This study looked at how weaned pigs' blood biochemical indicators were affected when doum palm meal (DPM) was used in part lieu of maize. After being weaned at 28 days of age and weighing 7.40 ± 0.09 kg at birth, fifty Landrace × Duroc crossbred pigs were divided into divisions based on their body weights and given five distinct experimental diets. Over the course of a ninety-day fully randomized design experiment. Diets 1, 2, 3, 4, and 5 were fed 0 %, 5 %, 10 %, 15 %, and 20 % DPM in place of maize. The NRC (2012) states that the experimental diet satisfied the pigs' needs, and clean water was provided daily and at will. DPM had the following elements: manganese (0.91 mg/100g), zinc (0.72 mg/100g), copper (0.35 mg/100g), iron (5.60 mg/100g), calcium (371.20 mg/100g), potassium (966.31 mg/100g), phosphorus (206.19 mg/100g), magnesium (150.67 mg/100g), and zinc. The values of total serum protein, albumin, globulin, creatinine, alanine phosphatase, aspartate transaminase, sodium, potassium, calcium, phosphorus, and bicarbonate were not affected (P˃0.05) by the treatments, with the exception of the glucose level, which was higher (P˂0.05) in D1 than in the other treatments. It has been shown that DPM can partially replace up to 20% of maize without causing metabolic problems or adversely influencing the health of the animals.