatment of cardiovascular disorders [1][2][3][4][5][6][7].Nowadays, the dandelion (Taraxacum officinale) herb and root are used as a component of food products, dietary supplements and pharmacological preparations for various ailments (mainly liver, gallbladder and kidney disorders) [8,9]. This is due to a wide range of biological activities, including antihyperglycemic, antioxidant and anti-inflammatory actions demonstrated by dandelion fractions and their constituents, with no reported adverse effects, together with a well-understood chemical composition and a widespread occurrence of the plant throughout the world [10,11]. Aqueous-organic extracts from the dandelion herb were found to exert an anti-inflammatory action [12], mainly due to decreasing the expression of proinflammatory cytokines by inhibiting the nuclear factor (NF)-κB [13], tumor necrosis factor (TNF)-α and interleukin (IL)-1β [14], as well as reducing the expression and production of inducible nitric oxide synthase/nitric oxide (iNOS/NO) and cyclooxygenase (COX)-2/prostaglandin E2 [15].Plant polyphenols have the ability to protect dietary lipids, proteins and vitamins from oxidation. Additionally, they may also provide health bene...

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confidence: 99%

“…Antioxidants 2020, 9, 131 2 of 13 as thrombosis and atherosclerosis. Thus, preparations exerting both antioxidant and anticoagulant activities based on safe natural substances are continuously sought after for their potentially wide range of health benefits in the prevention and treatment of cardiovascular disorders [1][2][3][4][5][6][7].…”

mentioning

confidence: 99%

Phenolic Fractions from Dandelion Leaves and Petals as Modulators of the Antioxidant Status and Lipid Profile in an In Vivo Study

et al. 2020

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“…These basic studies provide evidence for phytoestrogens to prevent lipid metabolism disorders and NAFLD in postmenopausal women. Table 1 lists other studies on phytoestrogens improving lipid metabolism in ovariectomized models (Dai et al, 2004;Böttner et al, 2008;Pakalapati et al, 2009;Miller et al, 2015;Cross et al, 2017;Chen et al, 2018;Zheng et al, 2018;Zingue et al, 2018;Huang et al, 2020;Tang et al, 2021).…”

Section: Regulation Of Lipid Metabolism In Adipose Tissuementioning

confidence: 99%

Protective effect of phytoestrogens on nonalcoholic fatty liver disease in postmenopausal women

Zhao,

Shi,

Shang

et al. 2023

Front. Pharmacol.

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Non-alcoholic fatty liver disease (NAFLD) is a progressive metabolic disease characterized by hepatic steatosis, inflammation, and fibrosis that seriously endangers global public health. Epidemiological studies have shown that the incidence of non-alcoholic fatty liver disease in postmenopausal women has significantly increased. Studies have shown that estrogen deficiency is the main reason for this situation, and supplementing estrogen has become a new direction for preventing the occurrence of postmenopausal fatty liver. However, although classical estrogen replacement therapy can reduce the incidence of postmenopausal NAFLD, it has the risk of increasing stroke and cardiovascular diseases, so it is not suitable for the treatment of postmenopausal NAFLD. More and more recent studies have provided evidence that phytoestrogens are a promising method for the treatment of postmenopausal NAFLD. However, the mechanism of phytoestrogens in preventing and treating postmenopausal NAFLD is still unclear. This paper summarizes the clinical and basic research evidence of phytoestrogens and reviews the potential therapeutic effects of phytoestrogens in postmenopausal NAFLD from six angles: enhancing lipid metabolism in liver and adipose tissue, enhancing glucose metabolism, reducing oxidative stress, reducing the inflammatory response, regulating intestinal flora, and blocking liver fibrosis (Graphical Abstract).

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Pharmacological Activity and Mechanism of Action of Flavonoids from Diverse Millettia Plant Organs

Kamto

Boniface

2022

NPJ

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Background: There has been increasing interest in the research on flavonoids from plant sources because of their versatile effects reported in various biological studies. The bioavailability, metabolism, and biological activity of flavonoids depend on the configuration, total number of hydroxyl groups, and substitution of functional groups about their nuclear structure. Plant organs are the main dietary source of flavonoids for humans, and have been used as a remedy in traditional medicine. Some examples include Millettia plants which have been reported to contain several flavonoids with pharmacological activity against multifactorial diseases. Aim of the study: The present study summarizes an up-to-date and comprehensive information on the pharmacological activity of flavonoids from plants of the genus Millettia. Methods: The literature information was obtained from published and unpublished materials (theses, dissertations, and textbooks), retrieved from databases, such as Science Direct, SciFinder, PubMed (National Library of Medicine), Scopus, Wiley, American Chemical Society, Springer, and Web of Science. Results: Plants from the genus Millettia contain more than 400 different flavonoids, among which approximately 100 flavonoids were pharmacologically active upon in vitro or in vivo studies. These flavonoids exhibited antioxidant, antiprotozoal, anti-inflammatory, anticancer activities, among others. Conclusion: Flavonoids from Millettia plants were reported to exhibit in vitro antioxidant, antiprotozoal, anti-inflammatory, anticancer activities, etc. These compounds can be used as a starting point for the development of new agents against multifactorial diseases. However, more in vivo experiments, cytotoxicity tests, and detailed mechanism of action of Millettia bioactive flavonoids should be investigated.

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Millettia macrophylla (Fabaceae) phenolic fraction prevents differentiation of 3T3-L1 adipocytes and the increased risks of cardiovascular diseases in ovariectomized rats

Cited by 4 publications

References 51 publications

Phenolic Fractions from Dandelion Leaves and Petals as Modulators of the Antioxidant Status and Lipid Profile in an In Vivo Study

Phenolic Fractions from Dandelion Leaves and Petals as Modulators of the Antioxidant Status and Lipid Profile in an In Vivo Study

Protective effect of phytoestrogens on nonalcoholic fatty liver disease in postmenopausal women

Pharmacological Activity and Mechanism of Action of Flavonoids from Diverse Millettia Plant Organs

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