Mimics of pilomatrixomas in fine-needle aspirates

Sánchez, Carlos Sánchez; Bascuñana, Alberto Giménez; Quirante, Francisco A. Pastor; Romero, Maria; Fernández, Joaquín Campos; Pérez, J.; Parra, Diego Martínez; Pérez‐Guillermo, Miguel

doi:10.1002/(sici)1097-0339(199602)14:1<75::aid-dc16>3.0.co;2-a

Cited by 48 publications

(16 citation statements)

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“…In their review of fine-needle aspiration of eight cases of pilomatrixoma, Sanchez et al recommended the importance of examining smears stained by Papanicolaou, as well as Diff-Quik stains, since the nuclei of basaloid cells may appear unduly enlarged in the smears stained by Diff-Quik. 14 The presence of shadow cells with characteristic central pale nuclear zone has been repeatedly reported in the literature as the most important cytologic feature for the diagnosis of pilomatrixoma. However, despite their abundance in histologic sections, their detection was reported to be difficult in the cytologic smears and they may not be present at all.…”

Section: Discussionmentioning

confidence: 89%

“…There are several reports in the literature describing its cytologic features and addressing the main differential diagnosis and its diagnostic pitfalls. [3][4][5][6][7][8][9][10][11][12][13][14] However, a review of the literature showed that out of the 34 reported cases, a correct cytologic diagnosis was made in only 12 cases, one of these on repeat FNAB. Most of the cases were reported as carcinoma, mainly squamous cell carcinoma, or suggestive of carcinoma (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…13,14 In this paper, we present the cytologic findings in three cases of pilomatrixoma in which fineneedle aspiration biopsy (FNAB) was performed. Definitive diagnosis of pilomatrixoma was rendered in only two of these cases.…”

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confidence: 99%

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Pilomatrixoma: Fine-Needle Aspiration Cytology a Report of Three Cases

Tulbah

Akhtar

1997

Ann Saudi Med

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A Tulbah, M Akhtar, Pilomatrixoma: Fine-Needle Aspiration Cytology a Report of Three Cases. 1997; 17(1): 88-91 Pilomatrixoma, or calcifying epithelioma of Malherbe, is a benign tumor of skin appendages with presumed differentiation towards hair cortical cells. The term pilomatrixoma is preferred to the former name of "calcifying epithelioma of Malherbe," which may give the unwary clinician a false impression that the lesion is malignant. It manifests clinically as a firm, deep-seated nodule, located mainly on the head, neck and upper extremities. It may arise in persons of any age, but about 40% arise in children younger than 10 years and 60% in the second decade of life. Histologically, it is composed of solid nests of small basaloid cells. The key feature is the presence of abrupt keratinization of these cells, leading to the formation of ghost or shadow cells. Foreign body reaction, calcification and ossification are common secondary events.1,2 Although several studies describing the cytologic features of pilomatrixoma have been reported in the literature, this lesion continues to cause difficulty in diagnosis on a cytologic basis. 13,14 In this paper, we present the cytologic findings in three cases of pilomatrixoma in which fineneedle aspiration biopsy (FNAB) was performed. Definitive diagnosis of pilomatrixoma was rendered in only two of these cases. The cytologic features of pilomatrixoma are discussed with a review of the literature. Material and MethodsThree cases of pilomatrixoma in which FNAB was performed form the basis of this study. Two of these underwent surgical resection following the FNAB, while in the third case no surgery was performed, since FNAB diagnosis was definitive. Fine-needle biopsy was done using a 25 x 1 inch and a 23 x 1 inch gauge needle, without aspiration. The material was smeared on unfrosted slides and the smears were air-dried and stained by Diff-Quik method. Case Reports Case 1A two-year-old female presented with a two-month history of a mass on the back of the neck, which gradually increased in size. The lesion was 2 x 2 cm, hard, mobile, and nontender, and located in the occipital area. The overlying skin was normal. FNAB was performed, followed by surgical resection. Case 2A 12-year-old female presented with a two-and-a-half-month history of a mass in the preauricular area on the right side of the face. It was slightly tender, firm and mobile. The skin overlying it was tethered and discolored. FNAB was performed, followed by surgical resection. Case 3An 11-year-old female presented with a 0.5-cm firm, mobile subcutaneous nodule on the shoulder. FNAB was performed. Results Cytologic FindingsThe smears in all three cases were moderately cellular (Figure 1). The main cell population was basaloid. These were present as sheets of various sizes, as well as isolated cells. The cells had a high nuclear cytoplasmic ratio and scanty basophilic cytoplasm. Their nuclei were round to oval with fairly regular outline and prominent nucleoli

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Pilomatrixoma: Fine-Needle Aspiration Cytology a Report of Three Cases

Tulbah

Akhtar

1997

Ann Saudi Med

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“…However, other entities to be considered in the differential diagnosis include epidermal inclusion cyst, foreign body reaction, calcinosis cutis, and lipoma. As described by Sanchez and associates, the classic cytologic appearance of pilomatrixoma consists of varying amounts of basaloid and ghost cells [9]. Basaloid cells are basophilic and are about three times the size of a lymphocyte.…”

Section: Discussionmentioning

confidence: 95%

An 8-Year-Old Girl with Multiple Subcutaneous Nodules: Pilomatrixoma

Kılıçaslan¹

2012

Pediatr Therapeut

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“…The findings of fine needle aspiration biopsy can be misleading and can be mistaken for squamous cell carcinoma due to good cellularity, high nuclear/cytoplasmic ratio and anucleated squamous cells 10,18,19 .…”

Section: Discussionmentioning

confidence: 99%

Pilomatricoma-Analysis of 15 Cases With Review of Literature

Jeshtadi¹,

Neelima²,

Archana³

et al. 2013

jemds

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A pilomatricoma is a benign appendage tumor related to hair cells matrix. Pilomatricoma usually occurs as a solitary firm lesion with predilection for head and neck, and upper extremities. It is more common in children. AIM: The objective of this study is to know the clinical presentation and histopathology of this condition. MATERIALS AND METHODS: This is a 4 yrs retrospective and 1 yr prospective study carried in Upgraded Department of pathology, Osmania general hospital between June 2008 and May 2013. Patients data such as sex, age, site of occurrence, clinical presentation were considered.The study included 15 patients with histopathologically diagnosed pilomatricoma. RESULTS: A total of 15 cases were included in our study with an age range from 6-36 year.Out of which benign tumors were 14 (93.3%) and malignant 1 (6.7%). The female: male ratio was 3:2. The sizes of the tumours range from 2-3cm. Most of the cases were seen in Upper extremity-7 cases (46.7%), followed by Head and neck region-6 cases (40.0%) and Trunk-2 cases (13.3%). The most common clinical presentation was sebaceous cyst. CONCLUSION: Pilomatricoma generally present as firm subcutaneous nodules in children and young adults and are often misdiagnosed. The physicians and surgeons should be familiar with this entity and consider it in the differential diagnosis of a superficial mass.

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Mimics of pilomatrixomas in fine-needle aspirates

Cited by 48 publications

References 4 publications

Pilomatrixoma: Fine-Needle Aspiration Cytology a Report of Three Cases

Pilomatrixoma: Fine-Needle Aspiration Cytology a Report of Three Cases

An 8-Year-Old Girl with Multiple Subcutaneous Nodules: Pilomatrixoma

Pilomatricoma-Analysis of 15 Cases With Review of Literature

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