MIND diet associated with reduced incidence of Alzheimer's disease

Morris, Martha Clare; Tangney, Christy; Wang, Yamin; Sacks, Frank M.; Bennett, David; Aggarwal, Neelum T.

doi:10.1016/j.jalz.2014.11.009

Cited by 815 publications

(740 citation statements)

References 33 publications

Supporting

Mentioning

701

Contrasting

Unclassified

Order By: Relevance

“…The “MIND-diet,” which incorporates elements of both the Mediterranean diet and the “DASH diet,” has been linked with a lower risk of cognitive impairment 91 and the development of AD. 92 It is recognized that association in epidemiological studies does not prove causality. The FINGER and PREDIMED-NAVARRA studies were controlled interventional studies, helping to confirm causality.…”

Section: Potential Benefits Of Early Diagnosis Of Cognitive Impairmentmentioning

confidence: 99%

Brain Health: The Importance of Recognizing Cognitive Impairment: An IAGG Consensus Conference

Morley

Morris²,

Berg‐Weger

et al. 2015

Journal of the American Medical Directors Association

247

163

View full text Add to dashboard Cite

Cognitive impairment creates significant challenges for patients, their families and friends, and clinicians who provide their health care. Early recognition allows for diagnosis and appropriate treatment, education, psychosocial support, and engagement in shared decision-making regarding life planning, health care, involvement in research, and financial matters. An IAGG-GARN consensus panel examined the importance of early recognition of impaired cognitive health. Their major conclusion was that case-finding by physicians and health professionals is an important step toward enhancing brain health for aging populations throughout the world. This conclusion is in keeping with the position of the United States’ Centers for Medicare and Medicaid Services that reimburses for detection of cognitive impairment as part the of Medicare Annual Wellness Visit and with the international call for early detection of cognitive impairment as a patient’s right. The panel agreed on the following specific findings: (1) validated screening tests are available that take 3 to 7 minutes to administer; (2) a combination of patient- and informant-based screens is the most appropriate approach for identifying early cognitive impairment; (3) early cognitive impairment may have treatable components; and (4) emerging data support a combination of medical and lifestyle interventions as a potential way to delay or reduce cognitive decline.

show abstract

Section: Potential Benefits Of Early Diagnosis Of Cognitive Impairmentmentioning

confidence: 99%

Brain Health: The Importance of Recognizing Cognitive Impairment: An IAGG Consensus Conference

Morley

Morris²,

Berg‐Weger

et al. 2015

Journal of the American Medical Directors Association

247

163

View full text Add to dashboard Cite

show abstract

“…Certain diets show promising, preventive effects on brain aging and cognitive impairment in observational studies and in clinical trials [1–3]. Higher adherence to the Mediterranean diet (MeDi) is associated with a lower risk for AD [4–8]. Prospectively, we showed that a high percentage of daily calories derived from protein and fat were associated with a reduced risk of incident MCI, whereas a high percentage from carbohydrates was associated with an increased risk of incident MCI [9].…”

Section: Introductionmentioning

confidence: 99%

Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness

Staubo

Aakre

Vemuri

et al. 2016

Alzheimer's & Dementia

119

View full text Add to dashboard Cite

INTRODUCTION The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it’s unclear whether it’s associated with better brain imaging biomarkers. METHODS Among 672 cognitively normal participants (mean age: 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the 4 lobes separately and averaged (average lobar). RESULTS Higher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness. DISCUSSION In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross-sectional findings require validation in prospective studies.

show abstract

“…The Mediterranean diet [113], exercise [114] and caloric restriction [115,116] have been shown to modulate AD risk factors including the mitochondrial healthy homeostasis. In combination with these, several preventive approaches have been studied in AD patients, for example the antioxidant N-acetyl cysteine (NAC) [117], α-lipoic acid (LA) [118] and curcumin [119] have been tested.…”

Section: Therapeutic Approaches Targeted To Modulation Of Mitochondrimentioning

confidence: 99%

Mitochondrial Function in Alzheimer’s Disease: Focus on Astrocytes

Lampinen¹,

Belaya²,

Boccuni³

et al. 2018

Astrocyte - Physiology and Pathology

View full text Add to dashboard Cite

The brain is one of the most energy-requiring organs in the human body. Mitochondria not only generate this energy, but are centrally involved critical cellular functions including maintenance of calcium homeostasis, synthesis of biomolecules, and cell signaling. Even though neurons and astrocytes preferentially use different energy substrates and metabolic pathways, these two cell types are intricately linked in their energy metabolism. Recently it has become clear that astrocytes have a key role in the regulation and support of the neuronal mitochondrial quality control, yet several questions remain unanswered to fully understand the mechanisms of mitochondrial function, transport, turnover and degradation in astrocytes. Alzheimer's disease is the most common neurodegenerative disorder, the exact mechanisms of which remain incompletely understood. The fact that astrocytic mitochondrial dysfunction is an early event in the pathogenesis of Alzheimer's disease suggests that more research on mitochondrial function and impairment is required in the hopes of disease alleviation in the future.

show abstract

MIND diet associated with reduced incidence of Alzheimer's disease

Cited by 815 publications

References 33 publications

Brain Health: The Importance of Recognizing Cognitive Impairment: An IAGG Consensus Conference

Brain Health: The Importance of Recognizing Cognitive Impairment: An IAGG Consensus Conference

Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness

Mitochondrial Function in Alzheimer’s Disease: Focus on Astrocytes

Contact Info

Product

Resources

About