2022
DOI: 10.1038/s41390-022-01964-6
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Milrinone effects on cardiac mitochondria, hemodynamics, and death in catecholamine-infused rats

Abstract: BACKGROUND: Catecholamine-storm is considered the major cause of enterovirus 71-associated cardiopulmonary death. To elucidate the effect of milrinone on cardiac mitochondria and death, a rat model of catecholamine-induced heart failure was investigated. METHODS: Young male Spray-Dawley rats received a continuous intravenous infusion of norepinephrine then followed by cotreatment with and without milrinone or esmolol. Vital signs were monitored and echocardiography was performed at indicated time points. At th… Show more

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