Minced Nerve Tissue in Vein Grafts Used as Conduits in Rat Tibial Nerves

Abstract

PLASTIC SURGERY 2014, Abstract Supplement 164 Figure 1.CONCLUSIONS: Women with larger BMI experience significantly higher rates of mastectomy alone without reconstruction despite having higher satisfaction with reconstruction and similar satisfaction with breast conservation surgery. This supports the notion that all patients being considered for mastectomy should be referred to a plastic surgeon for evaluation and plastic surgeons should highly consider use of abdominal fl ap reconstruction in this population, despite increased risk of complications. BACKGROUND: ADMs in immediate breast reconstruction with breast implants has been well documented and accepted for use. 1 The purpose of this study is to compare the use of porcine ADM with human ADM, made by the same company, in immediate breast reconstruction using breast implants and tissue expanders. Glassberg 2 and Salzberg 3 have reported results that are comparable for use of both products. Glassberg has shown a lower seroma rate with porcine ADM.

Assessment of Human Epineural Conduit of Different Size Diameters on Efficacy of Nerve Regeneration and Functional Outcomes

“…Although some studies have shown that the application of an EC has a positive effect on nerve regeneration as well as prevention of neuroma formation and muscle denervation atrophy, to the best of our knowledge, this is the first study reporting the use of the human epineurium as a biomaterial for the creation of the EC and application of the EC in the regeneration of nerve gaps. 15 28…”

Wound Repair and Regeneration

“…A meta-analysis of published papers determined that for nerve gaps up to 4 cm in length, vein conduits did not induce any significant improvement in sensory recovery outcome compared to conduits of other materials [170]. However, the axon regeneration-promoting efficacy of vein conduits is enhanced when they are filled with PRP [171][172][173], muscle [174], pre-degenerated muscle [175,176], muscle seeded with neural-transdifferentiated human mesenchymal stem cells [177], and minced peripheral nerves [178]. One study in sheep showed that using the median epineural sheath as a conduit can restore median nerve function across 6-cm-long nerve gaps [179].…”

Use of sliced or minced peripheral nerve segments for nerve regeneration through a biodegradable nerve conduit: A preliminary study in the rat

“…In 1986, Smahel and Jentsch used a rat femoral nerve defect to show that nerve regeneration through an autogenous venous conduit was achieved by embedding nerve segments within the venous conduit (Smahel & Jentsch, 1986). Using a similar experimental model, Sahin and colleagues demonstrated that nerve regeneration can be induced by incorporating manually shredded nerve tissues within the venous conduit (Sahin et al, 2014). In 2008, Hung and Dellon applied this approach in a clinical setting, harvesting a 3‐mm nerve segment from the proximal nerve stump of a 5‐cm median nerve defect and placing it within the biodegradable nerve conduit to reconstruct the median nerve, with improved sensory and motor function noted postoperatively (Hung & Dellon, 2008).…”