Mineral oil granuloma of the penis

Hohaus, K.; Bley, B; Köstler, E; Schönlebe, Jaqueline; Wollina, Uwe

doi:10.1046/j.1468-3083.2003.00896.x

Cited by 47 publications

(41 citation statements)

References 12 publications

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“…Similar lesions are observed in the rat as well as in human livers with cirrhosis [5,6,9,10]. Additionally, human "sclerosing lipogranulomas" occur in the subcutaneous fat tissues of the genital region, buttocks, and extremities and in the orbit [1,11,17,19]. Regarding canine PSS, however, a detailed histopathological characterization has not been made.…”

Section: Discussionmentioning

confidence: 94%

Histopathological Characteristics of Hepatic Lipogranulomas with Portosystemic Shunt in Dogs

Isobe

Matsunaga

Nakayama

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. In the canine liver with portosystemic shunts (PSS), focal lesions consisting of cells with cytoplasmic brown pigments and lipid vacuoles are often observed in the hepatic parenchyma. Termed lipogranulomas, their histopathological characteristics have been little studied. In the present study, we examined liver biopsy samples from 144 dogs (age: 3 months-16 years; 65 PSS and 79 non-PSS cases), and investigated the histopathological characteristics, incidence, and density of lipogranulomas. Lipogranulomas were detected histopathologically in 55.4% of PSS dogs. The lesions were then grouped into 3 types according to the amount of cytoplasmic lipid vacuoles and brown pigments. The pigments were positive for Berlin blue, PAS, and Sudan black B, but negative with the Hall method. The majority of the cells were immunohistochemically positive for macrophage scavenger receptor, class A (MSR-A), while no cells were positive for hepatocyte-antigen and albumin. The cytoplasmic pigments were recognized as electron-dense microgranular materials by electron microscopy. The incidence of lipogranulomas was significantly higher in the PSS group than non-PSS group when dogs less than 1 year old were excluded. The lipogranuloma density in the liver was significantly higher in the PSS group. It is concluded that lipogranulomas are frequently observed in liver biopsies of canine PSS especially in dogs more than 1 year old. The lesions consisted of Kupffer cells and/or macrophages, and the cytoplasmic brown pigments are ceroid and hemosiderin. The pathogenesis of lipogranuloma in PSS needs to be clarified.

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Section: Discussionmentioning

confidence: 94%

Histopathological Characteristics of Hepatic Lipogranulomas with Portosystemic Shunt in Dogs

Isobe

Matsunaga

Nakayama

et al. 2008

The Journal of Veterinary Medical Science

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“…While rare, lipogranuloma is most commonly documented in the urologic literature, as the most common site is the genitals of young adults secondary to the injection of foreign materials for penile augmentation, as described by Hohaus (2003). Few reports exist in the literature which describe lipogranuloma of the head and neck.…”

Section: Discussionmentioning

confidence: 99%

Lipogranuloma of the Head and Neck

Fundakowski¹,

Chapman²,

Sargi³

2012

IJCRM

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Objective: To report a rare case of lipogranuloma of the head & neck.Case Report: We present a 33-year old female patient with a 2-month history of left neck mass refractory to antibiotic therapy. Laboratory workup and fine needle aspiration biopsy was nondiagnostic. Excisional biopsy revealed histologic evidence of a granulomatous soft tissue reaction consistent with lipogranuloma. Lipogranuloma is a very rare finding in the head and neck which typically manifests clinically with painless palpable lymphadenopathy. Two mechanisms have been described for the etiology of lipogranulomas: (1) an exogenous foreign body reaction to either a lipid or oil-like substance, and the more rare (2) endogenous degeneration secondary to an allergic/inflammatory mechanism as a result of severe heat/cold and/or trauma. Given the patient's history of motor vehicle accident 3 months prior with concurrent neck strain injury, the etiology of lipogranuloma is this case is likely due to endogenous lipid degeneration. Conclusion:This case reports the rare clinical finding of a patient with lipogranuloma likely secondary to endogenous inflammatory lipid degeneration.

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“…Microscopic changes manifest macroscopically in the form of undesired reactions including inflammation, edema, scarring, necrosis, deformity, ulceration, and sterile abscesses [3,5]. There is granulomatous inflammation with multiple clear vacuoles, resulting in a "Swiss cheese" appearance [6].…”

Section: Discussionmentioning

confidence: 99%

Difficult evaluation of thyroid cancer due to cervical paraffin injection

et al. 2011

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Paraffinoma is a well known complication of previous paraffin injection into the subcutaneous layer that presents as various conditions including firm mass formation, edema, induration, ulceration, and skin necrosis. Paraffinoma can mimic neoplasm on physical examination and imaging studies and may complicate ultrasonographic diagnoses due to typical posterior shadowing and high echogenicity. When paraffinomas involve around the thyroid gland, the diagnosis of thyroid tumors is very difficult. We present a case of thyroid cancer, the evaluation of which was complicated by the presence of cervical paraffinoma.

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Mineral oil granuloma of the penis

Cited by 47 publications

References 12 publications

Histopathological Characteristics of Hepatic Lipogranulomas with Portosystemic Shunt in Dogs

Histopathological Characteristics of Hepatic Lipogranulomas with Portosystemic Shunt in Dogs

Lipogranuloma of the Head and Neck

Difficult evaluation of thyroid cancer due to cervical paraffin injection

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