Millifluidic synthesis of cadmium sulfide nanoparticles and their application in bioimaging

Hong, Liying; Cheung, Tai-Lok; Rao, N. Appaji; Ouyang, Qingling; Wang, Yue; Zeng, Shuwen; Yang, Chengbin; Dang, Cuong; Chong, Peter Han Joo; Liu, Liwei; Law, Wing Cheung; Yong, Ken‐Tye

doi:10.1039/c7ra05401g

Cited by 23 publications

(9 citation statements)

References 47 publications

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“…Solid nanoparticles ranging from 5 to 150 nm in diameter have emerged as promising imaging and therapeutic agents. For example, CdS QDs can be used for optical imaging and gold nanorods for photoacoustic imaging, whereas iron oxide or Gd‐loaded nanoparticles can be applied to magnetic resonance imaging. MDs have been used for simple, robust, and high‐throughput generation of more advanced imaging materials such as protein‐lipid‐coated perfluorobutane microbubbles (about 3 µm) which were incorporated with various silica‐coated nanoparticles (CdSe/ZnS QDs, gold nanorods, iron oxide nanoparticles, and Gd‐loaded mesoporous silica nanoparticles).…”

Section: Biomedical Applications Of Microfluidic Fabricated Materialsmentioning

confidence: 99%

“…By far, CdS and CdSe are the most intensely studied in terms of using microfluidics for their fabrication, offering an effective and simple approach to access ultrasmall nanoparticles with low polydispersity compared to particles generated using conventional methods . Hong et al demonstrated control in the size and morphology of CdS nanocrystals (spheres, nanorods, and multipods, ranging in size from 2.6 to 6.7 nm in diameter) in a millifluidic chip, and used them in in vitro bioimaging using RAW264.7 mice macrophage cells ( Figure b). Tunable photoluminescence is possible by adjusting the molar ratio of the Cd and S precursors, giving rise to shifts in emission peaks under UV irradiation.…”

Section: Biomedical Applications Of Microfluidic Fabricated Materialsmentioning

confidence: 99%

“…b) Schematic of the millifluidic chip used in the synthesis of CdS nanocrystals and the as processed sample under UV irradiation. In vitro bioimaging of RAW264.7 macrophage cells with the CdS nanocrystals . c) Schematic of the fabrication of fluorescent polyethylenimine nanoparticles using a VFD and the associated toxicology studies against MCF‐7 breast cancer cells .…”

Section: Biomedical Applications Of Microfluidic Fabricated Materialsmentioning

confidence: 99%

Section: Biomedical Applications Of Microfluidic Fabricated Materialsmentioning

confidence: 99%

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Microfluidic Devices in Fabricating Nano or Micromaterials for Biomedical Applications

Luo

Zhang

et al. 2019

Adv Materials Technologies

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Nano or microsized particles have been a research focus for decades, and the advancement of microfluidic technologies provides alternative strategies for the synthesis of such materials for various applications. Recent advances of using different microfluidic devices (MDs), including continuous laminar flow, segmented flow, droplet‐based, and other non‐chip‐based microreactors, for the synthesis of nano or microsized particles with specific properties are reviewed, along with their biomedical applications. Different categories of particles fabricated in MDs are summarized to highlight the wide application of the processing platform in the development of novel functional materials.

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Section: Biomedical Applications Of Microfluidic Fabricated Materialsmentioning

confidence: 99%

Section: Biomedical Applications Of Microfluidic Fabricated Materialsmentioning

confidence: 99%

Section: Biomedical Applications Of Microfluidic Fabricated Materialsmentioning

confidence: 99%

Section: Biomedical Applications Of Microfluidic Fabricated Materialsmentioning

confidence: 99%

See 2 more Smart Citations

Microfluidic Devices in Fabricating Nano or Micromaterials for Biomedical Applications

Luo

Zhang

et al. 2019

Adv Materials Technologies

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“…Elevada área superficial e baixa citotoxicidade são características que tornam interessante o uso de materiais nanoparticulados. Na literatura, vários trabalhos relatam a síntese de nanopartículas metálicas, tais como: Au [8][9][10], Ag [11][12][13], Co [14,15] e Cd [16,17].…”

