Mind over hormones; Sex differences in associations of well-being with IGF-I, IGFBP-3 and physical activity in the KORA-Age study

Emeny, Rebecca T.; Bidlingmaier, Martin; Lacruz, María Elena; Linkohr, Birgit; Peters, Annette; Reincke, Martín; Ladwig, Karl‐Heinz

doi:10.1016/j.exger.2014.08.001

Cited by 17 publications

(23 citation statements)

References 52 publications

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“…Eleven articles, published from 1988 to 2015 were included (Deuschle et al, 1997; Emeny et al, 2014; Franz et al, 1999; Kopczak et al, 2015; Lesch, Rupprecht, Muller, Pfuller, & Beckmann, 1988; F. Lin, Suhr, Diebold, & Heffner, 2014; Michelson et al, 2000; Rueda Alfaro et al, 2008; Sievers et al, 2014; van Varsseveld et al, 2015; Weber-Hamann et al, 2009).…”

Section: Resultsmentioning

confidence: 99%

“…Lin, Suhr, Diebold, & Heffner, 2014; Michelson et al, 2000; Rueda Alfaro et al, 2008; Sievers et al, 2014; van Varsseveld et al, 2015; Weber-Hamann et al, 2009). Six studies were conducted in Germany (Deuschle et al, 1997; Emeny et al, 2014; Kopczak et al, 2015; Lesch et al, 1988; Sievers et al, 2014; Weber-Hamann et al, 2009), and three in the US (Franz et al, 1999; F. Lin et al, 2014; Michelson et al, 2000).…”

Section: Resultsmentioning

confidence: 99%

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Role of trophic factors GDNF, IGF-1 and VEGF in major depressive disorder: A comprehensive review of human studies

Sharma

Silva

Soares

et al. 2016

Journal of Affective Disorders

120

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Rationale The neurotrophin hypothesis of major depressive disorder (MDD) postulates that this illness results from aberrant neurogenesis in brain regions that regulates emotion and memory. Notwithstanding this theory has primarily implicated BDNF in the neurobiology of MDD. Recent evidence suggests that other trophic factors namely GDNF, VEGF and IGF-1 may also be involved. Purpose The present review aimed to critically summarize evidence regarding changes in GDNF, IGF-1 and VEGF in individuals with MDD compared to healthy controls. In addition, we also evaluated the role of these mediators as potential treatment response biomarkers for MDD. Methods A comprehensive review of original studies studies measuring peripheral, central or mRNA levels of GDNF, IGF-1 or VEGF in patients with MDD was conducted. The PubMed/MEDLINE database was searched for peer-reviewed studies published in English through June 2nd, 2015. Results Most studies reported a reduction in peripheral GDNF and its mRNA levels in MDD patients versus controls. In contrast, IGF-1 levels in MDD patients compared to controls were discrepant across studies. Finally, most studies reported high peripheral VEGF levels and mRNA expression in MDD patients compared to healthy controls. Conclusions GDNF, IGF-1 and VEGF levels and their mRNA expression appear to be differentially altered in MDD patients compared to healthy individuals, indicating that these molecules might play an important role in the pathophysiology of depression and antidepressant action of therapeutic interventions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Role of trophic factors GDNF, IGF-1 and VEGF in major depressive disorder: A comprehensive review of human studies

Sharma

Silva

Soares

et al. 2016

Journal of Affective Disorders

120

View full text Add to dashboard Cite

show abstract

“…These differences might be due to patients' clinical characteristics such as age at onset (since we found an inverse correlation of IGF-1 with this parameter) or illness severity: in this regard, the depressive symptomatology in our sample (mean baseline HAM-D score: 19.7 ± 2.6) is milder than that of other studies [7,52] due to the recruitment of drug-free patients, a choice that excluded subjects with a more severe disorder. However, other studies [53,54,55] reported contrasting results and often observed a gender effect in the correlation between IGF-1 levels and depression incidence. Another possible reason explaining the difference in our results compared to other studies and the discrepancy between our findings in OCD and MDD patients might be previous drug exposure: MDD patients in our sample had stopped all medications at least 3 months before enrolment, while OCD patients were drug naïve.…”

Section: Discussionmentioning

confidence: 97%

Serum Levels of Insulin-Like Growth Factor-1 and Obsessive-Compulsive Disorder: A Case-Control Study

et al. 2016

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Background/Aims: Recent findings suggest an involvement of insulin-like growth factor-1 (IGF-1) in the pathogenesis of many psychiatric disorders; however, there is a lack of data regarding IGF-1 in patients with obsessive-compulsive disorder (OCD). The aims of the present study were (1) to analyze putative alterations of IGF-1 serum content in patients with OCD compared to patients with major depressive disorder (MDD) and healthy controls, and (2) to analyze putative changes of IGF-1 levels during drug treatment in subjects with OCD compared to patients with MDD. Methods: We recruited 40 OCD patients, 37 MDD patients, and 43 healthy controls. All participants were adults. Serum IGF-1 levels were measured by the ELISA method on venous blood samples collected at baseline and after 10 ± 1 weeks of drug treatment. Results: IGF-1 levels were increased in OCD patients compared to controls (149.9 ± 60.2 vs. 121.2 ± 51.6 ng/ml; p = 0.040). No correlations were observed between baseline IGF-1 levels, clinical features, and response to treatment at follow-up in OCD or MDD patients. No changes in serum IGF-1 were observed after drug treatment. Conclusion: Our results show for the first time that serum IGF-1 levels are altered in patients with OCD. Further research on the role of IGF-1 in OCD is warranted.

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“…Major depressive disorder (MDD) is recognised as an inflammatory disorder characterised by reactive oxygen species and immune dysregulation that can overwhelm usual defensive physiological processes. Milk consumption increases circulating insulin-like growth factor-1 and there is a positive association between this factor and depression [4]. Moreover, milk proteins such as lactoferrin impact neuronal differentiation [5], while milk whey protein alters brain mitochondrial activity and oxidative stress markers [6].…”

Section: Tablementioning

confidence: 99%

Milk Consumption and the Risk for Incident Major Depressive Disorder

Pasco¹,

Williams²,

Brennan-Olsen³

et al. 2015

Psychother Psychosom

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Mind over hormones; Sex differences in associations of well-being with IGF-I, IGFBP-3 and physical activity in the KORA-Age study

Cited by 17 publications

References 52 publications

Role of trophic factors GDNF, IGF-1 and VEGF in major depressive disorder: A comprehensive review of human studies

Role of trophic factors GDNF, IGF-1 and VEGF in major depressive disorder: A comprehensive review of human studies

Serum Levels of Insulin-Like Growth Factor-1 and Obsessive-Compulsive Disorder: A Case-Control Study

Milk Consumption and the Risk for Incident Major Depressive Disorder

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