Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases

Ma, Chenhui; Li, Han; Zhu, Zheying; Pang, Cheng Heng; Pan, Guoyu

doi:10.1016/j.bcp.2022.115242

Cited by 36 publications

(20 citation statements)

References 188 publications

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“… 43 A plethora of research work has explored the role and mechanism of iron metabolism, iron deposition, and ferroptosis in MAFLD, and researchers have reviewed and discussed this in considerable detail. 44–46 Biopsies confirm poorer long-term outcomes in patients with NAFLD and iron overload, 47 which may be due to elevated insulin resistance, excess hepatic lipid peroxidation, and iron overload contributing to the progression of liver fibrosis. GPX4-reduced ferroptosis is a crucial trigger for MAFLD progression to NASH.…”

Section: Ferroptosis In Metabolism-related Fatty Liver Diseasementioning

confidence: 99%

The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge

Zhu¹,

Luo²,

Zhu³

et al. 2023

JIR

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Ferroptosis is a recently identified iron-dependent form of intracellular lipid peroxide accumulation-mediated cell death. Different from other types of cell death mechanisms, it exhibits distinct biological and morphological features characterized by the loss of lipid peroxidase repair activity caused by glutathione peroxidase 4, the presence of redox-active iron, and the oxidation of phospholipids-containing polyunsaturated fatty acids. In recent years, studies have shown that ferroptosis plays a key role in various liver diseases such as alcoholic liver injury, non-alcoholic steatohepatitis, liver cirrhosis, and liver cancer. However, the mechanism of ferroptosis and its regulation on chronic liver disease are controversial among different types of cells in the liver. Herein, we summarize the current studies on mechanism of ferroptosis in chronic liver disease, aiming to outline the blueprint of ferroptosis as an effective option for chronic liver disease therapy.

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Section: Ferroptosis In Metabolism-related Fatty Liver Diseasementioning

confidence: 99%

The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge

Zhu¹,

Luo²,

Zhu³

et al. 2023

JIR

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show abstract

“…Because of the lack of efficient diagnostic methods and therapeutic targets, early detection and treatment of NAFLD still face many challenges. The underlying mechanism for the pathogenesis and progression of NAFLD is complex, and disturbance in trace element and mineral metabolism and interactions have been identified as one of the key risk factors of this disease ( 169 , 170 ). As NAFLD is closely associated with the components of MetS, obesity, and T2DM, a change in nomenclature from NAFLD to metabolic-associated fatty liver disease (MAFLD) has been recently proposed, which may better reflect the underlying pathophysiology of this disease ( 171 ).…”

Section: Recent Progress In Ionomics Of Metabolic Diseasesmentioning

confidence: 99%

Recent advances in the application of ionomics in metabolic diseases

et al. 2023

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Trace elements and minerals play a significant role in human health and diseases. In recent years, ionomics has been rapidly and widely applied to explore the distribution, regulation, and crosstalk of different elements in various physiological and pathological processes. On the basis of multi-elemental analytical techniques and bioinformatics methods, it is possible to elucidate the relationship between the metabolism and homeostasis of diverse elements and common diseases. The current review aims to provide an overview of recent advances in the application of ionomics in metabolic disease research. We mainly focuses on the studies about ionomic or multi-elemental profiling of different biological samples for several major types of metabolic diseases, such as diabetes mellitus, obesity, and metabolic syndrome, which reveal distinct and dynamic patterns of ion contents and their potential benefits in the detection and prognosis of these illnesses. Accumulation of copper, selenium, and environmental toxic metals as well as deficiency of zinc and magnesium appear to be the most significant risk factors for the majority of metabolic diseases, suggesting that imbalance of these elements may be involved in the pathogenesis of these diseases. Moreover, each type of metabolic diseases has shown a relatively unique distribution of ions in biofluids and hair/nails from patients, which might serve as potential indicators for the respective disease. Overall, ionomics not only improves our understanding of the association between elemental dyshomeostasis and the development of metabolic disease but also assists in the identification of new potential diagnostic and prognostic markers in translational medicine.

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“…Copper is an indispensable trace element that serves as a structural and enzymatic cofactor for various antioxidant proteins, including cytochrome c oxidase (COX), superoxide dismutase (SOD), and ceruloplasmin ( 7 ). Excessive or deficient copper can lead to mitochondrial dysfunction or dyslipidemia ( 8 ). A typical example is Wilson's disease, an overloaded hepatic copper accumulation and insufficient ceruloplasmin with liver steatosis, inflammation, and cuprotosis ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…Whereas, the relationship between serum/hepatic copper levels and NAFLD is still unclear. What's more, it is reported that lower hepatic copper is associated with NAFLD, but excessive copper also impairs hepatocytes ( 8 , 13 ). Lan, et al find that blood copper concentration is lower in NAFLD patients ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Comparison of copper concentration between non-alcoholic fatty liver disease patients and normal individuals: A meta-analysis

Chen

et al. 2023

Front. Public Health

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Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. Copper metabolism plays an important role in the pathogenesis of NAFLD. However, the relationship between serum/hepatic copper concentration and NAFLD is still debated. A literature search was performed using electronic databases to find publications up to September 2022, where the relationship between serum/hepatic copper or ceruloplasmin concentration and NAFLD was evaluated. Finally, 6 articles with 9 unique outcomes involving 2,607 NAFLD patients and 1,441 non-NAFLD normal individuals were included. The pooled results showed that hepatic copper concentration was significantly decreased in NAFLD patients (SMD = −0.98, 95% CI = [−1.21; −0.74], p < 0.0001), and the sensitivity analysis also confirmed this. Nevertheless, serum copper (SMD = −0.02, 95% CI = [−0.32; 0.28], p = 0.88) and ceruloplasmin (SMD = −0.03, 95% CI = [−0.69; 0.63], p = 0.93) were not associated with NAFLD. This meta-analysis revealed that low hepatic copper concentration was found in NAFLD patients and serum copper and ceruloplasmin were not associated with NAFLD. Larger cohort studies and related trials are needed to further validate the result of this meta-analysis in the future.

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Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases

Cited by 36 publications

References 188 publications

The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge

The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge

Recent advances in the application of ionomics in metabolic diseases

Comparison of copper concentration between non-alcoholic fatty liver disease patients and normal individuals: A meta-analysis

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