Milrinone improves lung compliance in patients receiving mechanical ventilation for cardiogenic pulmonary edema

Takeda, Satoru; Matsumura, Junya; Ikezaki, Hiroyuki; Kim, C.; Sato, Naoki; Nakanishi, Kazuhiro; Sakamoto, Atsuhiro; Ogawa, Ryo; Tanaka, Keiji

doi:10.1034/j.1399-6576.2003.00124.x

Cited by 5 publications

(1 citation statement)

References 23 publications

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“…However, to date, there has not been any randomized controlled trial in the pediatric population with milrinone as treatment of cardiogenic pulmonary edema. In fact, lung compliance improves with milrinone use in the adult population receiving mechanical ventilation for cardiogenic pulmonary edema [13]. In an experimental study of animal models, milrinone has been found to attenuate post resuscitation myocardial dysfunction [11].…”

Section: Discussionmentioning

confidence: 99%

Cardiac failure following inadvertent administration of high-dose epinephrine subcutaneously

Tran

Fraser

Hawrylyshyn

et al. 2015

J Pediatr Intensive Care

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Our aim is to report the consequences of epinephrine toxicity leading to cardiac failure in a child and the successful management with dopamine and milrinone. A previously healthy 13-year-old girl undergoing a left tympanomastoidectomy was inadvertently administered 10 mL of 1:1000 epinephrine subcutaneously (0.175 mg/kg) on the left post auricular region in lieu of lidocaine. She developed sudden supraventricular tachycardia, hypertension and flash pulmonary edema. She was initially treated with propofol, nitrogycerin and increased peak end-expiratory pressure. Within 4 h, she remained tachycardic, but was hypotensive with an increased central venous pressure. Electrocardiogram and echocardiogram investigations showed ST changes indicative of myocardial ischemia and globally reduced function, respectively. Dopamine infusion was administered, together with milrinone, resulting in a gradual improvement of cardiac function within 3 days. She was transitioned to enalapril and discharged home. This case highlights the clinical features of high dose epinephrine toxicity secondary to iatrogenic subcutaneous overdose followed by hypotension and pulmonary edema as a possible late effect of epinephrine and the successful management of secondary cardiac failure with administration of dopamine, milrinone and enalapril.

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Section: Discussionmentioning

confidence: 99%

Cardiac failure following inadvertent administration of high-dose epinephrine subcutaneously

Tran

Fraser

Hawrylyshyn

et al. 2015

J Pediatr Intensive Care

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Restrictive Lung Function Is Related to Sympathetic Hyperactivity in Patients With Heart Failure

Joho

Ushijima

Akabane

et al. 2017

Journal of Cardiac Failure

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Effects of Milrinone on Contractility and Cyclic Adenosine Monophosphate Production Induced by β1- and β2-Adrenergic Receptor Activation in Human Myocardium

Carceles

Fuentes

Aroca

et al. 2007

Clinical Therapeutics

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Milrinone improves lung compliance in patients receiving mechanical ventilation for cardiogenic pulmonary edema

Abstract: Milrinone-induced improvement in lung compliance along with an improvement of hemodynamics was found together with an inverse relationship between compliance and mean pulmonary artery pressure.

Cited by 5 publications

References 23 publications

Cardiac failure following inadvertent administration of high-dose epinephrine subcutaneously

Cardiac failure following inadvertent administration of high-dose epinephrine subcutaneously

Restrictive Lung Function Is Related to Sympathetic Hyperactivity in Patients With Heart Failure

Effects of Milrinone on Contractility and Cyclic Adenosine Monophosphate Production Induced by β1- and β2-Adrenergic Receptor Activation in Human Myocardium

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