Mindfulness-based cancer recovery in survivors recovering from chemotherapy and radiation

Blaes, Anne; Fenner, Danyelle; Bachanová, Veronika; Torkelson, Carolyn J.; Geller, Melissa A.; Haddad, Tufia C.; Shanley, Ryan; Kreitzer, MaryJo

doi:10.12788/jcso.0244

Cited by 18 publications

(37 citation statements)

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“…Our electronic search strategy identified 5686 citations, of which 27 trials met the eligibility criteria ( Figure 1 ). 16 , 18 , 19 , 20 , 21 , 22 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 We included 1 additional trial identified through hand searching. One trial by Compen et al 21 randomized patients to in-person MBCT, internet-based MBCT, and usual care cohorts and thus represented 2 separate analyses, for an overall total of 29 mindfulness-based comparisons (3053 participants).…”

Section: Resultsmentioning

confidence: 99%

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Association of Mindfulness-Based Interventions With Anxiety Severity in Adults With Cancer

et al. 2020

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IMPORTANCE Mindfulness-based interventions (MBIs), grounded in mindfulness, focus on purposely paying attention to experiences occurring at the present moment without judgment. MBIs are increasingly used by patients with cancer for the reduction of anxiety, but it remains unclear if MBIs reduce anxiety in patients with cancer. OBJECTIVE To evaluate the association of MBIs with reductions in the severity of anxiety in patients with cancer. DATA SOURCES Systematic searches of MEDLINE, Embase, Cochrane Central Register of Controlled Trials, CINAHL, PsycINFO, and SCOPUS were conducted from database inception to May 2019 to identify relevant citations. STUDY SELECTION Randomized clinical trials (RCTs) that compared MBI with usual care, waitlist controls, or no intervention for the management of anxiety in cancer patients were included. Two reviewers conducted a blinded screening. Of 101 initially identified studies, 28 met the inclusion criteria. DATA EXTRACTION AND SYNTHESIS Two reviewers independently extracted the data. The Cochrane Collaboration risk-of-bias tool was used to assess the quality of RCTs, and the Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guideline was followed. Summary effect measures were reported as standardized mean differences (SMDs) and calculated using a random-effects model. MAIN OUTCOMES AND MEASURES Our primary outcome was the measure of severity of shortterm anxiety (up to 1-month postintervention); secondary outcomes were the severity of mediumterm (1 to Յ6 months postintervention) and long-term (>6 to 12 months postintervention) anxiety, depression, and health-related quality of life of patients and caregivers. RESULTS This meta-analysis included 28 RCTs enrolling 3053 adults with cancer. None of the trials were conducted in children. Mindfulness was associated with significant reductions in the severity of short-term anxiety (23 trials; 2339 participants; SMD, −0.51; 95% CI, −0.70 to −0.33; I 2 = 76%). The association of mindfulness with short-term anxiety did not vary by evaluated patient, intervention, or study characteristics. Mindfulness was also associated with the reduction of medium-term anxiety (9 trials; 965 participants; SMD, −0.43; 95% CI, −0.68 to −0.18; I 2 = 66%). No reduction in long-term anxiety was observed (2 trials; 403 participants; SMD, −0.02; 95% CI, −0.38 to 0.34; I 2 = 68%). MBIs were associated with a reduction in the severity of depression in the short term (19 trials; 1874

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Section: Resultsmentioning

confidence: 99%

“…Even in trials including more than 1 type of cancer (11 trials), breast cancer was the most common diagnosis in all but 1. 21 , 40 , 44 , 49 , 51 , 53 …”

Section: Resultsmentioning

confidence: 99%

Association of Mindfulness-Based Interventions With Anxiety Severity in Adults With Cancer

et al. 2020

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“…)Control group,• Baseline ( n = 176); mean (95% CI) = 40.8 (38.9–42.8)• Month 6 ( n = 156); mean (95% CI) = 40.7 (38.7–42.8)Intervention group• Baseline ( n = 176); mean (95% CI) = 39.0 (37.0–40.9)• Month 6 ( n = 147); mean (95% CI) = 36.4 (34.2–38.5)Bennett 2007 [15]Schwartz Cancer Fatigue Scale5628286 monthsOn average, the level of fatigue status for all participants was 15.20 at baseline and declined 4.22 points (27%) across the study.Group × Time interaction for fatigue was significant [Λ =0.78, F (2,37) = 5.24, p = 0.010]. However, inspection of the graph showed this was an artifact of 3-month measures, whereas values at baseline and at 6 months showed no significant differences between groups, leading to the conclusion that the significant effect of the interaction was the result of measurement error.Blaes 2016 [16]Functional Assessment in cancer Therapy-Fatigue ( FACT-F)4228144 monthsThere was an improvement in fatigue in both groups with time. Mean improvement from baseline to 4 months was 6.8 for the MBCR group and 1.3 for controls ( p = 0.19).There was no statistically significant difference in improvement in fatigue for two groups.Bower 2015 [17]Fatigue Symptom Inventory7139323 monthsMindfulness led to significant improvements in fatigue ( p = 0.007), from pre- to post-intervention.No group differences in change from baseline to 3-month follow-up p = 0.57Bruggeman-Everts 2017 [18]Checklist Individual Strength - Fatigue Severity [CIS-FS] subscale167551129 weeksAAF = eMBCT = psycho-educationχ2(4)=27.63, p < .001AAF = psycho-educationχ2(2)=28.28, p < .001eMBCT = psycho-educationχ2(2)=10.89, p = .004AAF = eMBCTχ2(2)=2.19, p = .34Multiple group latent growth curve analysis, corrected for individual time between assessments, showed that fatigue severity decreased significantly more in the AAF and eMBCT groups compared to the psychoeducational group.Carlson 2013 (2016) [19, 45]POMS2711131586 and 12 months later.Group-by-time effect at intervention (6months): p = 0.00195% CI − 0.45 [− 0.70; − 0.20]Group-by-time effect at follow-up (12 months) p = 0.76Dirksen 2008 [20]Profile of Mood States Fatigue/Inertia Subscale (POMSF/I)7234382 weeksStatistically significant pre- to post-treatment change ( p < 0.05).From pre- to post-treatment, the CBT-I group improved on fatigue.…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies [16, 17, 19, 30, 31, 35, 49] reported on mindfulness-based interventions. Two of the studies were specifically aimed at CrF [30, 49], and three were focused on cancer [16, 19, 35].…”

