Aim of study: The power consumption of machining operations is an important part of the total production cost. Therefore, in this study, an artificial neural network (ANN) model was developed to model the effects of treatment, rotation speed, cutting depth, and feed rate on power consumption in the wood milling process. Material and methods: A multilayer feed-forward ANN was employed for the prediction of power consumption. The accuracy of the model was assessed by performance indicators such as MAPE, RMSE, and R². Main results: It has been observed that the ANN model yielded very satisfactory results with acceptable deviations. The MAPE, RMSE, and R 2 values were obtained as 7.533, 0.027, and 0.9737 %, respectively, in the testing phase. Furthermore, it was found that power consumption decreased with decreasing of feed rate and cutting depth. Research highlights: The findings of this study can be used effectively in the forest industry to reduce the experimental time and costs.