Mineral Metabolism on Rice Diets

Cullumbine, H.; Basnayake,; Lemottee, J; Tw, Wickramanayake

doi:10.1079/bjn19500025

Cited by 56 publications

(17 citation statements)

References 11 publications

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“…Nevertheless, for a long time IP 6 was considered as an antinutrient due to its capacity to form insoluble complexes with trace elements, such as zinc, iron and copper in vitro, and, as a consequence, perhaps to a decrease in the bioavailability of these elements in vivo. However, recent studies demonstrate that this "antinutrient" effect of IP 6 is only manifested when large quantities of IP 6 are consumed in combination with oligoelements-poor diet [2,10,14,23]; the daily consumption of 1-2 g IP 6 with balanced diets did not affect the mineral status in humans [2,23].…”

Section: Introductionmentioning

confidence: 99%

Absorption and excretion of orally administered inositol hexaphosphate (IP₆ or phytate) in humans

et al. 2001

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A study of the pharmacokinetic profile (oral absorption and renal excretion) of inositol hexaphosphate or phytate (IP(6)) is presented. Seven healthy volunteers were following a IP(6) poor diet (IP(6)PD) in a first period, and on IP(6) normal diet (IP(6)ND) in a second one. When following the IP(6)PD they become deficient in IP(6), the basal levels found in plasma (0.07+/- 0.01 mg/L) being clearly lower than those found when IP(6)ND was consumed (0.26+/- 0.03 mg/L). During the restriction period the maximum concentration in plasma were obtained 4 h after the ingestion of a single dose of IP(6), observing almost the same renal excretion profiles for the three different commercial sources and doses. After the IP(6) restriction period, volunteers were on IP(6)ND, reaching normal plasma and urinary IP(6) values in 16 days. Thus, the normal plasma and urinary concentrations, can be obtained either by consumption of a IP(6)ND taking a long time or in a short period by IP(6) supplements.

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Section: Introductionmentioning

confidence: 99%

Absorption and excretion of orally administered inositol hexaphosphate (IP₆ or phytate) in humans

et al. 2001

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“…In this aspect it must be considered that the unique negative effects associated with the phytate consumed must be related to oligoelement bioavailability. The present knowledge about this clearly demonstrated that low/moderate consumption of phytate, as part of a balanced diet, did not produce negative effects on oligoelement bioavailability [25,26]. Precisely, a recent study demonstrated that rats fed 1% phytate as sodium salt, considered to be a phytate-rich diet, did not manifest important alterations in mineral bioavailability, not even in the second animal generation [27,28].…”

Section: Discussionmentioning

confidence: 99%

Study of Potassium Phytate Effects on Decreasing Urinary Calcium in Rats

Gráses

Perelló²,

Simonet³

et al. 2004

Urol Int

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Background: Phytate as sodium salt has been used at high doses to treat stone-former patients with idiopathic hypercalciuria. The experimental and clinical hypocalciuric effects of dietary fiber have also been assigned to the presence of phytate as calcium-magnesium salt (phytin). As a consequence of the additional interest in phytate due to its capacity as crystallization inhibitor, now a study of the effects of potassium phytate on urinary calcium excretion is presented and compared with the effects caused by other phytate salts. Methods: To study the effect of calcium-magnesium phytate, 36 Wistar rats (6 groups) were fed with a purified diet in which phytate was practically absent (4068.02 Reference Diet). Three groups were fed with increasing calcium amounts and with the same amount of phytin, each one corresponding to one control group. To study the effects of magnesium-potassium, sodium and potassium phytate salts, 48 Wistar rats (8 groups) were fed with UAR-A04 diet (a standard diet which contains 0.8% of phytin). Two control groups fed with low and high calcium amounts and 6 treated groups were formed. The effect of the dose of potassium phytate on urinary calcium was carried out using 2 additional groups of 6 Wistar rats each one fed with UAR-A04 diet and increasing amounts of potassium phytate. Results: No significant changes in urinary calcium were observed when phytin (calcium-magnesium phytate) was supplied. The urinary calcium was clearly reduced by the three phytate salts assayed (magnesium-potassium, sodium, potassium), but the most significant decrease was noticed when the potassium phytate salt was administered. Phytate administration, independently of the salt or dose used, did not significantly affect the urinary oxalate. Conclusion: It can be clearly deduced that the effects of phytate on the urinary parameters, mainly calcium, fundamentally depend on the type of salt used. Thus, the most remarkable effects on urinary calcium reduction were caused by the potassium salt. Obviously, these findings must be confirmed in human studies.

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“…65,66 Thus, decreased bioavailability of minerals is likely to be a chronic problem only when the mineral intake is inadequate and absorption cannot be increased. 65,67,68 In the United States and other industrialized countries, vitamin/mineral intake generally is adequate and DF intake is moderately low.…”

Section: Safety Of High Dietary Fiber Intake In Childhoodmentioning

confidence: 99%

Dietary fiber in childhood

Williams

2006

The Journal of Pediatrics

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Mineral Metabolism on Rice Diets

Cited by 56 publications

References 11 publications

Absorption and excretion of orally administered inositol hexaphosphate (IP₆ or phytate) in humans

Absorption and excretion of orally administered inositol hexaphosphate (IP₆ or phytate) in humans

Study of Potassium Phytate Effects on Decreasing Urinary Calcium in Rats

Dietary fiber in childhood

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Mineral Metabolism on Rice Diets

Cited by 56 publications

References 11 publications

Absorption and excretion of orally administered inositol hexaphosphate (IP6 or phytate) in humans

Absorption and excretion of orally administered inositol hexaphosphate (IP6 or phytate) in humans

Study of Potassium Phytate Effects on Decreasing Urinary Calcium in Rats

Dietary fiber in childhood

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Product

Resources

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Absorption and excretion of orally administered inositol hexaphosphate (IP₆ or phytate) in humans

Absorption and excretion of orally administered inositol hexaphosphate (IP₆ or phytate) in humans