Section: Resultsmentioning

confidence: 99%

“…A variety of different measures were used to assess fatigue. The Brief Fatigue Inventory (BFI) was used in five studies [14, 17, 26, 29, 43] and the Functional Assessment in Cancer Therapy-Fatigue (FACIT-F) was used in five studies [16, 24, 27, 29, 34]. Five studies used the Fatigue Symptom Inventory (FSI) [17, 23, 35, 37, 49] and the Multidimensional Fatigue Inventory (MFI) was used in four studies [25, 39–41].…”

Section: Resultsmentioning

confidence: 99%

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The effectiveness of psychological interventions for fatigue in cancer survivors: systematic review of randomised controlled trials

et al. 2019

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BackgroundFatigue is a common symptom in cancer patients that can persist beyond the curative treatment phase. This systematic review evaluated the effectiveness of psychological interventions for cancer-related fatigue in post-treatment cancer survivors.MethodsWe searched relevant online databases and sources of grey literature. Randomised controlled trials (RCTs) evaluating psychological interventions in adult cancer patients after the completion of treatment, with fatigue as an outcome measure, were included. Two review authors extracted data independently from the selected studies and assessed the methodological quality using the Cochrane Collaboration Risk of Bias Tool.ResultsThirty-three psychological interventions were identified. The sample size of the included studies varied between 28 and 409, with 4525 participants overall. Twenty-three of the included studies reported a significant effect of the interventions on reducing fatigue in cancer survivors. Most interventions focused on psychoeducation, mindfulness, cognitive or behaviour therapy-oriented strategies. However, studies differed widely in terms of measurement tools used to assess fatigue, mode, duration and frequency of the intervention delivery.ConclusionsThis review showed some tentative support for psychological interventions for fatigue after cancer treatment. However, as the RCTs were heterogeneous in nature and the number of high-quality studies was limited, definitive conclusions are not yet possible. With the growing need for stage-specific research in cancer, this review sought to inform current practice and to summarise the existing evidence base of randomised controlled trials in the area.Systematic review registrationPROSPERO registration number: CRD42014015219.

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Prehabilitative/rehabilitative exercise, nutrition, and psychological support for bladder cancer: A scoping review of randomized clinical trials

Briggs,

Parke,

Beck

et al. 2024

Cancer

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The study of prehabilitation and rehabilitation ([p]rehabilitation) to alleviate the sequelae of bladder cancer and its treatment has generated numerous opportunities to improve the quality of life of bladder cancer survivors. The authors conducted a scoping review of randomized clinical trials (RCTs) to identify knowledge gaps in and research directions for (p)rehabilitative support for those affected by bladder cancer. The authors systematically searched six databases and synthesized key findings from RCTs conducted from January 1, 2004, through March 15, 2022, that enrolled participants with bladder cancer, survivors, or caregivers in outpatient (p)rehabilitative programs (e.g., exercise, nutrition, or psychological support). Outcomes were characterized according to eight prespecified, clinically relevant categories. The search retrieved 10,968 records, 27 of which met the inclusion criteria, and 24 described unique RCTs with 2471 enrolled participants. Of 24 interventions, 17 (71%) yielded statistically significant results for the outcome of interest. Only one RCT included a cost‐effectiveness analysis, and only two characterized the efficacy of interventions for caregivers. Of 11 RCTs involving psychological support, eight yielded statistically significant results, as did nine of 11 RCTs with physical exercise interventions, three of four RCTs with educational interventions, three of four RCTs with nutritional support interventions, one of two RCTs with pharmacologic medications, and zero of one RCT with physical therapy. The most promising interventions for inclusion in multimodal, personalized (p)rehabilitation programs included exercise, stress management training, cognitive training, smoking and alcohol cessation counseling, immunonutrition, stoma education, and penile rehabilitation. Further studies of the cost effectiveness and efficacy for caregivers of such interventions are needed.Plain Language Summary In a scoping review of all randomized clinical trials involving prehabilitative or rehabilitative diet, exercise, and psychological support interventions for patients with bladder cancer, survivors, and their caregivers, 17 of 24 (71%) interventions yielded statistically significant improvements in the outcome of interest. Clinicians should consider implementing such interventions for those affected by bladder cancer.

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Mindfulness-based cancer recovery in survivors recovering from chemotherapy and radiation

Cited by 18 publications

References 0 publications

Association of Mindfulness-Based Interventions With Anxiety Severity in Adults With Cancer

Association of Mindfulness-Based Interventions With Anxiety Severity in Adults With Cancer

The effectiveness of psychological interventions for fatigue in cancer survivors: systematic review of randomised controlled trials

Prehabilitative/rehabilitative exercise, nutrition, and psychological support for bladder cancer: A scoping review of randomized clinical trials

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