Millifluidics, microfluidics, and nanofluidics: manipulating fluids at varying length scales

Chen, L.; Yang, Chenjing; Xiao, Yao; Yan, Xiaoxiao; Hu, Lingfei; Eggersdorfer, Maximilian L.; Chen, D.; Weitz, David A.; Ye, F.

doi:10.1016/j.mtnano.2021.100136

Cited by 73 publications

(46 citation statements)

References 147 publications

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“…Poly(vinyl alcohol) (PVA) has good biocompatibility , and elasticity, so it is the most commonly used material for fabricating embolic microspheres. − Currently, the methods for fabricating PVA microspheres mainly include emulsification, followed by chemical cross-linking, ,, spray drying, , freezing–thawing, , and microfluidic technology. − For example, Li et al dispersed PVA aqueous solution into the mixed solution of Span 80 and n -heptane by stirring to form water-in-oil droplets and then added glutaraldehyde (GA) as a chemical cross-linking agent to prepare PVA microspheres . Avcioglu et al prepared PVA powder particles by the spray drying method .…”

Section: Introductionmentioning

confidence: 99%

Controllable Fabrication of Monodisperse Poly(vinyl alcohol) Microspheres with Droplet Microfluidics for Embolization

Yang

Deng

et al. 2022

Ind. Eng. Chem. Res.

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A novel strategy based on droplet microfluidics is developed for facile fabrication of monodisperse poly(vinyl alcohol) (PVA) microspheres with controllable sizes and elastic properties for embolization. Monodisperse emulsion droplets are fabricated as templates by dissolving PVA and boric acid in the aqueous disperse phase, and chemical cross-linking between PVA and boric acid inside droplet templates is triggered by adding NaOH into the downstream receiving solution. The cross-linking speed and degree between PVA and boric acid inside droplet templates can be controlled by adjusting the NaOH concentration, height, and rotating speed of the receiving solution. The sizes of droplet templates and resultant cross-linked PVA microspheres can be precisely controlled by adjusting the characteristic dimensions of the microfluidic device as well as the flow rates of disperse and continuous phases. Moreover, the elastic, swelling, and drug-loading properties of PVA microspheres can be controllably regulated by adjusting the ratio of PVA to boric acid in the disperse phase. With an in vitro chip, excellent embolization performances of the fabricated PVA microspheres are visually demonstrated. The proposed strategy provides a facile and efficient route for fabricating monodisperse PVA microspheres with a controllable size and elastic, swelling, drug-loading, and drug-release properties, which are highly desired for applications in embolization therapy.

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Section: Introductionmentioning

confidence: 99%

Controllable Fabrication of Monodisperse Poly(vinyl alcohol) Microspheres with Droplet Microfluidics for Embolization

Yang

Deng

et al. 2022

Ind. Eng. Chem. Res.

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“…[7,8] In contrast to traditional chemical processes, flow chemistry technologies prevail in continuous chemical reactions or separations in small flow channels or tubes, which have large surface-to-volume ratios to enhance mixing/ transport performances. [9][10][11][12] Many cases have shown the advantages of the flow chemistry method in terms of continuous operation, [13] high reaction yield, [14] low hazardous waste, [15] environmentally-friendly route, [16] and inherent safety chemical reaction. [17] In the application of flow chemistry, microdispersion technology is outstanding in creating tiny bubbles and droplets, which are only tens or hundreds of microns in diameter, with large specific surface areas and micro-liter level volumes.…”

Section: Introductionmentioning

confidence: 99%

Insight into Microdispersion Flows with a Novel Video Deep Learning Method

Zhang

Kang

Huang

et al. 2022

Advanced Intelligent Systems

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Microdispersion technology is an important part of the flow chemistry method in creating tiny bubbles or droplets for enhancing mass/heat transfer performance, in which the dispersed flow condition plays a central role. Currently, most microdispersion flow characterization works are conducted by manual analysis on microscopic images, suffering from long analysis time and limited accessible information. Herein, taking the advantage of convolutional neural networks, TrackFit is proposed as an efficient video deep learning method for a precise, fast, and comprehensive investigation of microdispersion states. TrackFit is capable of recognizing bubble instances, tracking them in the microscope sight, and unprecedentedly inferring bubble diameter, location, velocity, as well as sphericity in an intelligent way. TrackFit achieves small measurement errors of diameter (8 μm) and velocity (0.08 mm s−1) on the test dataset after deepening the neural network backbone and adopting the data augmentation technique. When applied to inexperienced data, the TrackFit output relationship of bubble diameter to flow rate is consistent with previous manual results, but with a beyond‐human efficiency (≈500 times higher). TrackFit not only works as a core method of an intelligent microdispersed fluid characterization system, but also suggests a promising potential for real‐time microdispersion process analysis in the future.

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“…As a novel approach to precisely control and manipulate cells and fluids in the microscale space, microfluidics provides new insights for on-site sample preparation owing to the advantages of miniaturization, a low device cost, small-sample consumption, and high integration [ 13 , 14 ]. To date, various novel microfluidic devices have been developed to realize separation [ 15 , 16 ], ordering [ 17 , 18 ], concentration [ 19 , 20 ], trapping [ 21 ], enrichment [ 22 ], filtration [ 23 , 24 ], and lysis [ 25 , 26 ] of cells on a single chip.…”

Section: Introductionmentioning

confidence: 99%

Hand-Powered Inertial Microfluidic Syringe-Tip Centrifuge

Xiang

Zhang

2021

Biosensors

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Conventional sample preparation techniques require bulky and expensive instruments and are not compatible with next-generation point-of-care diagnostic testing. Here, we report a manually operated syringe-tip inertial microfluidic centrifuge (named i-centrifuge) for high-flow-rate (up to 16 mL/min) cell concentration and experimentally demonstrate its working mechanism and performance. Low-cost polymer films and double-sided tape were used through a rapid nonclean-room process of laser cutting and lamination bonding to construct the key components of the i-centrifuge, which consists of a syringe-tip flow stabilizer and a four-channel paralleled inertial microfluidic concentrator. The unstable liquid flow generated by the manual syringe was regulated and stabilized with the flow stabilizer to power inertial focusing in a four-channel paralleled concentrator. Finally, we successfully used our i-centrifuge for manually operated cell concentration. This i-centrifuge offers the advantages of low device cost, simple hand-powered operation, high-flow-rate processing, and portable device volume. Therefore, it holds potential as a low-cost, portable sample preparation tool for point-of-care diagnostic testing.

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Millifluidics, microfluidics, and nanofluidics: manipulating fluids at varying length scales

Cited by 73 publications

References 147 publications

Controllable Fabrication of Monodisperse Poly(vinyl alcohol) Microspheres with Droplet Microfluidics for Embolization

Controllable Fabrication of Monodisperse Poly(vinyl alcohol) Microspheres with Droplet Microfluidics for Embolization

Insight into Microdispersion Flows with a Novel Video Deep Learning Method

Hand-Powered Inertial Microfluidic Syringe-Tip Centrifuge

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