2001
DOI: 10.1016/s0161-5890(01)00084-0
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Mimotopes of the hyper variable region 1 of the hepatitis C virus induce cross-reactive antibodies directed against discontinuous epitopes

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Cited by 29 publications
(18 citation statements)
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“…Another phage peptide mimotope (sequence GLLVWSDEL) with a b12 binding motif of M/V SD ( represents an aromatic amino acid) was identified but was only able to elicit weakly gp120 reactive immune responses [83]. Thus, while peptide mimotopes for the b12 epitope have yielded limited results, peptide mimotopes have been shown in other systems to elicit both cross reactive and protective immune responses [38,39,270,271,285,286]. Again like outer domain constructs, peptide mimotopes will need to better mimic the b12 epitope for this strategy to succeed.…”
Section: Targeting the Cd4 Binding Sitementioning
confidence: 99%
“…Another phage peptide mimotope (sequence GLLVWSDEL) with a b12 binding motif of M/V SD ( represents an aromatic amino acid) was identified but was only able to elicit weakly gp120 reactive immune responses [83]. Thus, while peptide mimotopes for the b12 epitope have yielded limited results, peptide mimotopes have been shown in other systems to elicit both cross reactive and protective immune responses [38,39,270,271,285,286]. Again like outer domain constructs, peptide mimotopes will need to better mimic the b12 epitope for this strategy to succeed.…”
Section: Targeting the Cd4 Binding Sitementioning
confidence: 99%
“…One such immunodominant linear epitope lies within the first hypervariable region (HVR-1) of E2 (68). The use of conserved HVR-1 mimotopes has been proposed to overcome problems of restricted specificity (11,56,70), but it is not yet known whether this approach will be successful. We and others have reported that a region immediately downstream of HVR-1 contains epitopes which elicit antibodies that potently inhibit CD81 binding (15,27,48,64).…”
mentioning
confidence: 99%
“…The black line indicates the flow cytometric data generated using an irrelevant mouse mAb, and the gray line indicates the flow cytometric data generated with each mAb the peptide epitope. This may be a quite a general phenomenon that should be borne in mind when we try to mimic the three-dimensional structures of an epitope with a linear peptide, and runs contrary to reports that argue in favor of the possibility of mimotope vaccine (Demangel et al 1998;Pincus et al 1998;Arnon et al 2000;Harris et al 2000;Kieber-Emmons et al 2000;Olszewska et al 2000;Roccasecca et al 2001;Steward 2001;Zucchelli et al 2001).…”
Section: Discussionmentioning
confidence: 68%
“…Many of these peptides were shown to specifically bind to the antigen binding region of antibody. In addition to this immunoreactivity, some peptides have recently been reported to be able to elicit an antibody response against the original antigen, suggesting their possible uses as mimotope vaccines (Demangel et al 1998;Pincus et al 1998;Arnon et al 2000;Harris et al 2000;Kieber-Emmons et al 2000;Olszewska et al 2000;Roccasecca et al 2001;Steward 2001;Zucchelli et al 2001). …”
mentioning
confidence: 99%