Post-Traumatic Stress Disorder (PTSD) poses significant challenges, demanding a multifaceted approach to treatment. This chapter aims to explore non-traditional interventions, psychoactive substances, and medical procedures in managing PTSD. From yoga, meditation, and exercise to the role of outdoor environments, psychoactive substances, and innovative medical procedures like stellate ganglion blocking and trans-cranial stimulation. This chapter delves into the efficacy, mechanisms, and potential integration of these interventions in PTSD treatment.