Mimics of melanoma in reflectance confocal microscopy

Pogorzelska-Antkowiak, Anna; Calik, Jacek

doi:10.1111/ijd.15306

Cited by 4 publications

(3 citation statements)

References 35 publications

(33 reference statements)

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“…Concurrently, the minority of nevi presented concerning microscopic features such as nonedged papillae, or atypical cells. Scarce atypical cells in the DEJ are observed in other melanocytic nevi, such as halo nevus or compound nevus, and are of no clinical significance 22 . Considering reassuring RCM data, and stability of the lesions at 6‐month follow‐up, no nevi were surgically removed or biopsied during the study.…”

Section: Discussionmentioning

confidence: 99%

Application of dermoscopy and reflectance confocal microscopy in vivo in the evaluation of nevi in children

Pogorzelska‐Antkowiak,

Gonzalez

2024

Pediatric Dermatology

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BackgroundMelanocytic nevi are frequently observed in the pediatric population. While newly acquired nevi can appear during childhood, congenital nevi can continue to grow and clinically change, making patient caregivers concerned. Reflectance confocal microscopy (RCM) in vivo is a noninvasive tool that might enhance the diagnostic accuracy of dermoscopy, reducing the rate of unnecessary surgical procedures. This study aimed to assess the utility of RCM in increasing the diagnostic accuracy of pediatric melanocytic nevi that show pigmentation changes or grow rapidly.MethodsPediatric patients who presented between January 2022 and February 2023 in a single institution with rapidly growing melanocytic nevi or nevi that presented changes in the pigmentation were included in the study. All nevi were evaluated by means of dermoscopy and RCM.ResultsForty‐two patients with a total of 42 melanocytic nevi were included. Most lesions showed a honeycombed pattern (n = 21, 50%). On RCM, only 3 of 42 nevi presented atypical cells within the epidermis (7.1%). Evaluation of the dermoepidermal junction (DEJ) revealed the predominance of the meshwork pattern (n = 22, 52.4%). Notably, features considered significant for atypical melanocytic nevi included 9 nevi with scant atypical melanocytes (21.4%) and 3 nevi with nonedge papillae (7.1%). None of the studied lesions required biopsy among this cohort.ConclusionsMost rapidly growing and clinically changing nevi rarely exhibit single atypical cells in the DEJ. The RCM served as a valuable adjunct to dermoscopy, allowing reassurance in the evaluation of these lesions.

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Section: Discussionmentioning

confidence: 99%

Application of dermoscopy and reflectance confocal microscopy in vivo in the evaluation of nevi in children

Pogorzelska‐Antkowiak,

Gonzalez

2024

Pediatric Dermatology

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“…In symmetric and well-demarcated cases, differential diagnosis with melanoma is easier. The difficulties may occur in lesions with non-specific dermoscopic patterns [15][16][17][18]. Especially when blue colour within the lesion is observed.…”

Section: Discussionmentioning

confidence: 99%

“…A broadened honeycomb pattern of the epidermis, disarranged epidermal pattern, and the presence of small pagetoid cells were more likely correlated with a melanoma diagnosis. Non-edged papillae were significant for MM diagnosis, while dense junctional nests were more common in SN [ 12 , 18 ]. Previous studies showed different RCM epidermal features between MM and SN; a correlation between striking cells pleomorphism and melanoma was found [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Spitz nevus and melanoma: evaluation with dermoscopy and reflectance confocal microscopy

Pogorzelska-Antkowiak¹,

Słowińska²,

Farinazzo³

et al. 2023

pdia

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Introduction: Spitz nevi (SN) include a wide range of benign melanocytic nevi, which are controversial due to their morphologic resemblance to melanoma (MM). Aim: To describe dermoscopic and reflectance confocal microscopic (RCM) features of SN compared to MM and assess the RCM utility in the differential diagnosis. Material and methods: We performed a multicentre retrospective analysis of MM and SN evaluated with dermoscopy and reflectance confocal microscopy. Three RCM mosaics were obtained for each lesion. Nine dermoscopic and twenty-one microscopic features were assessed for each lesion. Results: A total of 26 lesions (15 SN and 11 MM) were included. Dermoscopically, most SN showed a "starburst" pattern. Asymmetry was marked in 8 MM. There were 6 dermoscopic features significantly more prevalent in MM than in SN. RCM showed that an atypical honeycomb pattern, atypical infiltration, and disarray of the epidermis were significant for MM. SN mostly revealed a typical honeycomb pattern. At the DEJ, most of SN had a meshwork pattern; MM revealed an atypical meshwork pattern. Atypical cells and sheet-like structures were observed in most MM. Conclusions: A combined approach using dermoscopy and RCM supports the differential diagnosis of SN and MM. Although our study showed some significant differences between SN and MM in RCM, further research on a larger group should be considered.

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Development of a portable reflectance confocal microscope and its application in the noninvasive in vivo evaluation of mesenchymal stem cell-promoted cutaneous wound healing

et al. 2022

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Mimics of melanoma in reflectance confocal microscopy

Cited by 4 publications

References 35 publications

Application of dermoscopy and reflectance confocal microscopy in vivo in the evaluation of nevi in children

Application of dermoscopy and reflectance confocal microscopy in vivo in the evaluation of nevi in children

Spitz nevus and melanoma: evaluation with dermoscopy and reflectance confocal microscopy

Development of a portable reflectance confocal microscope and its application in the noninvasive in vivo evaluation of mesenchymal stem cell-promoted cutaneous wound healing

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