The disturbance depth of traffic load has a direct impact on the stability of a room-and-pillar mining goaf. To quantitatively calculate the relationship between the traffic load disturbance depth and influencing factors, 49 groups of horizontal combinations of different influencing parameters are designed in this study, based on the orthogonal experimental design method. Midas GTS is used to simulate and obtain the corresponding traffic load disturbance depth data. A multivariate linear regression analysis of the traffic load disturbance depth is conducted, and a regression formula for calculating the traffic load disturbance depth is established. According to the traffic load disturbance depth, goaf depth, and the stability of the roof, coal pillar, and base plate under traffic load conditions, a judgment flow of the room-and-pillar mining goaf treatment method under traffic load conditions is established, and it is applied to the reconstruction and expansion project of the Jixi section of the Dan-A national highway. The results show that a geogrid can be used for treatment purposes when the traffic load disturbance depth is 1.5 times lower than the depth of the room-and-pillar mining goaf, or when the traffic load disturbance depth is 1.5 times greater than the depth of the room-and-pillar mining goaf but the roof, coal pillar, and base plate are stable. Additionally, grouting is needed for treatment in other cases. The results of this study can provide a scientific basis for the selection of treatment methods for room-and-pillar mining goafs underlying highways in the future. The results are of great significance in the field of engineering for the safety measures concerning highway room-and-pillar mining goafs.