Mimosa pudica mucilage nanoparticles of losartan potassium: Characterization and pharmacodynamics evaluation

Ghumman, Shazia Akram; Mahmood, Arshad; Noreen, Sobia; Hameed, Huma; Kausar, Rizwana; Rana, MA; Aslam, Asma

doi:10.1016/j.jsps.2023.101695

Cited by 6 publications

(1 citation statement)

References 38 publications

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“…These NPs were collected by centrifuging at 10,000 rpm and the pellet was washed thoroughly with double-distilled deionized water, followed by the final rinse with ethanol. Nanoparticles were dried in a hot air oven at 80 °C and stored at 4 °C for further use 21 .…”

Section: Methodsmentioning

confidence: 99%

Phytofabricated bimetallic synthesis of silver-copper nanoparticles using Aerva lanata extract to evaluate their potential cytotoxic and antimicrobial activities

Thirumoorthy,

Balasubramanian,

George

et al. 2024

Sci Rep

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In this study, we demonstrate the green synthesis of bimetallic silver-copper nanoparticles (Ag–Cu NPs) using Aerva lanata plant extract. These NPs possess diverse biological properties, including in vitro antioxidant, antibiofilm, and cytotoxic activities. The synthesis involves the reduction of silver nitrate and copper oxide salts mediated by the plant extract, resulting in the formation of crystalline Ag–Cu NPs with a face-centered cubic structure. Characterization techniques confirm the presence of functional groups from the plant extract, acting as stabilizing and reducing agents. The synthesized NPs exhibit uniform-sized spherical morphology ranging from 7 to 12 nm. They demonstrate significant antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, inhibiting extracellular polysaccharide secretion in a dose-dependent manner. The Ag–Cu NPs also exhibit potent cytotoxic activity against cancerous HeLa cell lines, with an inhibitory concentration (IC50) of 17.63 µg mL−1. Additionally, they demonstrate strong antioxidant potential, including reducing capability and H2O2 radical scavenging activity, particularly at high concentrations (240 µg mL−1). Overall, these results emphasize the potential of A. lanata plant metabolite-driven NPs as effective agents against infectious diseases and cancer.

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Section: Methodsmentioning

confidence: 99%