Section: Introductionunclassified

Aplicação de método estatístico no estudo da influência do peróxido de hidrogênio e do borohidreto de sódio na síntese de nanoparticulas de prata (AGNPS)

et al. 2019

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RESUMO Nanomateriais vem atraindo bastante atenção nos últimos anos em virtude das suas propriedades que permitem aplicações em diversas áreas como: química, física, medicina, fármacos e engenharias. No universo dos nanomaterias, as nanopartículas de prata (AgNPs) tem despertado o interesse de vários pesquisadores devido ao seu potencial bactericida. Estudos recentes correlacionaram a eficácia da atividade antimicrobiana com a razão superfície-volume, morfologia, polidispersividade, tamanho de partícula e estabilidade das AgNPs. Este trabalho teve como objetivo compreender a influência do borohidreto de sódio (NaBH4) e do peróxido de hidrogênio (H2O2) nas propriedades das AgNPs. A síntese das AgNPs foi realizada através da redução química de íons de prata com NaBH4, na presença de H2O2 e Citrato de Sódio (SCT). Para determinar a influência causada pelo H2O2 e NaBH4, foram empregados diferentes variações de concentrações e volumes e ao resultado foi aplicado o Teste de Fisher para determinar a significância entre essas variáveis. As amostras foram caracterizadas por Espalhamento Dinâmico de Luz (DLS) e Potencial Zeta. Como resultado, o Teste de Fisher em conjunto com os valores obtidos de tamanho de partícula, estabilidade e polidispersividade determinaram variáveis estatisticamente iguais, ou seja, as variáveis que não influenciam estatisticamente na formação das partículas, bem como, a influência causada pela variação do H2O2 e do NaBH4 nas propriedades das AgNPs. Por fim, a variação da concentração de NaBH4 e volume de H2O2 causam efeitos sob o diâmetro, estabilidade e polidispersividade de AgNPs os quais foram estudados e aqui estão descritos.

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Protein‐Mediated Biosynthesis of Semiconductor Nanocrystals for Photocatalytic NAD(P)H Regeneration and Chiral Amine Production

et al. 2022

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The use of predesigned bioengineered proteins for self‐grown nanomaterials is a promising strategy that opens new scientific directions for biotic‐abiotic nano‐bio hybrid configurations. The unique properties of nanomaterials can alter the original biological paradigm to allow novel metabolic routes or new activation triggers. In this work, we present a synthetic methodology for self‐grown cadmium sulfide quantum dots in a 12‐mer bioengineered stable protein 1 under ambient conditions. The sized controlled crystalline QDs are characterized and utilized for NADPH regeneration that is in turn used for the activation of the imine reductase enzyme. The presented nano‐bio hybrid system enables the production of a single enantiomeric product that is required for the pharmaceutical industry. Our designed system presents superior activity and can continuously operate for at least 22 hrs with 82 % conversion efficiency. The obtained results may lay the foundations for future nano‐bio hybrid systems that can operate both in vitro and in vivo.

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Millifluidic synthesis of cadmium sulfide nanoparticles and their application in bioimaging

Abstract: In this work, a miniature fluidic synthesis platform utilizing millimeter dimension channels yielding highly reproducible batch synthesis of luminescent cadmium sulfide (CdS) quantum dots and nanocrystals is demonstrated.

Cited by 23 publications

References 47 publications

Microfluidic Devices in Fabricating Nano or Micromaterials for Biomedical Applications

Microfluidic Devices in Fabricating Nano or Micromaterials for Biomedical Applications

Aplicação de método estatístico no estudo da influência do peróxido de hidrogênio e do borohidreto de sódio na síntese de nanoparticulas de prata (AGNPS)

Protein‐Mediated Biosynthesis of Semiconductor Nanocrystals for Photocatalytic NAD(P)H Regeneration and Chiral Amine Production

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