Minced muscle autografting improves bone healing but not muscle function in a porcine composite injury model

McKinley, Todd O.; Natoli, Roman M; Janakiram, Naveena B.; Warden, Stuart J.; Fuchs, Robyn K.; Gunderson, Zachary J.; Diggins., Nichlaus; Sun, Seungyup; Kolettis, George; Goldman, Stephen M.; Dearth, Christopher L.; Mendenhall, Stephen K.; Staut, Caio A.; Kacena, Melissa A.; Corona, Benjamin T.

doi:10.1002/jor.25551

Cited by 4 publications

(1 citation statement)

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“…Bone tissue is a highly dynamic, complex vascularized tissue that undergoes continuous remodeling throughout life (Hoseinpour and Shariatinia, 2021). While bone tissue has a degree of selfhealing ability, its ability to repair itself is limited when faced with severe injuries, such as trauma, infection, tumor removal, and joint revision (McKinley et al, 2023). These diseases are beyond the ability of humans to heal themselves, making it difficult to recover through autologous bone tissue regeneration alone.…”

Section: Introductionmentioning

confidence: 99%

Application of seaweed polysaccharide in bone tissue regeneration

Jin,

Yu,

et al. 2023

Front. Mar. Sci.

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Regeneration is a complex process influenced by many independent or combined factors, including inflammation, proliferation, and tissue remodeling. The ocean, the most extensive resource on Earth, is rich in Seaweed. With increasing research in recent years, researchers have discovered that seaweed polysaccharides have various pharmacological effects, including a particular efficacy in promoting bone tissue regeneration. However, the application of this material in the field of bone tissue engineering is very limited. However, there are few studies on the polysaccharide at home and abroad, and little is known about its potential application value in bone repair. In addition, the bioavailability of the seaweed polysaccharide is also low, and there are still many problems to be solved. For example, the ease of solubility of fucoidan in water is a key issue that restricts its practical application. In this review, we summarize the applications and mechanisms of seaweed polysaccharides in bone healing. We also propose to combine seaweed polysaccharides with novel technologies through different types of preparations, hydrogels, scaffolds, and 3D printing to improve their use in tissue healing and regeneration.

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Section: Introductionmentioning

confidence: 99%

Application of seaweed polysaccharide in bone tissue regeneration

Jin,

Yu,

et al. 2023

Front. Mar. Sci.

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Tibial bone strength is negatively affected by volumetric muscle loss injury to the adjacent muscle in male mice

Schifino

Cooley

Zhong

et al. 2023

Journal Orthopaedic Research

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This study's objective was to investigate how contractile strength loss associated with a volumetric muscle loss (VML) injury affects the adjacent tibial bone structural and functional properties in male C57BL/6J mice. Mice were randomized into one of two experimental groups: VML‐injured mice that were injured at age 12 weeks and aged to 20 weeks (8 weeks postinjury, VML) and 20‐week‐old age‐matched uninjured mice (Uninjured‐20). Tibial bone strength, mid‐diaphysis cortical geometry, intrinsic material properties, and metaphyseal trabecular bone structure were assessed by three‐point bending and microcomputed tomography (µCT). The plantar flexor muscle group (gastrocnemius, soleus, plantaris) was analyzed for its functional capacities, that is, peak‐isometric torque and peak‐isokinetic power. VML‐injured limbs had 25% less peak‐isometric torque and 31% less peak‐isokinetic power compared to those of Uninjured‐20 mice (p < 0.001). Ultimate load, but not stiffness, was significantly less (10%) in tibias of VML‐injured limbs compared to those from Uninjured‐20 (p = 0.014). µCT analyses showed cortical bone thickness was 6% less in tibias of VML‐injured limbs compared to Uninjured‐20 (p = 0.001). Importantly, tibial bone cross‐section moment of inertia, the primary determinant of bone ultimate load, was 16% smaller in bones of VML‐injured limbs compared to bones from Uninjured‐20 (p = 0.046). Metaphyseal trabecular bone structure was also altered up to 23% in tibias of VML‐injured limbs (p < 0.010). These changes in tibial bone structure and function after a VML injury occur during a natural maturation phase between the age of 12 and 20 weeks, as evidenced by Uninjured‐20 mice having greater tibial bone size and strength compared to uninjured‐aged 12‐week mice.

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