Mimicking the human smell sensing mechanism with an artificial nose platform

Lee, Sang Hun; Kwon, Oh Seok; Song, Hyun Seok; Park, Seon Joo; Sung, Jong Hwan; Jang, Jyongsik; Park, Tai Hyun

doi:10.1016/j.biomaterials.2011.11.044

Cited by 109 publications

(76 citation statements)

References 38 publications

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“…67,68 Our results may also be especially relevant for the development of artificial molecular sensors, which could use the principles we have described in their design to aid in distinguishing chemical species based on their vibrational spectra. 34,69,70 VII. ACKNOWLEDGEMENTS A. C. would like to thank V. Vedral for fruitful discussions.…”

Section: Discussionmentioning

confidence: 99%

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Dissipation enhanced vibrational sensing in an olfactory molecular switch

Chęcińska

Pollock

Heaney

et al. 2015

The Journal of Chemical Physics

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Motivated by a proposed olfactory mechanism based on a vibrationally-activated molecular switch, we study electron transport within a donor-acceptor pair that is coupled to a vibrational mode and embedded in a surrounding environment. We derive a polaron master equation with which we study the dynamics of both the electronic and vibrational degrees of freedom beyond previously employed semiclassical (MarcusJortner) rate analyses. We show: (i) that in the absence of explicit dissipation of the vibrational mode, the semiclassical approach is generally unable to capture the dynamics predicted by our master equation due to both its assumption of one-way (exponential) electron transfer from donor to acceptor and its neglect of the spectral details of the environment; (ii) that by additionally allowing strong dissipation to act on the odorant vibrational mode we can recover exponential electron transfer, though typically at a rate that differs from that given by the Marcus-Jortner expression; (iii) that the ability of the molecular switch to discriminate between the presence and absence of the odorant, and its sensitivity to the odorant vibrational frequency, are enhanced significantly in this strong dissipation regime, when compared to the case without mode dissipation; and (iv) that details of the environment absent from previous Marcus-Jortner analyses can also dramatically alter the sensitivity of the molecular switch, in particular allowing its frequency resolution to be improved. Our results thus demonstrate the constructive role dissipation can play in facilitating sensitive and selective operation in molecular switch devices, as well as the inadequacy of semiclassical rate equations in analysing such behaviour over a wide range of parameters.

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Section: Discussionmentioning

confidence: 99%

“…[31][32][33][34][35] The prevailing theory, known as the lock-and-key model, explains how the odorant size and shape can provide discrimination in the receptor. 36 However, this theory does not give a straightforward explanation of why it a) These authors contributed equally to the work.…”

Section: Introductionmentioning

confidence: 99%

Dissipation enhanced vibrational sensing in an olfactory molecular switch

Chęcińska

Pollock

Heaney

et al. 2015

The Journal of Chemical Physics

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show abstract

“…Various odorant detection tools have been developed using olfactory receptors (ORs). The OR protein-based detection systems have shown good performance with a combination of various nanomaterial-based electronic platforms (Du et al, 2013;Jin et al, 2012;Kim et al, 2009;Lee et al, 2012aLee et al, , 2012bOh et al, 2011;Park et al, 2012). Odorant-binding proteins (OBPs) and chemosensory proteins (CSPs), have also been used for the detection of odorants (Ko and Park, 2008;Ko et al, 2010;Liu et al, 2013;Pelosi et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Cell-based microfluidic platform for mimicking human olfactory system

Lee

Park

2015

Biosensors and Bioelectronics

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“…Binding of the odorant to the olfactory receptor was translated into a detectable signal specific for the respective odorant. Recently, ultrasensitive carbon nanotube and graphene based electronic noses were developed [74][75][76]. Further, a bioelectronic tongue platform was presented based on a field effect transistor functionalized with human taste receptors [77].…”

Section: Sensorsmentioning

confidence: 99%

Organic Bioelectronic Tools for Biomedical Applications

2015

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Abstract:Organic bioelectronics forms the basis of conductive polymer tools with great potential for application in biomedical science and medicine. It is a rapidly growing field of both academic and industrial interest since conductive polymers bridge the gap between electronics and biology by being electronically and ionically conductive. This feature can be employed in numerous ways by choosing the right polyelectrolyte system and tuning its properties towards the intended application. This review highlights how active organic bioelectronic surfaces can be used to control cell attachment and release as well as to trigger cell signaling by means of electrical, chemical or mechanical actuation. Furthermore, we report on the unique properties of conductive polymers that make them outstanding materials for labeled or label-free biosensors. Techniques for electronically controlled ion transport in organic bioelectronic devices are introduced, and examples are provided to illustrate their use in self-regulated medical devices. Organic bioelectronics have great potential to become a primary platform in future bioelectronics. We therefore introduce current applications that will aid in the development of advanced in vitro systems for biomedical science and of automated systems for applications in neuroscience, cell biology and infection biology. Considering this broad spectrum of applications, organic bioelectronics could lead to timely detection of disease, and facilitate the use of remote and personalized medicine. As such, organic bioelectronics might contribute to efficient healthcare and reduced hospitalization times for patients. OPEN ACCESSElectronics 2015, 4 880

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Mimicking the human smell sensing mechanism with an artificial nose platform

Cited by 109 publications

References 38 publications

Dissipation enhanced vibrational sensing in an olfactory molecular switch

Dissipation enhanced vibrational sensing in an olfactory molecular switch

Cell-based microfluidic platform for mimicking human olfactory system

Organic Bioelectronic Tools for Biomedical Applications

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